CA2488972A1 - Amide linker peroxisome proliferator activated receptor modulators - Google Patents

Amide linker peroxisome proliferator activated receptor modulators Download PDF

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Publication number
CA2488972A1
CA2488972A1 CA002488972A CA2488972A CA2488972A1 CA 2488972 A1 CA2488972 A1 CA 2488972A1 CA 002488972 A CA002488972 A CA 002488972A CA 2488972 A CA2488972 A CA 2488972A CA 2488972 A1 CA2488972 A1 CA 2488972A1
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Prior art keywords
phenyl
ethoxy
propionic acid
alkyl
ethylcarbamoyl
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Abandoned
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CA002488972A
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English (en)
French (fr)
Inventor
Rafael Ferritto Crespo
Jose Alfredo Martin
Finger Maria Dolores Martin-Ortega
Isabel Rojo Garcia
Quanrong Shen
Alan M. Warshawsky
Yanping Xu
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Eli Lilly and Co
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Individual
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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GB0229931D0 (en) * 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
SE0104334D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
GB0314079D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
JP2007516267A (ja) * 2003-12-15 2007-06-21 イーライ リリー アンド カンパニー 選択的ペルオキシソーム増殖因子活性化受容体モジュレータ
GB0405033D0 (en) * 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
US8071624B2 (en) 2004-06-24 2011-12-06 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
CA2584502A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation 2-methylpropanamides and their use as pharmaceuticals
GT200500375A (es) * 2004-12-20 2006-11-28 Derivados de piperidina y su uso como agentes antiinflamatorios
EP1893583B1 (en) 2005-05-31 2012-04-04 Pfizer Inc. Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists
US8097610B2 (en) * 2005-08-26 2012-01-17 Shionogi & Co., Ltd. Derivative having PPAR agonistic activity
JP2008239616A (ja) * 2007-02-28 2008-10-09 Iyaku Bunshi Sekkei Kenkyusho:Kk Ｈｄｌ上昇剤
CN107382980B (zh) * 2016-05-14 2020-05-15 湖南大学 N-[(二氢苯并呋喃-7-氧基)烷基]-2-芳氧基酰胺衍生物
EP3689324B1 (de) * 2019-02-04 2024-11-20 Symrise AG Neue kühlstoffe und zubereitungen, die diese enthalten

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3889545T2 (de) 1987-10-20 1994-10-13 Otsuka Pharma Co Ltd Phenylcarbonsäure-abkömmlinge.
US5122539A (en) 1990-02-12 1992-06-16 Center For Innovative Technology Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood
GB9027023D0 (en) 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
JP3144624B2 (ja) 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
AU721452B2 (en) 1996-02-02 2000-07-06 Merck & Co., Inc. Antidiabetic agents
EP1019364B1 (en) 1997-08-28 2004-06-09 Biovitrum Ab Inhibitors of protein tyrosine phosphatase
AU3958200A (en) * 1999-04-20 2000-11-02 Novo Nordisk A/S New compounds, their preparation and use
US6417212B1 (en) 1999-08-27 2002-07-09 Eli Lilly & Company Modulators of peroxisome proliferator activated receptors
PE20011010A1 (es) 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP2001261612A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬
EP1310494B1 (en) 2000-08-11 2012-01-25 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
UA82048C2 (uk) 2000-11-10 2008-03-11 Эли Лилли Энд Компани Агоністи альфа-рецепторів, активованих проліфератором пероксисом
GB0113232D0 (en) 2001-05-31 2001-07-25 Glaxo Group Ltd Chemical process
CN1582279A (zh) 2001-11-30 2005-02-16 伊莱利利公司 过氧化物酶体激活的受体激动剂
SE0104334D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
DE60327922D1 (de) 2002-02-05 2009-07-23 Lilly Co Eli Harnstoff-linker verbindungen und ihre verwendung als ppar regulatoren

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AU2003241579B2 (en) 2009-03-19
WO2004000789A1 (en) 2003-12-31
US7220880B2 (en) 2007-05-22
AU2003241579A1 (en) 2004-01-06
TW200406371A (en) 2004-05-01
MXPA04013000A (es) 2005-09-12
EP1517882A1 (en) 2005-03-30
AU2003241579B9 (en) 2009-07-30
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