CN1867572B - 蛋白酶体抑制剂及其使用方法 - Google Patents
蛋白酶体抑制剂及其使用方法 Download PDFInfo
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- CN1867572B CN1867572B CN2004800301520A CN200480030152A CN1867572B CN 1867572 B CN1867572 B CN 1867572B CN 2004800301520 A CN2004800301520 A CN 2004800301520A CN 200480030152 A CN200480030152 A CN 200480030152A CN 1867572 B CN1867572 B CN 1867572B
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- amino
- methylbutyl
- methyl
- carbonyl
- imino
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 1236
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 353
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| UA (1) | UA88771C2 (ru) |
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| CN105837608B (zh) * | 2007-08-06 | 2018-06-08 | 米伦纽姆医药公司 | 蛋白酶体抑制剂及其组合物和用途 |
| GEP20125599B (en) * | 2007-08-06 | 2012-08-10 | Millennium Pharm Inc | Proteasome inhibitors |
| CN102961387B (zh) * | 2007-08-06 | 2016-04-27 | 米伦纽姆医药公司 | 蛋白酶体抑制剂 |
| DK2730581T3 (en) * | 2008-06-17 | 2016-08-15 | Millennium Pharm Inc | Boronate Ester Compounds and Pharmaceutical Compositions thereof. |
| CN101638414B (zh) * | 2008-07-30 | 2014-01-08 | 江苏先声药物研究有限公司 | 肽硼酸及其酯类化合物、制备方法及其用途 |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| CN101747354B (zh) * | 2008-12-04 | 2014-08-13 | 江苏先声药物研究有限公司 | 一类β氨基酸组成的二肽硼酸及其酯类化合物、制备方法及其用途 |
| CA2785300A1 (en) * | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
| CN102892291A (zh) * | 2010-03-31 | 2013-01-23 | 米伦纽姆医药公司 | 1-氨基-2-环丙基乙硼酸衍生物 |
| RU2717558C2 (ru) * | 2014-10-01 | 2020-03-24 | Мерк Патент Гмбх | Производные бороновой кислоты |
| CN106588965A (zh) | 2015-10-15 | 2017-04-26 | 北京大学 | 脲拟肽硼酸化合物及其药物组合物、制备方法和用途 |
| WO2017198194A1 (zh) * | 2016-05-19 | 2017-11-23 | 成都奥璟生物科技有限公司 | 一种硼酸和硼酸酯类化合物及其应用 |
| PL3571208T3 (pl) * | 2017-01-18 | 2021-09-20 | Principia Biopharma Inc. | Inhibitory immunoproteasomu |
| TW201831191A (zh) * | 2017-01-23 | 2018-09-01 | 大陸商成都奥璟生物科技有限公司 | 一種新的硼酸衍生物及其藥物組合物 |
| CN114437119A (zh) * | 2020-10-30 | 2022-05-06 | 苏州开拓药业股份有限公司 | 一种c-Myc蛋白抑制剂及其制备方法和用途 |
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Non-Patent Citations (2)
| Title |
|---|
| SIMOV BILJANA PERIC ET AL.Chiral carbanions. Part 4: borylation of (trimethylsilyl)methylN |
| SIMOV, BILJANA PERIC ET AL.Chiral carbanions. Part 4: borylation of (trimethylsilyl)methylN,N-dialkulcarbamates-diastereoselectivity and structuralstudies.synthesis 16.2004,(16),2705. * |
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| AR045381A1 (es) | 2005-10-26 |
| TW200529810A (en) | 2005-09-16 |
| TWI345465B (en) | 2011-07-21 |
| UA88771C2 (ru) | 2009-11-25 |
| AR095249A2 (es) | 2015-09-30 |
| MY162518A (en) | 2017-06-15 |
| PE20050360A1 (es) | 2005-06-10 |
| CN1867572A (zh) | 2006-11-22 |
| ZA200601293B (en) | 2009-09-30 |
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