CN1754002B - 涉及痘病毒和癌的组合物及制备方法 - Google Patents
涉及痘病毒和癌的组合物及制备方法 Download PDFInfo
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- CN1754002B CN1754002B CN038237199A CN03823719A CN1754002B CN 1754002 B CN1754002 B CN 1754002B CN 038237199 A CN038237199 A CN 038237199A CN 03823719 A CN03823719 A CN 03823719A CN 1754002 B CN1754002 B CN 1754002B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24161—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24161—Methods of inactivation or attenuation
- C12N2710/24162—Methods of inactivation or attenuation by genetic engineering
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40285702P | 2002-08-12 | 2002-08-12 | |
| US60/402,857 | 2002-08-12 | ||
| PCT/US2003/025141 WO2004014314A2 (en) | 2002-08-12 | 2003-08-11 | Methods and compositions concerning poxviruses and cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101583381A Division CN101912421A (zh) | 2002-08-12 | 2003-08-11 | 涉及痘病毒和癌的方法及组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1754002A CN1754002A (zh) | 2006-03-29 |
| CN1754002B true CN1754002B (zh) | 2010-09-08 |
Family
ID=31715904
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101583381A Pending CN101912421A (zh) | 2002-08-12 | 2003-08-11 | 涉及痘病毒和癌的方法及组合物 |
| CN038237199A Expired - Lifetime CN1754002B (zh) | 2002-08-12 | 2003-08-11 | 涉及痘病毒和癌的组合物及制备方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101583381A Pending CN101912421A (zh) | 2002-08-12 | 2003-08-11 | 涉及痘病毒和癌的方法及组合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20060099224A1 (enExample) |
| EP (4) | EP2269618A1 (enExample) |
| JP (2) | JP4796299B2 (enExample) |
| KR (3) | KR20130012595A (enExample) |
| CN (2) | CN101912421A (enExample) |
| AU (2) | AU2003258168B2 (enExample) |
| CA (2) | CA2818693C (enExample) |
| ES (1) | ES2444699T3 (enExample) |
| WO (1) | WO2004014314A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12226440B2 (en) | 2017-10-31 | 2025-02-18 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
| US12403165B2 (en) | 2020-11-19 | 2025-09-02 | KaliVir Immunotherapeutcs, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7285526B2 (en) * | 1995-07-14 | 2007-10-23 | Meiogen Biotechnology Corporation | Interferon antagonists useful for the treatment of interferon related diseases |
| GB0109515D0 (en) * | 2001-04-17 | 2001-06-06 | Neg Micon As | A method for transporting a set of large longitudinal items, a package system to be used by the method and use of such a package system |
| EP1281767A3 (en) * | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Light emitting microorganisms and cells for diagnosis and therapy of tumors |
| EP2269618A1 (en) | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | An oncolytic vaccinia virus for use in combination with a chemotherapy for treating cancer. |
| MXPA05013879A (es) * | 2003-06-18 | 2006-06-27 | Genelux Corp | Virus de la vaccinia recombinantes modificados y otros microorganismos, y usos de los mismos. |
| CN102357104B (zh) * | 2005-03-07 | 2016-01-27 | 罗巴斯研究机构 | 粘液瘤病毒与雷帕霉素的组合在治疗性处理中的应用 |
| WO2007030668A2 (en) * | 2005-09-07 | 2007-03-15 | Jennerex Biotherapeutics Ulc | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| JP5164849B2 (ja) * | 2005-11-24 | 2013-03-21 | アイキュリス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コムパニー・コマンディットゲゼルシャフト | 癌の処置用の生物化学療法としての古典的細胞傷害性化学療法剤と組み合わせたパラポックスウイルス |
| GB0605761D0 (en) * | 2006-03-22 | 2006-05-03 | Imp Innovations Ltd | Anti-inflammatory proteins and improved vaccines |
| BRPI0712158B8 (pt) * | 2006-06-20 | 2021-05-25 | Transgene Sa | processo para produzir uma composição de poxvírus de tipo selvagem, atenuado e/ou recombinante sem especificidade de infecção visada |
| US20100086522A1 (en) * | 2006-07-18 | 2010-04-08 | Ottawa Health Research Institute | Disparate suicide carrier cells for tumor targeting of promiscuous oncolytic viruses |
| US8052968B2 (en) | 2006-10-16 | 2011-11-08 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
| KR20080084528A (ko) * | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
| JP5213075B2 (ja) | 2007-06-15 | 2013-06-19 | ジェネラックス・コーポレイション | 腫瘍の画像化および/または処置のための微生物 |
| JP2010533718A (ja) * | 2007-07-18 | 2010-10-28 | ジェネラックス・コーポレイション | 腫瘍溶解性ウイルス治療に付随する副作用の処置もしくは改善用医薬の製造における化学治療剤の使用 |
| WO2009052426A2 (en) * | 2007-10-17 | 2009-04-23 | The Ohio State University | Oncolytic virus |
| US8450106B2 (en) * | 2007-10-17 | 2013-05-28 | The Ohio State University Research Foundation | Oncolytic virus |
| WO2009054996A2 (en) * | 2007-10-25 | 2009-04-30 | Genelux Corporation | Systems and methods for viral therapy |
| WO2009082594A2 (en) * | 2007-11-26 | 2009-07-02 | Fox Chase Cancer Center | Secreted/cell bound poxvirus proteins and methods of use thereof as vaccines and anti-viral agents |
| US20110044952A1 (en) * | 2007-11-27 | 2011-02-24 | Ottawa Health Research Institute | Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors |
| US20110086005A1 (en) * | 2008-05-27 | 2011-04-14 | Oncolytics Biotech Inc. | Modulating interstitial pressure and oncolytic viral delivery and distribution |
| WO2010124393A1 (en) * | 2009-04-30 | 2010-11-04 | National Research Council Of Canada | Anticancer agent comprising a yatapoxvirus mutant and uses thereof |
| JP5879266B2 (ja) | 2009-09-14 | 2016-03-08 | シラジェン バイオセラピューティクス インコーポレイテッド | 腫瘍崩壊性ワクシニアウイルスの併用癌療法 |
| CA2781397A1 (en) * | 2009-11-20 | 2011-05-26 | Inviragen, Inc. | Compositions, methods and uses for poxvirus elements in vaccine constructs |
| US20110288545A1 (en) * | 2010-04-22 | 2011-11-24 | Old Dominion University Research Foundation | Method and Device for Ablation of Cancer and Resistance to New Cancer Growth |
| CA2824277C (en) * | 2011-01-04 | 2021-08-31 | Jennerex, Inc. | Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| CN102747103A (zh) * | 2011-04-20 | 2012-10-24 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于a52l基因和b8r基因双缺失的复制型痘苗病毒的艾滋病疫苗 |
| CN103732236B (zh) | 2011-08-05 | 2017-09-15 | 新罗杰公司 | 用于生产痘苗病毒的方法和组合物 |
| KR101370620B1 (ko) | 2011-08-05 | 2014-03-06 | 한국생명공학연구원 | 다람쥐폭스바이러스를 유효성분으로 포함하는 암 예방 및 치료용 약학적 조성물 |
| FI20115914L (fi) * | 2011-09-16 | 2013-03-17 | Oncos Therapeutics Ltd | Muunnettu onkolyyttinen virus |
| WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
| US20150250837A1 (en) * | 2012-09-20 | 2015-09-10 | Morningside Technology Ventures Ltd. | Oncolytic virus encoding pd-1 binding agents and uses of the same |
| WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
| WO2014110092A1 (en) * | 2013-01-08 | 2014-07-17 | Humabs Biomed Sa | Methods of generating robust passive and active immune responses |
| PE20160673A1 (es) * | 2013-08-22 | 2016-07-21 | Univ Of Pittsburgh - Of The Commonwealth System Of Higher Education | Terapias inmuno-oncoliticas |
| KR101540319B1 (ko) * | 2013-10-01 | 2015-07-30 | 한국생명공학연구원 | cyb5R3 유전자 또는 단백질을 유효성분으로 포함하는 암 예방 및 치료용 약학적 조성물 |
| WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| AU2015243297B2 (en) | 2014-04-10 | 2020-10-15 | Transgene S.A. | Poxviral oncolytic vectors |
| WO2016011336A1 (en) * | 2014-07-17 | 2016-01-21 | Western Michigan University Research Foundation | Composition for treating cancerous cells and a method therefor |
| EP3310383B1 (en) | 2015-06-19 | 2020-02-19 | Sillajen, Inc. | Compositions and methods for viral embolization |
| AU2016320355B2 (en) * | 2015-09-08 | 2020-10-08 | Sillajen, Inc. | Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof |
| MX2019001919A (es) * | 2016-08-19 | 2019-09-04 | Sementis Ltd | Vacunas virales. |
| JP2019528753A (ja) | 2016-09-21 | 2019-10-17 | スティーブン エイチ. ソーン, | 高移動度グループboxi突然変異体 |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
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| JP7274138B2 (ja) * | 2017-11-30 | 2023-05-16 | アステラス製薬株式会社 | Scr欠失ワクシニアウイルス |
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| KR20210091740A (ko) * | 2018-11-06 | 2021-07-22 | 카리디 바이오테라퓨틱스, 인크. | 세포-매개된 종양용해 바이러스 요법용 향상된 시스템 |
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| JP7737141B2 (ja) * | 2019-05-14 | 2025-09-10 | 国立大学法人鳥取大学 | 細胞融合を誘導するワクシニアウイルス及びその利用 |
| CA3145907A1 (en) | 2019-08-09 | 2021-02-18 | Toshio Murakami | Oncolytic vaccinia virus |
| WO2021071534A1 (en) * | 2019-10-08 | 2021-04-15 | Icell Kealex Therapeutics | Mutant vaccinia viruses and use thereof |
| US11110165B2 (en) | 2019-10-10 | 2021-09-07 | Ricardo Rosales Ledezma | Therapeutic vaccine for the treatment of papillomavirus lesions |
| JP7625589B2 (ja) * | 2019-10-16 | 2025-02-03 | カリヴィル イムノセラピューティクス, インコーポレイテッド | 改変細胞外エンベロープウイルス |
| US20230002465A1 (en) * | 2019-11-20 | 2023-01-05 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Vaccinia viruses and methods for using vaccinia viruses |
| AU2020402303A1 (en) * | 2019-12-12 | 2022-06-09 | Ignite Immunotherapy, Inc. | Variant oncolytic vaccinia virus and methods of use thereof |
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| US12226440B2 (en) | 2017-10-31 | 2025-02-18 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
| US12318419B2 (en) | 2017-10-31 | 2025-06-03 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
| US12472217B2 (en) | 2017-10-31 | 2025-11-18 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
| US12403165B2 (en) | 2020-11-19 | 2025-09-02 | KaliVir Immunotherapeutcs, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
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| EP1578396A4 (en) | 2007-01-17 |
| KR20130012595A (ko) | 2013-02-04 |
| CN1754002A (zh) | 2006-03-29 |
| CA2818693A1 (en) | 2004-02-19 |
| AU2003258168B2 (en) | 2009-10-29 |
| US8986674B2 (en) | 2015-03-24 |
| JP2006506974A (ja) | 2006-03-02 |
| EP1578396A2 (en) | 2005-09-28 |
| CA2494844C (en) | 2013-10-15 |
| AU2010200333B2 (en) | 2012-09-13 |
| CA2494844A1 (en) | 2004-02-19 |
| US20090004723A1 (en) | 2009-01-01 |
| AU2003258168A1 (en) | 2004-02-25 |
| KR20050074436A (ko) | 2005-07-18 |
| CA2818693C (en) | 2016-05-17 |
| WO2004014314A3 (en) | 2005-09-29 |
| EP2269618A1 (en) | 2011-01-05 |
| ES2444699T3 (es) | 2014-02-26 |
| WO2004014314A2 (en) | 2004-02-19 |
| EP2044948B1 (en) | 2013-10-30 |
| US8329164B2 (en) | 2012-12-11 |
| EP2044948A1 (en) | 2009-04-08 |
| US20060099224A1 (en) | 2006-05-11 |
| AU2010200333A1 (en) | 2010-02-18 |
| EP2269619A1 (en) | 2011-01-05 |
| KR20120002613A (ko) | 2012-01-06 |
| US20130183271A1 (en) | 2013-07-18 |
| HK1130196A1 (en) | 2009-12-24 |
| JP2011078427A (ja) | 2011-04-21 |
| CN101912421A (zh) | 2010-12-15 |
| JP4796299B2 (ja) | 2011-10-19 |
| KR101170653B1 (ko) | 2012-08-03 |
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