EA200101117A1 - TRICYCLIC ANALGETICS - Google Patents
TRICYCLIC ANALGETICSInfo
- Publication number
- EA200101117A1 EA200101117A1 EA200101117A EA200101117A EA200101117A1 EA 200101117 A1 EA200101117 A1 EA 200101117A1 EA 200101117 A EA200101117 A EA 200101117A EA 200101117 A EA200101117 A EA 200101117A EA 200101117 A1 EA200101117 A1 EA 200101117A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrogen
- alkyl
- cycloalkyl
- chch
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Трициклическое соединение формулы (I), где Rпредставляет собой водород или гидрокси; Rпредставляет собой водород или гидрокси; или Rи Rвместе представляют собой кислород; А представляет собой связь, CH, СНСН, CHCHили С(СН); Rи Rявляются одинаковыми или разными и представляют собой водород, галогено, С-Салкил, С-Салкокси, трифторметил, NO, COR, COORили NRR, где Rи Rявляются одинаковыми или разными и представляют собой водород, С-Салкил или бензил; Rпредставляет собой водород, Cалкил, Салкенил, С-циклоалкил, (O=С)-Салкил, (O=С)-Салкенил, (O=С)-Сциклоалкил, где указанные алкильные, алкенильные и циклоалкильные группы могут быть замещены 1, 2 или 3 группами, выбранными из галогено, С-Сциклоалкила, фенила или замещенного фенила; и его соли особенно полезны для лечения, среди прочих показаний, невропатической боли и других расстройств ЦНС.The tricyclic compound of formula (I), wherein R <3> is hydrogen or hydroxy; R4 is hydrogen or hydroxy; or R and R together represent oxygen; A is a bond, CH, CHCH, CHCH or C (CH); R1 and R4 are the same or different and are hydrogen, halo, C-C1-6alkyl, C-Salkoxy, trifluoromethyl, NO, COR, COOR or NRR, where R1 and R4 are the same or different and represent hydrogen, C-C1-6 alkyl or benzyl; R 5 is hydrogen, C 1-6 alkyl, Salkenyl, C-cycloalkyl, (O = C) C 1-6 alkyl, (O = C) 1-4 alkenyl, (O = C) 3-Cycloalkyl, where the indicated alkyl, alkenyl and cycloalkyl groups may be substituted 1, 2 or 3 groups selected from halogeno, C 1 -cycloalkyl, phenyl or substituted phenyl; and its salts are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13786899P | 1999-06-07 | 1999-06-07 | |
| PCT/EP2000/005783 WO2000075116A2 (en) | 1999-06-07 | 2000-06-07 | Tricyclic analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200101117A1 true EA200101117A1 (en) | 2002-06-27 |
Family
ID=22479397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200101117A EA200101117A1 (en) | 1999-06-07 | 2000-06-07 | TRICYCLIC ANALGETICS |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1235808A2 (en) |
| JP (1) | JP2003513006A (en) |
| KR (1) | KR20020010923A (en) |
| CN (1) | CN1635998A (en) |
| AP (1) | AP2001002356A0 (en) |
| AU (1) | AU6428400A (en) |
| BG (1) | BG106162A (en) |
| BR (1) | BR0011427A (en) |
| CA (1) | CA2376076A1 (en) |
| EA (1) | EA200101117A1 (en) |
| HR (1) | HRP20010913A2 (en) |
| HU (1) | HUP0203317A2 (en) |
| IL (1) | IL146755A0 (en) |
| IS (1) | IS6175A (en) |
| MA (1) | MA26795A1 (en) |
| MX (1) | MXPA01012694A (en) |
| NO (1) | NO20015966L (en) |
| PL (1) | PL357340A1 (en) |
| SK (1) | SK17512001A3 (en) |
| TR (1) | TR200103531T2 (en) |
| WO (1) | WO2000075116A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| FR2915099B1 (en) * | 2007-04-19 | 2009-06-05 | Sanofi Aventis Sa | USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF CRANIAL TRAUMATISM |
| WO2012106499A1 (en) * | 2011-02-02 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
| GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| CN115872873A (en) * | 2022-12-29 | 2023-03-31 | 上海泰坦科技股份有限公司 | Recrystallization purification method of bis (2-bromoethyl) amine hydrobromide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8917069D0 (en) * | 1989-07-26 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| DK0681571T3 (en) * | 1993-01-28 | 1998-11-23 | Merck & Co Inc | Spiro-substituted azacyclic compounds as tachykinin receptor antagonists |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| WO1998025604A1 (en) * | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| US6013644A (en) * | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
