CN1764450A - 结晶型n－甲酰基羟胺化合物 - Google Patents

结晶型n－甲酰基羟胺化合物 Download PDF

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Publication number
CN1764450A
CN1764450A CNA2004800078725A CN200480007872A CN1764450A CN 1764450 A CN1764450 A CN 1764450A CN A2004800078725 A CNA2004800078725 A CN A2004800078725A CN 200480007872 A CN200480007872 A CN 200480007872A CN 1764450 A CN1764450 A CN 1764450A
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CN
China
Prior art keywords
alkyl
formula
hydrogen
aryl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800078725A
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English (en)
Chinese (zh)
Inventor
M·米勒
H·刘
J·S·巴杰瓦
J·斯莱德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33131903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1764450(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1764450A publication Critical patent/CN1764450A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2004800078725A 2003-04-02 2004-04-01 结晶型n－甲酰基羟胺化合物 Pending CN1764450A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45972603P 2003-04-02 2003-04-02
US60/459,726 2003-04-02

Publications (1)

Publication Number Publication Date
CN1764450A true CN1764450A (zh) 2006-04-26

Family

ID=33131903

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800078725A Pending CN1764450A (zh) 2003-04-02 2004-04-01 结晶型n－甲酰基羟胺化合物

Country Status (25)

Country Link
US (1) US20070135353A1 (https=)
EP (1) EP1613305A1 (https=)
JP (1) JP2006522054A (https=)
KR (1) KR20060002915A (https=)
CN (1) CN1764450A (https=)
AR (1) AR043804A1 (https=)
AU (1) AU2004226815B2 (https=)
BR (1) BRPI0409009A (https=)
CA (1) CA2520682A1 (https=)
CL (1) CL2004000705A1 (https=)
CO (1) CO5630028A2 (https=)
EC (1) ECSP056043A (https=)
IS (1) IS8093A (https=)
MA (1) MA27763A1 (https=)
MX (1) MXPA05010610A (https=)
MY (1) MY136854A (https=)
NO (1) NO20055097L (https=)
NZ (1) NZ542432A (https=)
PE (1) PE20050392A1 (https=)
RU (1) RU2005133660A (https=)
SG (1) SG166681A1 (https=)
TN (1) TNSN05248A1 (https=)
TW (1) TW200427458A (https=)
WO (1) WO2004087133A1 (https=)
ZA (1) ZA200507179B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017193924A1 (zh) * 2016-05-11 2017-11-16 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1406893B1 (en) 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. Pyrrolidine bicyclic compounds
ATE417826T1 (de) 2002-09-19 2009-01-15 Novartis Pharma Gmbh Verfahren zur herstellung von zwischenprodukten
MXPA05008842A (es) 2003-02-21 2005-10-05 Novartis Ag Proceso quimico.
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282986A (en) * 1960-10-06 1966-11-01 Merck & Co Inc N-acylated hydroxamic acids and derivatives thereof
DK1052984T3 (da) * 1998-02-07 2004-09-20 Vernalis Oxford Ltd Antibakterielle midler
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017193924A1 (zh) * 2016-05-11 2017-11-16 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用
US10738028B2 (en) 2016-05-11 2020-08-11 Rudong Ruien Pharmaceutical Technology Co. Ltd Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor

Also Published As

Publication number Publication date
NO20055097L (no) 2005-12-22
CA2520682A1 (en) 2004-10-14
US20070135353A1 (en) 2007-06-14
RU2005133660A (ru) 2006-06-10
AU2004226815B2 (en) 2007-07-19
NZ542432A (en) 2009-04-30
PE20050392A1 (es) 2005-06-19
TNSN05248A1 (en) 2007-06-11
MXPA05010610A (es) 2005-11-23
BRPI0409009A (pt) 2006-03-28
IS8093A (is) 2005-10-27
AU2004226815A1 (en) 2004-10-14
CO5630028A2 (es) 2006-04-28
SG166681A1 (en) 2010-12-29
CL2004000705A1 (es) 2005-01-14
WO2004087133A1 (en) 2004-10-14
MA27763A1 (fr) 2006-02-01
MY136854A (en) 2008-11-28
ZA200507179B (en) 2006-04-26
NO20055097D0 (no) 2005-11-01
KR20060002915A (ko) 2006-01-09
ECSP056043A (es) 2006-01-27
JP2006522054A (ja) 2006-09-28
TW200427458A (en) 2004-12-16
EP1613305A1 (en) 2006-01-11
AR043804A1 (es) 2005-08-10

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Effective date of abandoning: 20060426

C20 Patent right or utility model deemed to be abandoned or is abandoned