CN1515318A - 修饰过的因子vii - Google Patents

修饰过的因子vii Download PDF

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Publication number
CN1515318A
CN1515318A CNA031066089A CN03106608A CN1515318A CN 1515318 A CN1515318 A CN 1515318A CN A031066089 A CNA031066089 A CN A031066089A CN 03106608 A CN03106608 A CN 03106608A CN 1515318 A CN1515318 A CN 1515318A
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CN
China
Prior art keywords
factor
factor vii
factor viia
degr
modified
Prior art date
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Pending
Application number
CNA031066089A
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English (en)
Chinese (zh)
Inventor
L��C������ɭ
L·C·彼特森
C·E·哈特
U·赫德内
�������ɭ
M·E·拉斯穆森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zinmogeneticus
Novo Nordisk AS
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Zinmogeneticus
Novo Nordisk AS
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Application filed by Zinmogeneticus, Novo Nordisk AS filed Critical Zinmogeneticus
Publication of CN1515318A publication Critical patent/CN1515318A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6437Coagulation factor VIIa (3.4.21.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166Streptokinase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4846Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21021Coagulation factor VIIa (3.4.21.21)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA031066089A 1996-06-07 1997-06-06 修饰过的因子vii Pending CN1515318A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/660,289 1996-06-07
US08/660,289 US5833982A (en) 1991-02-28 1996-06-07 Modified factor VII

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN97195294A Division CN1131872C (zh) 1996-06-07 1997-06-06 修饰过的因子vii

Publications (1)

Publication Number Publication Date
CN1515318A true CN1515318A (zh) 2004-07-28

Family

ID=24648892

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA031066089A Pending CN1515318A (zh) 1996-06-07 1997-06-06 修饰过的因子vii
CN97195294A Expired - Fee Related CN1131872C (zh) 1996-06-07 1997-06-06 修饰过的因子vii

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN97195294A Expired - Fee Related CN1131872C (zh) 1996-06-07 1997-06-06 修饰过的因子vii

Country Status (17)

Country Link
US (2) US5833982A (OSRAM)
EP (1) EP0910580A1 (OSRAM)
JP (1) JP2000513720A (OSRAM)
KR (1) KR20000016415A (OSRAM)
CN (2) CN1515318A (OSRAM)
AU (1) AU735012B2 (OSRAM)
BR (1) BR9709661A (OSRAM)
CA (1) CA2256761A1 (OSRAM)
CZ (1) CZ394698A3 (OSRAM)
HU (1) HUP0003077A3 (OSRAM)
IL (1) IL127099A0 (OSRAM)
NO (1) NO985668L (OSRAM)
PL (1) PL330365A1 (OSRAM)
RU (1) RU2211704C2 (OSRAM)
UA (1) UA68333C2 (OSRAM)
WO (1) WO1997047651A1 (OSRAM)
ZA (1) ZA975013B (OSRAM)

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US7812132B2 (en) * 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
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CN1131872C (zh) 2003-12-24
AU3090697A (en) 1998-01-07
JP2000513720A (ja) 2000-10-17
NO985668L (no) 1999-02-04
IL127099A0 (en) 1999-09-22
CZ394698A3 (cs) 1999-04-14
NO985668D0 (no) 1998-12-04
AU735012B2 (en) 2001-06-28
WO1997047651A1 (en) 1997-12-18
RU2211704C2 (ru) 2003-09-10
KR20000016415A (ko) 2000-03-25
PL330365A1 (en) 1999-05-10
US5833982A (en) 1998-11-10
CN1221427A (zh) 1999-06-30
UA68333C2 (en) 2004-08-16
BR9709661A (pt) 2000-04-25
CA2256761A1 (en) 1997-12-18
HUP0003077A3 (en) 2003-01-28
HUP0003077A2 (hu) 2000-12-28
EP0910580A1 (en) 1999-04-28
ZA975013B (en) 1997-12-08
US6168789B1 (en) 2001-01-02

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