BR0011427A - Tricyclic painkillers - Google Patents
Tricyclic painkillersInfo
- Publication number
- BR0011427A BR0011427A BR0011427-8A BR0011427A BR0011427A BR 0011427 A BR0011427 A BR 0011427A BR 0011427 A BR0011427 A BR 0011427A BR 0011427 A BR0011427 A BR 0011427A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- alkenyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção: "ANALGéSICOS TRICìCLICOS". Um composto tricíclico de Fórmula (I): em que: R^ 1^ é hidrogênio ou hidróxi; R^ 2^ é hidrogênio ou hidróxi; ou R^ 1^ e R^ 2^ juntos são oxigênio; A é uma ligação, CH~ 2~, CHCH~ 3~, CH~ 2~CH~ 2~ ou C(CH~ 3~)~ 2~; R^ 3^ e R^ 4^ são idênticos ou diferentes e são hidrogênio, halo, C~ 1-6~ alquila, C~ 1-4~ alcóxi, triflúor metila, NO~ 2~, COR^ 6^, COOR^ 6^ ou NR^ 6^R^ 7^, em que R^ 6^ e R^ 7^ são idênticos ou diferentes e são hidrogênio, C~ 1-6~ alquila ou benzila; R^ 5^ é hidrogênio, C~ 1-6~ alquila, C~ 2-6~ alquenila, C~ 3-6~ cicloalquila, (O=C)-C~ 1-6~ alquila, (O=C)-C~ 2-6~ alquenila, (O=C)-C~ 3-6~ cicloalquila, em que os ditos grupos alquila, alquenila e cicloalquila podem estar substituídos com 1, 2 ou 3 grupos selecionados de halo, C~ 3-6~ cicloalquila, fenila ou fenila substituída, e seus sais, são particularmente úteis para tratamento entre outras indicações, de dor neuropática e outros desordens CNS.Invention Patent: "TRICYCLICAL ANALGESICS". A tricyclic compound of Formula (I): wherein: R ^ 1 ^ is hydrogen or hydroxy; R ^ 2 ^ is hydrogen or hydroxy; or R ^ 1 ^ and R ^ 2 ^ together are oxygen; A is a bond, CH ~ 2 ~, CHCH ~ 3 ~, CH ~ 2 ~ CH ~ 2 ~ or C (CH ~ 3 ~) ~ 2 ~; R ^ 3 ^ and R ^ 4 ^ are identical or different and are hydrogen, halo, C ~ 1-6 ~ alkyl, C ~ 1-4 ~ alkoxy, methyl trifluorine, NO ~ 2 ~, COR ^ 6 ^, COOR ^ 6 ^ or NR ^ 6 ^ R ^ 7 ^, where R ^ 6 ^ and R ^ 7 ^ are identical or different and are hydrogen, C ~ 1-6 ~ alkyl or benzyl; R ^ 5 ^ is hydrogen, C ~ 1-6 ~ alkyl, C ~ 2-6 ~ alkenyl, C ~ 3-6 ~ cycloalkyl, (O = C) -C ~ 1-6 ~ alkyl, (O = C) -C ~ 2-6 ~ alkenyl, (O = C) -C ~ 3-6 ~ cycloalkyl, wherein said alkyl, alkenyl and cycloalkyl groups can be replaced with 1, 2 or 3 selected halo groups, C ~ 3 -6 ~ cycloalkyl, phenyl or substituted phenyl, and their salts, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13786899P | 1999-06-07 | 1999-06-07 | |
| PCT/EP2000/005783 WO2000075116A2 (en) | 1999-06-07 | 2000-06-07 | Tricyclic analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011427A true BR0011427A (en) | 2002-03-26 |
Family
ID=22479397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011427-8A BR0011427A (en) | 1999-06-07 | 2000-06-07 | Tricyclic painkillers |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1235808A2 (en) |
| JP (1) | JP2003513006A (en) |
| KR (1) | KR20020010923A (en) |
| CN (1) | CN1635998A (en) |
| AP (1) | AP2001002356A0 (en) |
| AU (1) | AU6428400A (en) |
| BG (1) | BG106162A (en) |
| BR (1) | BR0011427A (en) |
| CA (1) | CA2376076A1 (en) |
| EA (1) | EA200101117A1 (en) |
| HR (1) | HRP20010913A2 (en) |
| HU (1) | HUP0203317A2 (en) |
| IL (1) | IL146755A0 (en) |
| IS (1) | IS6175A (en) |
| MA (1) | MA26795A1 (en) |
| MX (1) | MXPA01012694A (en) |
| NO (1) | NO20015966L (en) |
| PL (1) | PL357340A1 (en) |
| SK (1) | SK17512001A3 (en) |
| TR (1) | TR200103531T2 (en) |
