WO2000075116A3 - Tricyclic analgesics - Google Patents

Tricyclic analgesics Download PDF

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Publication number
WO2000075116A3
WO2000075116A3 PCT/EP2000/005783 EP0005783W WO0075116A3 WO 2000075116 A3 WO2000075116 A3 WO 2000075116A3 EP 0005783 W EP0005783 W EP 0005783W WO 0075116 A3 WO0075116 A3 WO 0075116A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
hydrogen
cycloalkyl
alkenyl
tricyclic
Prior art date
Application number
PCT/EP2000/005783
Other languages
French (fr)
Other versions
WO2000075116A2 (en
Inventor
Alain Calvet
Henri Jacobelli
Jocelyne Puaud
Francois J Roman
Jacques Hamon
Agnes Grouhel
Original Assignee
Warner Lambert Co
Alain Calvet
Henri Jacobelli
Jocelyne Puaud
Francois J Roman
Jacques Hamon
Agnes Grouhel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL00357340A priority Critical patent/PL357340A1/en
Priority to SK1751-2001A priority patent/SK17512001A3/en
Priority to MXPA01012694A priority patent/MXPA01012694A/en
Priority to EP00951290A priority patent/EP1235808A2/en
Priority to APAP/P/2001/002356A priority patent/AP2001002356A0/en
Priority to EA200101117A priority patent/EA200101117A1/en
Priority to IL14675500A priority patent/IL146755A0/en
Application filed by Warner Lambert Co, Alain Calvet, Henri Jacobelli, Jocelyne Puaud, Francois J Roman, Jacques Hamon, Agnes Grouhel filed Critical Warner Lambert Co
Priority to BR0011427-8A priority patent/BR0011427A/en
Priority to CA002376076A priority patent/CA2376076A1/en
Priority to KR1020017015730A priority patent/KR20020010923A/en
Priority to HU0203317A priority patent/HUP0203317A2/en
Priority to AU64284/00A priority patent/AU6428400A/en
Priority to JP2001501597A priority patent/JP2003513006A/en
Publication of WO2000075116A2 publication Critical patent/WO2000075116A2/en
Priority to IS6175A priority patent/IS6175A/en
Priority to BG106162A priority patent/BG106162A/en
Priority to NO20015966A priority patent/NO20015966L/en
Priority to HR20010913A priority patent/HRP20010913A2/en
Publication of WO2000075116A3 publication Critical patent/WO2000075116A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A tricyclic compound of Formula (I): wherein: R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; or R?1 and R2¿ together are oxygen; A is a bond, CH¿2?, CH CH3, CH2 CH2 or C(CH3)2; R?3 and R4¿ are the same or different and are hydrogen, halo, C¿1?-C6 alkyl, C1-C4 alkoxy, trifluoromethyl, NO2, COR?6, COOR6 or NR6R7¿, wherein R?6 and R7¿ are the same or different and are hydrogen, C¿1?-C6 alkyl or benzyl; R?5¿ is hydrogen, C¿1-6? alkyl, C2-6 alkenyl, C3-6 cycloalkyl, (O=C)-C1-6 alkyl, (O=C)-C2-6 alkenyl, (O=C)-C3-6 cycloalkyl, wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C3-C6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.
PCT/EP2000/005783 1999-06-07 2000-06-07 Tricyclic analgesics WO2000075116A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
JP2001501597A JP2003513006A (en) 1999-06-07 2000-06-07 Tricyclic analgesics
MXPA01012694A MXPA01012694A (en) 1999-06-07 2000-06-07 Tricyclic analgesics.
EP00951290A EP1235808A2 (en) 1999-06-07 2000-06-07 Tricyclic analgesics
APAP/P/2001/002356A AP2001002356A0 (en) 1999-06-07 2000-06-07 Tricyclic analgesics.
EA200101117A EA200101117A1 (en) 1999-06-07 2000-06-07 TRICYCLIC ANALGETICS
IL14675500A IL146755A0 (en) 1999-06-07 2000-06-07 Tricyclic analgesics
KR1020017015730A KR20020010923A (en) 1999-06-07 2000-06-07 Tricyclic Analgesics
BR0011427-8A BR0011427A (en) 1999-06-07 2000-06-07 Tricyclic painkillers
CA002376076A CA2376076A1 (en) 1999-06-07 2000-06-07 Tricyclic analgesics
PL00357340A PL357340A1 (en) 1999-06-07 2000-06-07 Tricyclic analgesics
HU0203317A HUP0203317A2 (en) 1999-06-07 2000-06-07 Tricyclic analgesics, pharmaceutical compositions containing them and their use
AU64284/00A AU6428400A (en) 1999-06-07 2000-06-07 Tricyclic analgesics
SK1751-2001A SK17512001A3 (en) 1999-06-07 2000-06-07 Tricyclic analgesics
IS6175A IS6175A (en) 1999-06-07 2001-11-23 Tricyclic painkillers
BG106162A BG106162A (en) 1999-06-07 2001-11-30 Tricyclic analgesics
NO20015966A NO20015966L (en) 1999-06-07 2001-12-06 Tricyclic analgesics
HR20010913A HRP20010913A2 (en) 1999-06-07 2001-12-07 Tricyclic analgesics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13786899P 1999-06-07 1999-06-07
US60/137,868 1999-06-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09980965 A-371-Of-International 2001-12-04
US10/896,551 Continuation US20040266802A1 (en) 1999-06-07 2004-07-22 Tricyclic analgesics

Publications (2)

Publication Number Publication Date
WO2000075116A2 WO2000075116A2 (en) 2000-12-14
WO2000075116A3 true WO2000075116A3 (en) 2002-07-04

Family

ID=22479397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/005783 WO2000075116A2 (en) 1999-06-07 2000-06-07 Tricyclic analgesics

Country Status (21)

Country Link
EP (1) EP1235808A2 (en)
JP (1) JP2003513006A (en)
KR (1) KR20020010923A (en)
CN (1) CN1635998A (en)
AP (1) AP2001002356A0 (en)
AU (1) AU6428400A (en)
BG (1) BG106162A (en)
BR (1) BR0011427A (en)
CA (1) CA2376076A1 (en)
EA (1) EA200101117A1 (en)
HR (1) HRP20010913A2 (en)
HU (1) HUP0203317A2 (en)
IL (1) IL146755A0 (en)
IS (1) IS6175A (en)
MA (1) MA26795A1 (en)
MX (1) MXPA01012694A (en)
NO (1) NO20015966L (en)
PL (1) PL357340A1 (en)
SK (1) SK17512001A3 (en)
TR (1) TR200103531T2 (en)
WO (1) WO2000075116A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
FR2915099B1 (en) * 2007-04-19 2009-06-05 Sanofi Aventis Sa USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF CRANIAL TRAUMATISM
ES2573497T3 (en) * 2011-02-02 2016-06-08 Vertex Pharmaceuticals Incorporated Spirocyclic piperidine pyrrolopyrazine-amides as ion channel modulators
CN115872873A (en) * 2022-12-29 2023-03-31 上海泰坦科技股份有限公司 Recrystallization purification method of bis (2-bromoethyl) amine hydrobromide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414289A1 (en) * 1989-07-26 1991-02-27 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
EP0431943A2 (en) * 1989-12-08 1991-06-12 Merck & Co. Inc. Nitrogen-containing spirocycles
WO1994017045A1 (en) * 1993-01-28 1994-08-04 Merck & Co., Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
WO1998025604A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414289A1 (en) * 1989-07-26 1991-02-27 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
EP0431943A2 (en) * 1989-12-08 1991-06-12 Merck & Co. Inc. Nitrogen-containing spirocycles
WO1994017045A1 (en) * 1993-01-28 1994-08-04 Merck & Co., Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
WO1998025604A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
NO20015966D0 (en) 2001-12-06
TR200103531T2 (en) 2002-06-21
IL146755A0 (en) 2002-07-25
EP1235808A2 (en) 2002-09-04
SK17512001A3 (en) 2002-11-06
AP2001002356A0 (en) 2001-12-31
EA200101117A1 (en) 2002-06-27
AU6428400A (en) 2000-12-28
IS6175A (en) 2001-11-23
CA2376076A1 (en) 2000-12-14
HUP0203317A2 (en) 2003-02-28
JP2003513006A (en) 2003-04-08
HRP20010913A2 (en) 2003-04-30
CN1635998A (en) 2005-07-06
MXPA01012694A (en) 2003-10-15
KR20020010923A (en) 2002-02-06
MA26795A1 (en) 2004-12-20
PL357340A1 (en) 2004-07-26
BG106162A (en) 2002-05-31
BR0011427A (en) 2002-03-26
NO20015966L (en) 2001-12-06
WO2000075116A2 (en) 2000-12-14

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