BR9812699A - Benzamidine derivatives - Google Patents

Benzamidine derivatives

Info

Publication number
BR9812699A
BR9812699A BR9812699-7A BR9812699A BR9812699A BR 9812699 A BR9812699 A BR 9812699A BR 9812699 A BR9812699 A BR 9812699A BR 9812699 A BR9812699 A BR 9812699A
Authority
BR
Brazil
Prior art keywords
benzamidine derivatives
benzamidine
derivatives
prophylaxis
inhibitors
Prior art date
Application number
BR9812699-7A
Other languages
Portuguese (pt)
Inventor
Dieter Dorsch
Horst Juraszyk
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9812699A publication Critical patent/BR9812699A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE BENZAMIDINA"<D>. Novos compostos de fórmula I em que X, Y, R^ 1^, R^ 2^ e R^ 3^ são como definidos na reivindicação 1 de patente, são inibidores de fator de coagulação Xa e podem ser empregados para a profilaxia e/ou terapia de distúrbios tromboembólicos.Invention Patent: <B> "BENZAMIDINE DERIVATIVES" <D>. New compounds of formula I in which X, Y, R ^ 1 ^, R ^ 2 ^ and R ^ 3 ^ are as defined in patent claim 1, are inhibitors of coagulation factor Xa and can be used for prophylaxis and / or therapy for thromboembolic disorders.

BR9812699-7A 1997-10-01 1998-09-16 Benzamidine derivatives BR9812699A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19743435A DE19743435A1 (en) 1997-10-01 1997-10-01 Benzamidine derivatives
PCT/EP1998/005898 WO1999016751A1 (en) 1997-10-01 1998-09-16 Benzamidine derivatives as factor xa inhibitors

Publications (1)

Publication Number Publication Date
BR9812699A true BR9812699A (en) 2000-08-22

Family

ID=7844313

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812699-7A BR9812699A (en) 1997-10-01 1998-09-16 Benzamidine derivatives

Country Status (19)

Country Link
US (1) US6492368B1 (en)
EP (1) EP1025086B1 (en)
JP (1) JP2001518467A (en)
KR (1) KR20010024386A (en)
CN (1) CN1272107A (en)
AR (1) AR017164A1 (en)
AT (1) ATE243681T1 (en)
AU (1) AU736080B2 (en)
BR (1) BR9812699A (en)
CA (1) CA2305568A1 (en)
DE (2) DE19743435A1 (en)
HU (1) HUP0004306A3 (en)
ID (1) ID24430A (en)
NO (1) NO20001687L (en)
PL (1) PL339173A1 (en)
RU (1) RU2194044C2 (en)
SK (1) SK282799B6 (en)
WO (1) WO1999016751A1 (en)
ZA (1) ZA988937B (en)

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EP1829535A3 (en) * 1999-10-27 2007-10-24 Tanox, Inc. Tissue factor antagonists and methods of use thereof
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DE10035927A1 (en) 2000-07-21 2002-03-07 Asta Medica Ag New heteroaryl derivatives and their use as medicines
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EP1193268A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases
EP1193256A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
EP1193267A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases
DE60144284D1 (en) 2000-11-01 2011-05-05 Millennium Pharm Inc NITROGENIC HETEROCYCLIC COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE10102322A1 (en) * 2001-01-19 2002-07-25 Merck Patent Gmbh New disubstituted and trisubstituted benzene derivatives useful as coagulation inhibitors for the treatment of thromboembolic diseases
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ATE473005T1 (en) 2002-03-13 2010-07-15 Janssen Pharmaceutica Nv HISTONE DEACETYLASE INHIBITORS
US7205304B2 (en) 2002-03-13 2007-04-17 Janssen Pharmaceutica N.V. Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
ES2543588T3 (en) 2002-12-03 2015-08-20 Pharmacyclics Llc 2- (2-Hydroxybiphenyl-3-yl) -1H-benzoimidazol-5-carboxamidine derivatives as inhibitors of factor VIIa
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
JP5118975B2 (en) 2004-12-24 2013-01-16 アストラゼネカ・アクチエボラーグ Heterocyclic compounds as CCR2B antagonists
WO2007007588A1 (en) * 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. Compound having cyclic group with planarity as core
US7825122B2 (en) * 2005-12-14 2010-11-02 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
WO2007078335A2 (en) * 2005-12-21 2007-07-12 Decode Genetics, Ehf. Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
GB0525957D0 (en) * 2005-12-21 2006-02-01 Astrazeneca Ab Methods
AU2007281911B2 (en) 2006-08-04 2014-02-06 Beth Israel Deaconess Medical Center Inhibitors of pyruvate kinase and methods of treating disease
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
ES2483898T3 (en) * 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Piperidine / Piperazine Derivatives
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ES2663517T3 (en) 2007-08-27 2018-04-13 Dart Neuroscience (Cayman) Ltd Therapeutic compounds of isoxazole
WO2009035542A2 (en) * 2007-09-07 2009-03-19 Theravance, Inc. Guanidine-containing compounds useful as muscarinic receptor antagonists
AU2008301718B2 (en) * 2007-09-21 2013-01-10 Msd K.K. 4-sulfonylpiperidine derivatives
UY31863A (en) 2008-06-05 2010-01-05 Janssen Pharmaceutica Nv DRUG COMBINATIONS UNDERSTANDING A DGAT INHIBITOR AND A PPAR AGONIST
US20100152197A1 (en) * 2008-12-15 2010-06-17 Astrazeneca Ab (4-tert-butylpiperazin-2-yl)(piperazin-1-yl)methanone-n-carboxamide derivatives
US8575185B2 (en) * 2009-02-26 2013-11-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
CA2758071C (en) 2009-04-06 2018-01-09 Agios Pharmaceuticals, Inc. Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use
EP3708169A1 (en) 2009-06-29 2020-09-16 Agios Pharmaceuticals, Inc. 2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide derivatives having an anticancer activity
CA2766873C (en) 2009-06-29 2018-08-21 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
CA2821975A1 (en) 2010-12-17 2012-06-21 Shunqi Yan N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators
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Also Published As

Publication number Publication date
NO20001687D0 (en) 2000-03-31
KR20010024386A (en) 2001-03-26
HUP0004306A3 (en) 2001-12-28
EP1025086B1 (en) 2003-06-25
SK282799B6 (en) 2002-12-03
SK4472000A3 (en) 2000-11-07
NO20001687L (en) 2000-03-31
CA2305568A1 (en) 1999-04-08
AU736080B2 (en) 2001-07-26
HUP0004306A2 (en) 2001-11-28
ZA988937B (en) 1999-03-31
AR017164A1 (en) 2001-08-22
ATE243681T1 (en) 2003-07-15
AU9540798A (en) 1999-04-23
CN1272107A (en) 2000-11-01
DE59808842D1 (en) 2003-07-31
WO1999016751A1 (en) 1999-04-08
DE19743435A1 (en) 1999-04-08
EP1025086A1 (en) 2000-08-09
ID24430A (en) 2000-07-20
RU2194044C2 (en) 2002-12-10
JP2001518467A (en) 2001-10-16
US6492368B1 (en) 2002-12-10
PL339173A1 (en) 2000-12-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O,7O,8O E 9O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.