CN1714153A - 重组蛋白质变异体 - Google Patents

重组蛋白质变异体 Download PDF

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Publication number
CN1714153A
CN1714153A CNA2003801039329A CN200380103932A CN1714153A CN 1714153 A CN1714153 A CN 1714153A CN A2003801039329 A CNA2003801039329 A CN A2003801039329A CN 200380103932 A CN200380103932 A CN 200380103932A CN 1714153 A CN1714153 A CN 1714153A
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China
Prior art keywords
protein
protein variant
allergen
naturally occurring
mutations
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Pending
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CNA2003801039329A
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English (en)
Chinese (zh)
Inventor
J·霍尔姆
J·N·拉森
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ALK Abello AS
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ALK Abello AS
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Application filed by ALK Abello AS filed Critical ALK Abello AS
Publication of CN1714153A publication Critical patent/CN1714153A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43568—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from wasps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2003801039329A 2002-11-01 2003-10-31 重组蛋白质变异体 Pending CN1714153A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201686 2002-11-01
DKPA200201686 2002-11-01
US60/422,983 2002-11-01

Publications (1)

Publication Number Publication Date
CN1714153A true CN1714153A (zh) 2005-12-28

Family

ID=35719237

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801039329A Pending CN1714153A (zh) 2002-11-01 2003-10-31 重组蛋白质变异体

Country Status (8)

Country Link
US (2) US7384635B2 (https=)
EP (1) EP2270164A3 (https=)
JP (1) JP2006520184A (https=)
CN (1) CN1714153A (https=)
AU (1) AU2003275941A1 (https=)
CA (1) CA2503886A1 (https=)
PL (1) PL375218A1 (https=)
WO (1) WO2004039834A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103874509A (zh) * 2011-08-03 2014-06-18 洛法玛有限公司 来自苹果的主要变应原Mal d 1的低变应原性变体

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070665A2 (en) * 2001-03-02 2002-09-12 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
AT501101B1 (de) * 2004-12-02 2008-01-15 Biomay Ag Protein-allergen-derivat
ZA200707413B (en) 2005-03-18 2009-01-28 Cytos Biotechnology Ag Cat allergen fusion proteins and uses thereof
HUE029021T2 (en) 2005-06-21 2017-02-28 Xoma (Us) Llc IL-1beta-binding antibodies and fragments thereof
WO2008010837A2 (en) * 2005-12-15 2008-01-24 The Regents Of The University Of California Noncompetitive immunoassays to detect small molecules
EP3124045A3 (en) 2006-12-20 2017-05-03 Xoma (Us) Llc Treatment of il-1 beta related diseases
EP2028188A1 (en) * 2007-08-21 2009-02-25 Biomay AG Hypoallergenic molecules
SI2391650T1 (sl) 2007-12-20 2015-03-31 Xoma (Us) Llc Postopki za zdravljenje protina
WO2013096516A1 (en) 2011-12-19 2013-06-27 Xoma Technology Ltd. Methods for treating acne
RU2597782C1 (ru) * 2015-08-25 2016-09-20 Василий Николаевич Яковлев Способ определения содержания продуктов протеолиза в плазме крови и диагностическая тест-система для его осуществления
WO2021097174A1 (en) * 2019-11-13 2021-05-20 The Regents Of The University Of Michigan Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation
WO2021178572A1 (en) * 2020-03-03 2021-09-10 The Regents Of The University Of California Non-invasive detection of salivary autoantibodies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401180B (de) * 1990-08-13 1996-07-25 Biomay Biotech Prod Für das baumpollenallergen p14 codierende rekombinante dna-moleküle, daraus hergestellte und abgeleitete polypeptide und deren verwendung
JP3316535B2 (ja) * 1995-03-28 2002-08-19 アサヒビール株式会社 ダニアレルゲンの改変体およびその製造法
DE19810906A1 (de) 1998-03-13 1999-09-16 Basf Ag Reaktivfarbstoffe mit einem Kombinationsanker
PL194804B1 (pl) * 1998-03-16 2007-07-31 Alk Abello As Zrekombinowany alergen, sposób przygotowywania zrekombinowanego alergenu, kompozycja farmaceutyczna oraz zastosowanie zrekombinowanego alergenu do przygotowywania leku do wywoływania odpowiedzi immunologicznej u osobnika i do przygotowywania leku do leczenia, zapobiegania lub osłabiania reakcji alergicznych
ATE414773T1 (de) 2000-11-16 2008-12-15 Alk Abello As Mutante allergene
WO2002070665A2 (en) * 2001-03-02 2002-09-12 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
US7290199B2 (en) * 2004-11-19 2007-10-30 International Business Machines Corporation Method and system for improved buffer utilization for disk array parity updates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103874509A (zh) * 2011-08-03 2014-06-18 洛法玛有限公司 来自苹果的主要变应原Mal d 1的低变应原性变体
CN103874509B (zh) * 2011-08-03 2016-08-17 洛法玛有限公司 来自苹果的主要变应原Mal d 1的低变应原性变体

Also Published As

Publication number Publication date
US20090054625A1 (en) 2009-02-26
US7384635B2 (en) 2008-06-10
EP2270164A3 (en) 2011-05-04
JP2006520184A (ja) 2006-09-07
CA2503886A1 (en) 2004-05-13
US20040171116A1 (en) 2004-09-02
EP2270164A2 (en) 2011-01-05
WO2004039834A2 (en) 2004-05-13
PL375218A1 (en) 2005-11-28
WO2004039834A3 (en) 2004-08-26
AU2003275941A1 (en) 2004-05-25

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