-
2000
- 2000-06-07 IL IL14675500A patent/IL146755A0/en unknown
- 2000-06-07 CA CA002376076A patent/CA2376076A1/en not_active Abandoned
- 2000-06-07 WO PCT/EP2000/005783 patent/WO2000075116A2/en not_active Application Discontinuation
- 2000-06-07 JP JP2001501597A patent/JP2003513006A/en active Pending
- 2000-06-07 HU HU0203317A patent/HUP0203317A2/en unknown
- 2000-06-07 SK SK1751-2001A patent/SK17512001A3/en unknown
- 2000-06-07 EP EP00951290A patent/EP1235808A2/en not_active Withdrawn
- 2000-06-07 AU AU64284/00A patent/AU6428400A/en not_active Abandoned
- 2000-06-07 AP APAP/P/2001/002356A patent/AP2001002356A0/en unknown
- 2000-06-07 KR KR1020017015730A patent/KR20020010923A/en not_active Application Discontinuation
- 2000-06-07 BR BR0011427-8A patent/BR0011427A/en not_active IP Right Cessation
- 2000-06-07 PL PL00357340A patent/PL357340A1/en not_active Application Discontinuation
- 2000-06-07 MX MXPA01012694A patent/MXPA01012694A/en unknown
- 2000-06-07 CN CNA008086427A patent/CN1635998A/en active Pending
- 2000-06-07 TR TR2001/03531T patent/TR200103531T2/en unknown
- 2000-06-07 EA EA200101117A patent/EA200101117A1/en unknown
-
2001
- 2001-11-23 IS IS6175A patent/IS6175A/en unknown
- 2001-11-30 BG BG106162A patent/BG106162A/en unknown
- 2001-11-30 MA MA26431A patent/MA26795A1/en unknown
- 2001-12-06 NO NO20015966A patent/NO20015966L/en not_active Application Discontinuation
- 2001-12-07 HR HR20010913A patent/HRP20010913A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS6175A (en) | 2001-11-23 |
| WO2000075116A2 (en) | 2000-12-14 |
| MA26795A1 (en) | 2004-12-20 |
| CA2376076A1 (en) | 2000-12-14 |
| HRP20010913A2 (en) | 2003-04-30 |
| AU6428400A (en) | 2000-12-28 |
| AP2001002356A0 (en) | 2001-12-31 |
| MXPA01012694A (en) | 2003-10-15 |
| CN1635998A (en) | 2005-07-06 |
| HUP0203317A2 (en) | 2003-02-28 |
| NO20015966D0 (en) | 2001-12-06 |
| NO20015966L (en) | 2001-12-06 |
| TR200103531T2 (en) | 2002-06-21 |
| BR0011427A (en) | 2002-03-26 |
| JP2003513006A (en) | 2003-04-08 |
| KR20020010923A (en) | 2002-02-06 |
| BG106162A (en) | 2002-05-31 |
| SK17512001A3 (en) | 2002-11-06 |
| WO2000075116A3 (en) | 2002-07-04 |
| PL357340A1 (en) | 2004-07-26 |
| EP1235808A2 (en) | 2002-09-04 |
| IL146755A0 (en) | 2002-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0663912T3 (en) | Heterocyclic ether compounds to enhance cognitive function | |
| DK0887344T3 (en) | Quinolines and quinazolines useful in therapy | |
| FI974447A0 (en) | Semicarbazones with CNS activity and pharmaceutical preparations containing them | |
| DK0918776T3 (en) | Total synthesis of antitumor acylfulvenes | |
| NO883487L (en) | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE HETEROCYCLIC COMPOUNDS. | |
| NO305174B1 (en) | Heterocyclic Compounds | |
| DE69309454D1 (en) | PYRIDINE CARBOXIMIDAMIDES AND THEIR USE | |
| PT1044186E (en) | SUBSTITUTED 2-BENZYLAMINO-2-PHENYL-ACETAMIDE COMPOUND | |
| ATE161268T1 (en) | ANDROSTENONE | |
| ES2179254T3 (en) | 1-PESTICIDE POLYARILPIRAZOLES. | |
| EA200101117A1 (en) | TRICYCLIC ANALGETICS | |
| ES2010284A6 (en) | Thiourea derivatives | |
| FI962768A0 (en) | N- (2-phthalimidoethyl) substituted transpiperidine-2,5-dicarboxylates | |
| DE3779813D1 (en) | 1,4-dihydropyridinderivate. | |
| DK1049672T3 (en) | Azetidine carboxamide derivatives for the treatment of CNS disorders | |
| MY133207A (en) | Substituted benzolactam compaunds | |
| EA199800308A1 (en) | PHENYLACETIC ACIDS, METHOD OF THEIR PRODUCTION AND CONTAINING THEIR MEANS | |
| EA199800931A1 (en) | METHOD OF OBTAINING PHOSPHODYSTRASE IV INHIBITORS | |
| ATE128978T1 (en) | N,N',N'-TRISUBSTITUTED 5-BISAMINOMETHYLENE-1,3-DIOXANE-4,6-DIONE AS ACYL-COA: CHOLESTEROL-ACYL TRANSFERASE INHIBITORS. | |
| BG96022A (en) | 2-(2'METHYL-3',4'-TRI-SUBSTITUTED BENZENE)-1,3- CYCLOHEXANDIONES, METHOD OF CONTROLLING UNDESIRABLE VEGETATION AND HERBICIDE COMPOSITION USING THESE COMPOUNDS | |
| DE3778088D1 (en) | SUBSTITUTED PYRIMIDOCHINOXALINE. |