TR200103531T2 - Tricyclic analgesics - Google Patents

Tricyclic analgesics

Info

Publication number
TR200103531T2
TR200103531T2 TR2001/03531T TR200103531T TR200103531T2 TR 200103531 T2 TR200103531 T2 TR 200103531T2 TR 2001/03531 T TR2001/03531 T TR 2001/03531T TR 200103531 T TR200103531 T TR 200103531T TR 200103531 T2 TR200103531 T2 TR 200103531T2
Authority
TR
Turkey
Prior art keywords
tricyclic
analgesics
cns
discomfort
indications
Prior art date
Application number
TR2001/03531T
Other languages
Turkish (tr)
Inventor
Calvet Alain
Jacobelli Henri
Puaud Jocelyne
J. Roman Fran�Ois
Hamon Jacques
Grouhel Agn�S
Original Assignee
Warner Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Company filed Critical Warner Lambert Company
Publication of TR200103531T2 publication Critical patent/TR200103531T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bu bulus bir formül (I) trisiklik bilesimi ve bunun tuzlari ile ilgilidir. Söz konusu bilesim diger endikasyonlarin yaninda özellikle nöropatik agri ve diger CNS rahatsizliklarini tedavi etmek için kullanislidir.This invention relates to a formula (I) tricyclic compound and its salts. This combination is particularly useful for treating neuropathic pain and other CNS discomfort, among other indications.

TR2001/03531T 1999-06-07 2000-06-07 Tricyclic analgesics TR200103531T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13786899P 1999-06-07 1999-06-07

Publications (1)

Publication Number Publication Date
TR200103531T2 true TR200103531T2 (en) 2002-06-21

Family

ID=22479397

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03531T TR200103531T2 (en) 1999-06-07 2000-06-07 Tricyclic analgesics

Country Status (21)

Country Link
EP (1) EP1235808A2 (en)
JP (1) JP2003513006A (en)
KR (1) KR20020010923A (en)
CN (1) CN1635998A (en)
AP (1) AP2001002356A0 (en)
AU (1) AU6428400A (en)
BG (1) BG106162A (en)
BR (1) BR0011427A (en)
CA (1) CA2376076A1 (en)
EA (1) EA200101117A1 (en)
HR (1) HRP20010913A2 (en)
HU (1) HUP0203317A2 (en)
IL (1) IL146755A0 (en)
IS (1) IS6175A (en)
MA (1) MA26795A1 (en)
MX (1) MXPA01012694A (en)
NO (1) NO20015966L (en)
PL (1) PL357340A1 (en)
SK (1) SK17512001A3 (en)
TR (1) TR200103531T2 (en)
WO (1) WO2000075116A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
FR2915099B1 (en) * 2007-04-19 2009-06-05 Sanofi Aventis Sa USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF CRANIAL TRAUMATISM
EP2670752B1 (en) * 2011-02-02 2016-03-16 Vertex Pharmaceuticals Incorporated Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
CN115872873A (en) * 2022-12-29 2023-03-31 上海泰坦科技股份有限公司 Recrystallization purification method of bis (2-bromoethyl) amine hydrobromide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917069D0 (en) * 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2154569A1 (en) * 1993-01-28 1994-08-04 Jeffrey J. Hale Spiro-substituted azacycles as tachykinin receptor antagonists
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
AU5604998A (en) * 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
JP2003513006A (en) 2003-04-08
NO20015966D0 (en) 2001-12-06
AP2001002356A0 (en) 2001-12-31
WO2000075116A2 (en) 2000-12-14
EA200101117A1 (en) 2002-06-27
BG106162A (en) 2002-05-31
EP1235808A2 (en) 2002-09-04
PL357340A1 (en) 2004-07-26
MXPA01012694A (en) 2003-10-15
CA2376076A1 (en) 2000-12-14
WO2000075116A3 (en) 2002-07-04
HRP20010913A2 (en) 2003-04-30
CN1635998A (en) 2005-07-06
AU6428400A (en) 2000-12-28
KR20020010923A (en) 2002-02-06
IS6175A (en) 2001-11-23
NO20015966L (en) 2001-12-06
MA26795A1 (en) 2004-12-20
SK17512001A3 (en) 2002-11-06
HUP0203317A2 (en) 2003-02-28
IL146755A0 (en) 2002-07-25
BR0011427A (en) 2002-03-26

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