| WO (1) | WO2000075116A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| FR2915099B1 (en) * | 2007-04-19 | 2009-06-05 | Sanofi Aventis Sa | USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF CRANIAL TRAUMATISM |
| WO2012106499A1 (en) * | 2011-02-02 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
| GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| CN115872873A (en) * | 2022-12-29 | 2023-03-31 | 上海泰坦科技股份有限公司 | Recrystallization purification method of bis (2-bromoethyl) amine hydrobromide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8917069D0 (en) * | 1989-07-26 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| DK0681571T3 (en) * | 1993-01-28 | 1998-11-23 | Merck & Co Inc | Spiro-substituted azacyclic compounds as tachykinin receptor antagonists |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| WO1998025604A1 (en) * | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| US6013644A (en) * | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
-
2000
- 2000-06-07 IL IL14675500A patent/IL146755A0/en unknown
- 2000-06-07 CA CA002376076A patent/CA2376076A1/en not_active Abandoned
- 2000-06-07 WO PCT/EP2000/005783 patent/WO2000075116A2/en not_active Application Discontinuation
- 2000-06-07 JP JP2001501597A patent/JP2003513006A/en active Pending
- 2000-06-07 HU HU0203317A patent/HUP0203317A2/en unknown
- 2000-06-07 SK SK1751-2001A patent/SK17512001A3/en unknown
- 2000-06-07 EP EP00951290A patent/EP1235808A2/en not_active Withdrawn
- 2000-06-07 AU AU64284/00A patent/AU6428400A/en not_active Abandoned
- 2000-06-07 AP APAP/P/2001/002356A patent/AP2001002356A0/en unknown
- 2000-06-07 KR KR1020017015730A patent/KR20020010923A/en not_active Application Discontinuation
- 2000-06-07 BR BR0011427-8A patent/BR0011427A/en not_active IP Right Cessation
- 2000-06-07 PL PL00357340A patent/PL357340A1/en not_active Application Discontinuation
- 2000-06-07 MX MXPA01012694A patent/MXPA01012694A/en unknown
- 2000-06-07 CN CNA008086427A patent/CN1635998A/en active Pending
- 2000-06-07 TR TR2001/03531T patent/TR200103531T2/en unknown
- 2000-06-07 EA EA200101117A patent/EA200101117A1/en unknown
-
2001
- 2001-11-23 IS IS6175A patent/IS6175A/en unknown
- 2001-11-30 BG BG106162A patent/BG106162A/en unknown
- 2001-11-30 MA MA26431A patent/MA26795A1/en unknown
- 2001-12-06 NO NO20015966A patent/NO20015966L/en not_active Application Discontinuation
- 2001-12-07 HR HR20010913A patent/HRP20010913A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS6175A (en) | 2001-11-23 |
| WO2000075116A2 (en) | 2000-12-14 |
| MA26795A1 (en) | 2004-12-20 |
| CA2376076A1 (en) | 2000-12-14 |
| HRP20010913A2 (en) | 2003-04-30 |
| AU6428400A (en) | 2000-12-28 |
| AP2001002356A0 (en) | 2001-12-31 |
| MXPA01012694A (en) | 2003-10-15 |
| CN1635998A (en) | 2005-07-06 |
| HUP0203317A2 (en) | 2003-02-28 |
| NO20015966D0 (en) | 2001-12-06 |
| NO20015966L (en) | 2001-12-06 |
| TR200103531T2 (en) | 2002-06-21 |
| JP2003513006A (en) | 2003-04-08 |
| EA200101117A1 (en) | 2002-06-27 |
| KR20020010923A (en) | 2002-02-06 |
| BG106162A (en) | 2002-05-31 |
| SK17512001A3 (en) | 2002-11-06 |
| WO2000075116A3 (en) | 2002-07-04 |
| PL357340A1 (en) | 2004-07-26 |
| EP1235808A2 (en) | 2002-09-04 |
| IL146755A0 (en) | 2002-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |