CN1759109A - 取代的苯甲酰基脲基吡啶基－哌啶－和－吡咯烷甲酸衍生物,它们的制备方法和用途 - Google Patents

取代的苯甲酰基脲基吡啶基－哌啶－和－吡咯烷甲酸衍生物,它们的制备方法和用途 Download PDF

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Publication number
CN1759109A
CN1759109A CNA2004800062407A CN200480006240A CN1759109A CN 1759109 A CN1759109 A CN 1759109A CN A2004800062407 A CNA2004800062407 A CN A2004800062407A CN 200480006240 A CN200480006240 A CN 200480006240A CN 1759109 A CN1759109 A CN 1759109A
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CN
China
Prior art keywords
alkyl
agonists
compounds
compound
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800062407A
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English (en)
Chinese (zh)
Inventor
K·舍纳芬格
D·卡德莱特
E·德福萨
A·赫林
T·克拉邦德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Publication of CN1759109A publication Critical patent/CN1759109A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2004800062407A 2003-03-07 2004-02-21 取代的苯甲酰基脲基吡啶基－哌啶－和－吡咯烷甲酸衍生物,它们的制备方法和用途 Pending CN1759109A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10309929A DE10309929B4 (de) 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
DE10309929.8 2003-03-07

Publications (1)

Publication Number Publication Date
CN1759109A true CN1759109A (zh) 2006-04-12

Family

ID=32945839

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800062407A Pending CN1759109A (zh) 2003-03-07 2004-02-21 取代的苯甲酰基脲基吡啶基－哌啶－和－吡咯烷甲酸衍生物,它们的制备方法和用途

Country Status (18)

Country Link
EP (1) EP1603895B1 (enExample)
JP (1) JP2006519795A (enExample)
KR (1) KR20050108487A (enExample)
CN (1) CN1759109A (enExample)
AT (1) ATE386735T1 (enExample)
AU (1) AU2004218267A1 (enExample)
BR (1) BRPI0408148A (enExample)
CA (1) CA2518322A1 (enExample)
CO (1) CO5690587A2 (enExample)
DE (2) DE10309929B4 (enExample)
HR (1) HRP20050779A2 (enExample)
MA (1) MA27745A1 (enExample)
MX (1) MXPA05009122A (enExample)
NO (1) NO20054418L (enExample)
PL (1) PL377293A1 (enExample)
RU (1) RU2005131011A (enExample)
WO (1) WO2004078743A1 (enExample)
ZA (1) ZA200506119B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006055435A1 (en) 2004-11-15 2006-05-26 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
WO2006053274A2 (en) 2004-11-15 2006-05-18 Bristol-Myers Squibb Company 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
MX2012003389A (es) * 2009-10-06 2012-04-10 Bristol Myers Squibb Co Moduladores de gpr40 de pirrolidina.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034004A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
DE10116768A1 (de) * 2001-04-04 2002-10-10 Aventis Pharma Gmbh Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2411082A1 (en) * 2000-06-09 2002-12-05 Aventis Pharma Deutschland Gmbh Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament
DE10125567B4 (de) * 2001-05-25 2004-08-26 Aventis Pharma Deutschland Gmbh Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
IL164249A0 (en) * 2002-04-11 2005-12-18 Aventis Pharma Gmbh Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use
CA2493373A1 (en) * 2002-07-11 2004-01-22 Aventis Pharma Deutschland Gmbh Urea-substituted and urethane-substituted acylureas, methods for the production thereof and their use as medicaments
AU2003249937A1 (en) * 2002-07-12 2004-02-02 Sanofi-Aventis Deutschland Gmbh Heterocyclically substituted benzoylureas, method for their production and their use as medicaments

Also Published As

Publication number Publication date
MA27745A1 (fr) 2006-02-01
EP1603895A1 (de) 2005-12-14
DE10309929B4 (de) 2006-02-23
BRPI0408148A (pt) 2006-03-01
PL377293A1 (pl) 2006-01-23
CA2518322A1 (en) 2004-09-16
CO5690587A2 (es) 2006-10-31
JP2006519795A (ja) 2006-08-31
RU2005131011A (ru) 2006-05-10
KR20050108487A (ko) 2005-11-16
WO2004078743A1 (de) 2004-09-16
HRP20050779A2 (en) 2006-10-31
ZA200506119B (en) 2006-11-29
EP1603895B1 (de) 2008-02-20
MXPA05009122A (es) 2005-10-20
AU2004218267A1 (en) 2004-09-16
NO20054418L (no) 2005-09-23
ATE386735T1 (de) 2008-03-15
DE502004006253D1 (de) 2008-04-03
DE10309929A1 (de) 2004-12-02

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