CN1726224A - 嵌合αQ－Gustducin G－蛋白 - Google Patents

嵌合αQ－Gustducin G－蛋白 Download PDF

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Publication number
CN1726224A
CN1726224A CNA2003801065075A CN200380106507A CN1726224A CN 1726224 A CN1726224 A CN 1726224A CN A2003801065075 A CNA2003801065075 A CN A2003801065075A CN 200380106507 A CN200380106507 A CN 200380106507A CN 1726224 A CN1726224 A CN 1726224A
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CN
China
Prior art keywords
protein
chimeric
cell
albumen
gustducin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CNA2003801065075A
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English (en)
Chinese (zh)
Inventor
J·P·斯莱克
T·S·麦克拉斯基
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Givaudan SA
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Givaudan SA
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Filing date
Publication date
Application filed by Givaudan SA filed Critical Givaudan SA
Publication of CN1726224A publication Critical patent/CN1726224A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2003801065075A 2002-12-18 2003-12-17 嵌合αQ－Gustducin G－蛋白 Pending CN1726224A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43479002P 2002-12-18 2002-12-18
US60/434,790 2002-12-18

Publications (1)

Publication Number Publication Date
CN1726224A true CN1726224A (zh) 2006-01-25

Family

ID=32595305

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801065075A Pending CN1726224A (zh) 2002-12-18 2003-12-17 嵌合αQ－Gustducin G－蛋白

Country Status (10)

Country Link
US (2) US7919236B2 (https=)
EP (1) EP1581555B1 (https=)
JP (2) JP4654038B2 (https=)
CN (1) CN1726224A (https=)
AT (1) ATE393778T1 (https=)
AU (1) AU2003286069A1 (https=)
CA (1) CA2507387A1 (https=)
DE (1) DE60320682T2 (https=)
ES (1) ES2305536T3 (https=)
WO (1) WO2004055048A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105339384A (zh) * 2013-05-10 2016-02-17 百事可乐公司 作为鉴别潜在味觉调节剂的模型的细胞
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
CN119193656A (zh) * 2024-09-24 2024-12-27 上海交通大学 一种响应鲜味信号的酵母细胞模型及其制备方法与应用

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US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
AU2003286069A1 (en) * 2002-12-18 2004-07-09 Givaudan Sa Chimeric alpha q-gustducin g-proteins
WO2006046854A2 (en) 2004-10-29 2006-05-04 Quest International B.V. Flavour modulating substances
BRPI0518075B8 (pt) 2004-10-29 2017-05-16 Quest Int Services B V composição flavorizante, produto, e, processo de melhorar o flavor de um alimento, de uma bebida ou de um produto farmacêutico
DE602005015849D1 (de) 2005-09-02 2009-09-17 Givaudan Nederland Services B Geschmackverstärker
WO2007121604A2 (en) 2006-04-20 2007-11-01 Givaudan Sa Method relating to sweetness enhancement
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
JP2009533065A (ja) * 2006-04-20 2009-09-17 ジボダン エス エー 味覚物質同定のための機能的方法
ATE444280T1 (de) 2006-05-05 2009-10-15 Givaudan Nederland Services B Zusammensetzung zur verbesserung von geschmack
US8039233B2 (en) * 2007-01-18 2011-10-18 Givaudan S.A. Nucleic acid sequences and their use in methods to identify umami modulatiors
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
EP2137322B1 (en) * 2007-03-30 2013-02-27 Givaudan SA Methods to identify tas2r modulators
KR20100131969A (ko) * 2007-12-10 2010-12-16 메타프로테오믹스, 엘엘씨 암, 혈관신생 및 이와 관련된 염증 경로의 치환된 1,3-시클로펜타디온 다중-표적 단백질 키나아제 조절제
EP2108954A1 (en) 2008-04-10 2009-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof
US8546085B2 (en) * 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
JP5576653B2 (ja) * 2008-12-26 2014-08-20 サントリー食品インターナショナル株式会社 環状ジペプチド含有飲料
EP2924112A1 (en) * 2009-02-02 2015-09-30 Chromocell Corporation Novel cell lines and methods
US20130123135A1 (en) 2010-05-07 2013-05-16 Jay Patrick Slack Methods To Identify Modulators of TAS2R48 Receptors
US20130115624A1 (en) 2010-05-07 2013-05-09 Givaudan S.A. Methods To Identify Modulators
JP5906013B2 (ja) * 2010-12-10 2016-04-20 花王株式会社 苦味抑制剤の評価・選択方法
EP2661266B1 (en) 2011-01-07 2020-09-16 Anji Pharma (US) LLC Chemosensory receptor ligand-based therapies
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
KR20190120430A (ko) 2012-01-06 2019-10-23 엘셀릭스 테라퓨틱스 인코포레이티드 바이구아나이드 조성물 및 대사 장애를 치료하는 방법
EP2800562A2 (en) 2012-01-06 2014-11-12 Elcelyx Therapeutics, Inc. Compositions and methods for treating metabolic disorders
HK1210825A1 (en) 2012-07-11 2016-05-06 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
CN105101956B (zh) 2013-01-05 2018-12-07 埃尔舍利克斯治疗公司 包含双胍的延迟释放组合物
EP2983507B1 (en) 2013-03-15 2020-04-22 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
WO2014183041A1 (en) 2013-05-10 2014-11-13 Pepsico, Inc. Taste receptor internalization assay
JP6755640B2 (ja) 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
WO2017066799A1 (en) * 2015-10-16 2017-04-20 Cornell University Sweeteners having enhanced organoleptic properties
JP6924590B2 (ja) * 2016-03-14 2021-08-25 サントリーホールディングス株式会社 苦味評価のための融合タンパク質および苦味評価方法
WO2025183058A1 (ja) * 2024-02-29 2025-09-04 味の素株式会社 植物由来タンパク質含有食品における異味・異風味をマスキングする物質のスクリーニング方法および異味・異風味のマスキング用の組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817759A (en) * 1992-04-09 1998-10-06 Linguagen Corporation Gustducin polypeptides and fragments
EP1214343A2 (en) 1999-09-10 2002-06-19 The Regents Of The University Of California T2r taste receptor family
US6462178B1 (en) * 1999-11-17 2002-10-08 Yong Hou Wong G protein
WO2002036622A2 (en) 2000-10-30 2002-05-10 Senomyx, Inc. GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS
US7041457B2 (en) * 2000-10-30 2006-05-09 Senomyx, Inc. Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
AU2003286069A1 (en) * 2002-12-18 2004-07-09 Givaudan Sa Chimeric alpha q-gustducin g-proteins

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105339384A (zh) * 2013-05-10 2016-02-17 百事可乐公司 作为鉴别潜在味觉调节剂的模型的细胞
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
CN119193656A (zh) * 2024-09-24 2024-12-27 上海交通大学 一种响应鲜味信号的酵母细胞模型及其制备方法与应用

Also Published As

Publication number Publication date
AU2003286069A1 (en) 2004-07-09
EP1581555B1 (en) 2008-04-30
ES2305536T3 (es) 2008-11-01
US8609362B2 (en) 2013-12-17
DE60320682T2 (de) 2009-06-10
CA2507387A1 (en) 2004-07-01
JP5425651B2 (ja) 2014-02-26
US20110177545A1 (en) 2011-07-21
WO2004055048A3 (en) 2004-09-16
WO2004055048A2 (en) 2004-07-01
JP4654038B2 (ja) 2011-03-16
JP2006524483A (ja) 2006-11-02
EP1581555A2 (en) 2005-10-05
JP2010187666A (ja) 2010-09-02
DE60320682D1 (de) 2008-06-12
AU2003286069A8 (en) 2004-07-09
ATE393778T1 (de) 2008-05-15
US7919236B2 (en) 2011-04-05
US20060275765A1 (en) 2006-12-07

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