CN1875944A - 一种聚乙二醇修饰的羟基喜树碱隐形脂质纳米球及其制备方法 - Google Patents
一种聚乙二醇修饰的羟基喜树碱隐形脂质纳米球及其制备方法 Download PDFInfo
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- CN1875944A CN1875944A CN 200610028370 CN200610028370A CN1875944A CN 1875944 A CN1875944 A CN 1875944A CN 200610028370 CN200610028370 CN 200610028370 CN 200610028370 A CN200610028370 A CN 200610028370A CN 1875944 A CN1875944 A CN 1875944A
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- hydroxycamtothecine
- stealthy liposome
- nanosphere
- liposome nanosphere
- vitamin
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Abstract
Description
时间/月 | 隐形脂质纳米球乳剂 | |||||||||||
4℃ | 25℃ | 4℃ | 25℃ | |||||||||
外观 | 粒径 | PI | 外观 | 粒径 | PI | 外观 | 粒径 | PI | 外观 | 粒径 | PI | |
0123 | 乳白色液体乳白色液体乳白色液体乳白色液体 | 130.9135.3136.7142.6 | 0.0630.0720.0830.079 | 乳白色液体乳白色液体乳白色液体乳白色液体 | 130.9147.8153.4201.2 | 0.0630.0920.0810.124 | 乳白色液体乳白色液体乳白色液体乳白色液体 | 189.6199.7203.6221.3 | 0.0480.0570.0530.060 | 乳白色液体乳白色液体乳白色液体药物析出 | 189.6258.9522.3582.1 | 0.0480.1020.3780.449 |
6 | 乳白色液体 | 140.5 | 0.074 | 乳白色液体 | 224.3 | 0.196 | 乳白色液体 | 225.7 | 0.119 | 药物析出 | 773.2 | 0.753 |
pH | 内酯型结构% | 开环结构% |
5.796.987.938.36 | 92.8175.0544.9024.10 | 7.1924.9555.1075.90 |
pH | 内酯型结构(%) | 开环结构(%) |
5678 | 98.8497.9193.7784.26 | 1.162.096.2315.74 |
Claims (15)
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CN2006100283701A CN1875944B (zh) | 2006-06-29 | 2006-06-29 | 一种聚乙二醇修饰的羟基喜树碱隐形脂质纳米球及其制备方法 |
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CN2006100283701A CN1875944B (zh) | 2006-06-29 | 2006-06-29 | 一种聚乙二醇修饰的羟基喜树碱隐形脂质纳米球及其制备方法 |
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CN1875944A true CN1875944A (zh) | 2006-12-13 |
CN1875944B CN1875944B (zh) | 2011-01-05 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101229131B (zh) * | 2008-01-30 | 2010-06-02 | 中国科学院上海药物研究所 | 具有降低喜树碱类药物胃肠毒性的新型纳米微粒制剂 |
CN103772696A (zh) * | 2014-01-06 | 2014-05-07 | 济南大学 | 一种羟基喜树碱的聚甘油脂肪酸酯衍生物 |
CN108567742A (zh) * | 2017-03-14 | 2018-09-25 | 中国科学院上海药物研究所 | Sn38脂质组合物、其制备方法和用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1732608A2 (en) * | 2004-01-22 | 2006-12-20 | Immunomedics, Inc. | Folate conjugates and complexes |
CN100356919C (zh) * | 2004-05-31 | 2007-12-26 | 上海医药工业研究院 | 羟基喜树碱脂质体及其制备方法 |
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2006
- 2006-06-29 CN CN2006100283701A patent/CN1875944B/zh active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101229131B (zh) * | 2008-01-30 | 2010-06-02 | 中国科学院上海药物研究所 | 具有降低喜树碱类药物胃肠毒性的新型纳米微粒制剂 |
CN103772696A (zh) * | 2014-01-06 | 2014-05-07 | 济南大学 | 一种羟基喜树碱的聚甘油脂肪酸酯衍生物 |
CN103772696B (zh) * | 2014-01-06 | 2015-12-02 | 济南大学 | 一种羟基喜树碱的聚甘油脂肪酸酯衍生物 |
CN108567742A (zh) * | 2017-03-14 | 2018-09-25 | 中国科学院上海药物研究所 | Sn38脂质组合物、其制备方法和用途 |
CN108567742B (zh) * | 2017-03-14 | 2021-05-18 | 中国科学院上海药物研究所 | Sn38脂质组合物、其制备方法和用途 |
Also Published As
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CN1875944B (zh) | 2011-01-05 |
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Effective date of registration: 20190326 Address after: 518035 Health Yuan Pharmaceutical Group Building, No. 17 Longshan Road, North District, Nanshan High-tech Zone, Shenzhen City, Guangdong Province Patentee after: Jiankangyuan Pharmaceutical Group Co., Ltd. Address before: 200031 No. 294, Taiyuan Road, Shanghai Patentee before: Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
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EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20061213 Assignee: Ningbo ningrong Biological Medicine Co., Ltd. Assignor: Jiankangyuan Pharmaceutical Group Co., Ltd. Contract record no.: X2019990000020 Denomination of invention: A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof Granted publication date: 20110105 License type: Exclusive License Record date: 20190826 |
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EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20061213 Assignee: Ningbo ningrong Biological Medicine Co., Ltd. Assignor: Jiankangyuan Pharmaceutical Group Co., Ltd. Contract record no.: X2019990000020 Denomination of invention: A carbowax modified stealthy liposome nanosphere of hydroxycamtothecine and preparation method thereof Granted publication date: 20110105 License type: Exclusive License Record date: 20190826 |
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EE01 | Entry into force of recordation of patent licensing contract |