CN1635998A - 三环止痛药 - Google Patents

三环止痛药 Download PDF

Info

Publication number
CN1635998A
CN1635998A CNA008086427A CN00808642A CN1635998A CN 1635998 A CN1635998 A CN 1635998A CN A008086427 A CNA008086427 A CN A008086427A CN 00808642 A CN00808642 A CN 00808642A CN 1635998 A CN1635998 A CN 1635998A
Authority
CN
China
Prior art keywords
piperidines
naphthalene
dihydro
spiral shell
oxo spiral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA008086427A
Other languages
English (en)
Chinese (zh)
Inventor
A·卡尔维特
H·雅克柏利
J·普奥德
F·J·罗曼
J·哈蒙
A·格鲁海尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of CN1635998A publication Critical patent/CN1635998A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA008086427A 1999-06-07 2000-06-07 三环止痛药 Pending CN1635998A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13786899P 1999-06-07 1999-06-07
US60/137,868 1999-06-07

Publications (1)

Publication Number Publication Date
CN1635998A true CN1635998A (zh) 2005-07-06

Family

ID=22479397

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA008086427A Pending CN1635998A (zh) 1999-06-07 2000-06-07 三环止痛药

Country Status (21)

Country Link
EP (1) EP1235808A2 (no)
JP (1) JP2003513006A (no)
KR (1) KR20020010923A (no)
CN (1) CN1635998A (no)
AP (1) AP2001002356A0 (no)
AU (1) AU6428400A (no)
BG (1) BG106162A (no)
BR (1) BR0011427A (no)
CA (1) CA2376076A1 (no)
EA (1) EA200101117A1 (no)
HR (1) HRP20010913A2 (no)
HU (1) HUP0203317A2 (no)
IL (1) IL146755A0 (no)
IS (1) IS6175A (no)
MA (1) MA26795A1 (no)
MX (1) MXPA01012694A (no)
NO (1) NO20015966L (no)
PL (1) PL357340A1 (no)
SK (1) SK17512001A3 (no)
TR (1) TR200103531T2 (no)
WO (1) WO2000075116A2 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103403004A (zh) * 2011-02-02 2013-11-20 沃泰克斯药物股份有限公司 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
FR2915099B1 (fr) * 2007-04-19 2009-06-05 Sanofi Aventis Sa Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens
GB201416346D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
CN115872873A (zh) * 2022-12-29 2023-03-31 上海泰坦科技股份有限公司 一种双（2-溴乙基）胺氢溴酸盐的重结晶纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917069D0 (en) * 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DK0681571T3 (da) * 1993-01-28 1998-11-23 Merck & Co Inc Spiro-substituerede azacykliske forbindelser som tachykininreceptorantagonister
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
WO1998025604A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103403004A (zh) * 2011-02-02 2013-11-20 沃泰克斯药物股份有限公司 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺
CN103403004B (zh) * 2011-02-02 2016-06-01 沃泰克斯药物股份有限公司 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺
CN106008504A (zh) * 2011-02-02 2016-10-12 沃泰克斯药物股份有限公司 作为离子通道调节剂的吡咯并吡嗪-螺环哌啶酰胺

Also Published As

Publication number Publication date
IS6175A (is) 2001-11-23
WO2000075116A2 (en) 2000-12-14
MA26795A1 (fr) 2004-12-20
CA2376076A1 (en) 2000-12-14
HRP20010913A2 (en) 2003-04-30
AU6428400A (en) 2000-12-28
AP2001002356A0 (en) 2001-12-31
MXPA01012694A (es) 2003-10-15
HUP0203317A2 (hu) 2003-02-28
NO20015966D0 (no) 2001-12-06
NO20015966L (no) 2001-12-06
TR200103531T2 (tr) 2002-06-21
BR0011427A (pt) 2002-03-26
JP2003513006A (ja) 2003-04-08
EA200101117A1 (ru) 2002-06-27
KR20020010923A (ko) 2002-02-06
BG106162A (bg) 2002-05-31
SK17512001A3 (sk) 2002-11-06
WO2000075116A3 (en) 2002-07-04
PL357340A1 (en) 2004-07-26
EP1235808A2 (en) 2002-09-04
IL146755A0 (en) 2002-07-25

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication