CN1662487A - 酰胺连接基过氧化物酶体增殖物激活受体调节剂 - Google Patents

酰胺连接基过氧化物酶体增殖物激活受体调节剂 Download PDF

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CN1662487A
CN1662487A CN038141736A CN03814173A CN1662487A CN 1662487 A CN1662487 A CN 1662487A CN 038141736 A CN038141736 A CN 038141736A CN 03814173 A CN03814173 A CN 03814173A CN 1662487 A CN1662487 A CN 1662487A
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phenyl
ethoxy
alkyl
propionic acid
aryl
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Chinese (zh)
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R·费尔里托克雷斯波
J·A·马丁
F·M·D·马丁－奥尔特加
I·罗霍加西亚
Q·沈
A·M·瓦肖斯基
Y·徐
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Eli Lilly and Co
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CN038141736A 2002-06-19 2003-06-11 酰胺连接基过氧化物酶体增殖物激活受体调节剂 Pending CN1662487A (zh)

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GB0229931D0 (en) * 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
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JP2007516267A (ja) * 2003-12-15 2007-06-21 イーライ リリー アンド カンパニー 選択的ペルオキシソーム増殖因子活性化受容体モジュレータ
GB0405033D0 (en) * 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
US8071624B2 (en) 2004-06-24 2011-12-06 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
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GT200500375A (es) * 2004-12-20 2006-11-28 Derivados de piperidina y su uso como agentes antiinflamatorios
EP1893583B1 (en) 2005-05-31 2012-04-04 Pfizer Inc. Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists
US8097610B2 (en) * 2005-08-26 2012-01-17 Shionogi & Co., Ltd. Derivative having PPAR agonistic activity
JP2008239616A (ja) * 2007-02-28 2008-10-09 Iyaku Bunshi Sekkei Kenkyusho:Kk Ｈｄｌ上昇剤
CN107382980B (zh) * 2016-05-14 2020-05-15 湖南大学 N-[(二氢苯并呋喃-7-氧基)烷基]-2-芳氧基酰胺衍生物
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Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3889545T2 (de) 1987-10-20 1994-10-13 Otsuka Pharma Co Ltd Phenylcarbonsäure-abkömmlinge.
US5122539A (en) 1990-02-12 1992-06-16 Center For Innovative Technology Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood
GB9027023D0 (en) 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
JP3144624B2 (ja) 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
AU721452B2 (en) 1996-02-02 2000-07-06 Merck & Co., Inc. Antidiabetic agents
EP1019364B1 (en) 1997-08-28 2004-06-09 Biovitrum Ab Inhibitors of protein tyrosine phosphatase
AU3958200A (en) * 1999-04-20 2000-11-02 Novo Nordisk A/S New compounds, their preparation and use
US6417212B1 (en) 1999-08-27 2002-07-09 Eli Lilly & Company Modulators of peroxisome proliferator activated receptors
PE20011010A1 (es) 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP2001261612A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬
EP1310494B1 (en) 2000-08-11 2012-01-25 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
UA82048C2 (uk) 2000-11-10 2008-03-11 Эли Лилли Энд Компани Агоністи альфа-рецепторів, активованих проліфератором пероксисом
GB0113232D0 (en) 2001-05-31 2001-07-25 Glaxo Group Ltd Chemical process
CN1582279A (zh) 2001-11-30 2005-02-16 伊莱利利公司 过氧化物酶体激活的受体激动剂
SE0104334D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
DE60327922D1 (de) 2002-02-05 2009-07-23 Lilly Co Eli Harnstoff-linker verbindungen und ihre verwendung als ppar regulatoren

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