CN1829688A - 用于制备他汀类尤其是阿托伐他汀的方法和中间化合物 - Google Patents
用于制备他汀类尤其是阿托伐他汀的方法和中间化合物 Download PDFInfo
- Publication number
- CN1829688A CN1829688A CNA2004800213820A CN200480021382A CN1829688A CN 1829688 A CN1829688 A CN 1829688A CN A2004800213820 A CNA2004800213820 A CN A2004800213820A CN 200480021382 A CN200480021382 A CN 200480021382A CN 1829688 A CN1829688 A CN 1829688A
- Authority
- CN
- China
- Prior art keywords
- compound
- group
- formula
- represent
- preferred
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0317393.7 | 2003-07-25 | ||
GB0317393A GB0317393D0 (en) | 2003-07-25 | 2003-07-25 | Process and compounds |
GB0406760.9 | 2004-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1829688A true CN1829688A (zh) | 2006-09-06 |
CN100503565C CN100503565C (zh) | 2009-06-24 |
Family
ID=27772631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800213820A Expired - Fee Related CN100503565C (zh) | 2003-07-25 | 2004-07-23 | 用于制备他汀类尤其是阿托伐他汀的方法和中间化合物 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN100503565C (zh) |
GB (1) | GB0317393D0 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101215297B (zh) * | 2008-01-14 | 2011-09-14 | 湖南师范大学 | 他汀-双膦酸偶合物及其制备方法和应用 |
CN102387800A (zh) * | 2009-03-10 | 2012-03-21 | 莱德克斯制药有限公司 | 瑞舒伐他汀和阿托伐他汀衍生物 |
CN102387799A (zh) * | 2009-03-10 | 2012-03-21 | 莱德克斯制药有限公司 | 阿托伐他汀邻位羟基内醚作为药物的用途 |
CN103384659A (zh) * | 2011-02-21 | 2013-11-06 | 公益财团法人微生物化学研究会 | 硫代酰胺化合物、生产硫代酰胺化合物的方法、生产 [(4r,6r)-6-氨乙基-1,3-二噁烷-4-基]乙酸酯衍生物的方法和生产阿托伐他汀的方法 |
-
2003
- 2003-07-25 GB GB0317393A patent/GB0317393D0/en not_active Ceased
-
2004
- 2004-07-23 CN CNB2004800213820A patent/CN100503565C/zh not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101215297B (zh) * | 2008-01-14 | 2011-09-14 | 湖南师范大学 | 他汀-双膦酸偶合物及其制备方法和应用 |
CN102387800A (zh) * | 2009-03-10 | 2012-03-21 | 莱德克斯制药有限公司 | 瑞舒伐他汀和阿托伐他汀衍生物 |
CN102387799A (zh) * | 2009-03-10 | 2012-03-21 | 莱德克斯制药有限公司 | 阿托伐他汀邻位羟基内醚作为药物的用途 |
CN103224490A (zh) * | 2009-03-10 | 2013-07-31 | 莱德克斯制药有限公司 | 瑞舒伐他汀和阿托伐他汀衍生物 |
CN102387800B (zh) * | 2009-03-10 | 2013-11-27 | 莱德克斯制药有限公司 | 瑞舒伐他汀和阿托伐他汀衍生物 |
CN102387799B (zh) * | 2009-03-10 | 2015-07-22 | 莱德克斯制药有限公司 | 阿托伐他汀邻位羟基内醚作为药物的用途 |
CN103384659A (zh) * | 2011-02-21 | 2013-11-06 | 公益财团法人微生物化学研究会 | 硫代酰胺化合物、生产硫代酰胺化合物的方法、生产 [(4r,6r)-6-氨乙基-1,3-二噁烷-4-基]乙酸酯衍生物的方法和生产阿托伐他汀的方法 |
CN103384659B (zh) * | 2011-02-21 | 2015-11-25 | 公益财团法人微生物化学研究会 | 硫代酰胺化合物及生产该化合物、[(4r,6r)-6-氨乙基-1,3-二噁烷-4-基]乙酸酯衍生物和阿托伐他汀的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100503565C (zh) | 2009-06-24 |
GB0317393D0 (en) | 2003-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1097054C (zh) | 三环类吡唑衍生物及其组合物 | |
CN1106396A (zh) | 用于制备具有抗糖尿病和抗肥胖症性能的芳香氨基醇衍生物的中间化合物 | |
CN1608057A (zh) | 制备西太普兰的方法 | |
CN1869036A (zh) | 7-取代-3-氯吡咯并[3,4-b]吡啶化合物 | |
CN1680363A (zh) | 2-(6-取代的1,3-二噁烷-4-基)乙酸衍生物的制备方法 | |
CN1155568C (zh) | 3-链烷酰基-和3-烷基吲哚的制备方法 | |
CN1944406A (zh) | 吲哚类杂环化合物和中间体、以及合成方法 | |
CN1087735C (zh) | 1-(卤代芳基)杂环农药化合物的制备方法 | |
CN1829688A (zh) | 用于制备他汀类尤其是阿托伐他汀的方法和中间化合物 | |
CN1898255A (zh) | 制备吡啶衍生物的方法 | |
CN1037147A (zh) | N-环丙基苯胺及其在制备1-环丙基喹诺酮羧酸和其衍生物中的应用 | |
JP2008533128A (ja) | Paal−Knorr縮合を用いた、アトルバスタチン中間体の製造 | |
CN1785967A (zh) | 制备氨基甲酸酯衍生物的方法 | |
CN1946687A (zh) | 阿托伐他汀叔丁基酯的多晶型物及其作为中间体在制备阿托伐他汀中的应用 | |
CN100345821C (zh) | 制备碘帕醇的方法和其中的新中间体 | |
HRP20051020A2 (hr) | Postupak i međuspojevi korisni u dobivanju statina, posebice atorvastatin | |
CN1130361C (zh) | 异噁唑烷二酮化合物的制备方法 | |
CN1247562C (zh) | 制备螺环季酮酸衍生物的方法 | |
CN1232030A (zh) | 辛伐他汀和/或其衍生物的制备方法 | |
CN1675200A (zh) | 制备5-( 4-氟苯基 )-1-[ 2-( ( 2 r , 4 r )-4-羟基-6-氧代-四氢-吡喃-2-基)乙基]-2-异丙基-4-苯基-1h-吡咯-3-羧酸苯基酰胺的方法 | |
CN1100143A (zh) | 酶催化拆分2-哌啶羟酸烷基酯及所得产物的应用 | |
CN1255404C (zh) | 制备取代的咪唑并吡啶化合物的方法 | |
CN1440376A (zh) | 制备双环1,3-二酮的方法 | |
EP2665721B1 (en) | Methyltetrazole sulfides and sulfones | |
CN1466571A (zh) | 制备△1-吡咯啉的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CI02 | Correction of invention patent application |
Correction item: Priority Correct: 2004.03.26 GB 0406760.9 False: Lack of priority second Number: 36 Page: The title page Volume: 22 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: PRIORITY; FROM: MISSING THE SECOND ARTICLE OF PRIORITY TO: 2004.3.26 GB 0406760.9 |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BRADFORD PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: PIRAMA HEALTH BRITAIN CO., LTD. Effective date: 20101119 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: PIRAMA HEALTH BRITAIN CO., LTD. Free format text: FORMER NAME: AVECIA LTD. |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: NORTHUMBERLAND, ENGLAND TO: LANCASHIRE, ENGLAND |
|
CP03 | Change of name, title or address |
Address after: Great Britain Patentee after: Health care UK Ltd. Address before: University of Manchester Patentee before: NPIL PHARMACEUTICALS UK LTD. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20101119 Address after: Lancashire Patentee after: Bradford Pharmaceutical Co.,Ltd. Address before: Great Britain Patentee before: Health care UK Ltd. |
|
ASS | Succession or assignment of patent right |
Owner name: REDEX PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: BRADFORD PHARMACEUTICAL CO., LTD. Effective date: 20120222 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20120222 Address after: University of Manchester Patentee after: REDEX Pharmaceutical Co.,Ltd. Address before: Lancashire Patentee before: Bradford Pharmaceutical Co.,Ltd. |
|
C56 | Change in the name or address of the patentee |
Owner name: REDX PHARMA PLC Free format text: FORMER NAME: REDEX PHARMACEUTICAL CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: University of Manchester Patentee after: REDEX pharmaceutical Public Co.,Ltd. Address before: University of Manchester Patentee before: REDEX Pharmaceutical Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090624 Termination date: 20160723 |