JP2000513720A - 修飾された第vii因子 - Google Patents
修飾された第vii因子Info
- Publication number
- JP2000513720A JP2000513720A JP10501082A JP50108298A JP2000513720A JP 2000513720 A JP2000513720 A JP 2000513720A JP 10501082 A JP10501082 A JP 10501082A JP 50108298 A JP50108298 A JP 50108298A JP 2000513720 A JP2000513720 A JP 2000513720A
- Authority
- JP
- Japan
- Prior art keywords
- factor
- factor vii
- phe
- dansyl
- protease inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.患者における血栓形成を阻害するための方法であって、血漿第X又はIX因 子を活性化する修飾された第VII因子の能力を実質的に阻害する少なくとも1つ の修飾をその触媒中心に有する第VII因子を含んで成る治療的有効用量の組成物 を、前記患者における血栓形成に対して敏感な血管部位に局部投与することを含 んで成る方法。 2.前記修飾がセリンプロテアーゼインヒビターとVII因子との反応を含んで 成る請求の範囲第1項記載の方法。 3.前記プロテアーゼインヒビターが、有機リン化合物、スルファニルフルオ リド、ペプチドハロメチルケトン、又はアザペプチドである請求の範囲第2項記 載の方法。 4.前記プロテアーゼインヒビターが、ダンシル-Phe-Pro-Argクロロメチルケ トン、ダンシル-Glu-Gly-Argクロロメチルケトン、ダンシル-Phe-Phe-Argクロロ メチルケトン及びPhe-Phe-Argクロロメチルケトンから選択されたペプチドハロ メチルケトンである請求の範囲第3項記載の方法。 5.前記血栓形成の部位が手術、顕微手術、血管形成又は外傷に関連している 請求の範囲第1〜4のいづれか1項記載の方法。 6.患者における血管開通性を維持し、又は改良するための方法であって、血 漿第X又はIX因子を活性化する修飾された第VII因子の能力を実質的に阻害する 少なくとも1つの修飾をその触媒中心に有する第VII因子を含んで成る治療的有 効用量の組成物を、低められた開通性に対して敏感な血管部位に局部投与するこ とを含んで成る方法。 7.前記修飾がセリンプロテアーゼインヒビターと第VII因子との反応を含ん で成る請求の範囲第6項記載の方法。 8.前記プロテアーゼインヒビターが、有機リン化合物、スルファニルフルオ リド、ペプチドハロメチルケトン、又はアザペプチドである請求の範囲第7項記 載の方法。 9.前記プロテアーゼインヒビターが、ダンシル-Phe-Pro-Argクロロメチルケ トン、ダンシル-Glu-Gly-Argクロロメチルケトン、ダンシル-Phe-Phe-Argクロロ メチルケトン及びPhe-Phe-Argクロロメチルケトンから選択されたペプチドハロ メチルケトンである請求の範囲第8項記載の方法。 10.前記低められた開通性の部位が手術、顕微手術、血管形成又は外傷に関連 している請求の範囲第6〜9のいづれか1項記載の方法。 11.後−虚血性再灌流に関連する心筋損傷を妨げ又は最小にするための組成物 の製造のためへの、血漿第X又はIX因子を活性化する修飾された第VII因子の能 力を実質的に阻害する少なくとも1つの修飾をその触媒中心に有する第VII因子 の使用。 12.前記修飾がセリンプロテアーゼインヒビターと第VII因子との反応を含ん で成る請求の範囲第16項記載の使用。 13.前記プロテアーゼインヒビターが、有機リン化合物、スルファニルフルオ リド、ペプチドハロメチルケトン、又はアザペプチドである請求の範囲第17項記 載の使用。 14.前記プロテアーゼインヒビターが、ダンシル-Phe-Pro-Argクロロメチルケ トン、ダンシル-Glu-Gly-Argクロロメチルケトン、ダンシル-Phe-Phe-Argクロロ メチルケトン及びPhe-Phe-Argクロロメチルケトンから選択されたペプチドハロ メチルケトンである請求の範囲第18項記載の使用。 15.前記心筋損傷が、心筋壊死である請求の範囲第16〜19のいづれか1項記載 の使用。 16.個人における後−虚血性再灌流に関連する心筋損傷を妨げ又は最小にする ための方法であって、血漿第X又はIX因子を活性化する修飾された第VII因子の 能力を実質的に阻害する少なくとも1つの修飾をその触媒中心に有する薬理学的 に許容できる第VII因子を含んで成る組成物を前記個人に投与することを含んで 成る方法。 17.前記修飾がセリンプロテアーゼインヒビターと第VII因子との反応を含ん で成る請求の範囲第21項記載の方法。 18.前記プロテアーゼインヒビターが、有機リン化合物、スルファニルフルオ リド、ペプチドハロメチルケトン、又はアザペプチドである請求の範囲第22項記 載の方法。 19.前記プロテアーゼインヒビターが、ダンシル-Phe-Pro-Argクロロメチルケ トン、ダンシル-Glu-Gly-Argクロロメチルケトン、ダンシル-Phe-Phe-Argクロロ メチルケトン及びPhe-Phe-Argクロロメチルケトンから選択されたペプチドハロ メチルケトンである請求の範囲第23項記載の方法。 20.前記心筋損傷が心筋壊死である請求の範囲第21〜24のいづれか1項記載の 方法。 21.後−虚血性再灌流の間、局部心筋血流を改良するための組成物の製造のた めへの、血漿第X又はIX因子を活性化する修飾された第VII因子の能力を実質的 に阻害する少なくとも1つの修飾をその触媒中心に有する第VII因子の使用。 22.前記修飾がセリンプロテアーゼインヒビターと第VII因子との反応を含ん で成る請求の範囲第26項記載の使用。 23.前記プロテアーゼインヒビターが、有機リン化合物、スルファニルフルオ リド、ペプチドハロメチルケトン、又はアザペプチドである請求の範囲第27項記 載の使用。 24.前記プロテアーゼインヒビターが、ダンシル-Phe-Pro-Argク ロロメチルケトン、ダンシル-Glu-Gly-Argクロロメチルケトン、ダンシル-Phe-P he-Argクロロメチルケトン及びPhe-Phe-Argクロロメチルケトンから選択された ペプチドハロメチルケトンである請求の範囲第28項記載の使用。 25.個人における後−虚血性再灌流の間、局部心筋血流を改良するための方法 であって、血漿第X又はIX因子を活性化する修飾された第VII因子の能力を実質 的に阻害する少なくとも1つの修飾をその触媒中心に有する薬理学的に許容でき る第VII因子を含んで成る組成物を前記個人に投与することを含んで成る方法。 26.前記修飾がセリンプロテアーゼインヒビターと第VII因子との反応を含ん で成る請求の範囲第30項記載の方法。 27.前記プロテアーゼインヒビターが、有機リン化合物、スルファニルフルオ リド、ペプチドハロメチルケトン、又はアザペプチドである請求の範囲第31項記 載の方法。 28.前記プロテアーゼインヒビターが、ダンシル-Phe-Pro-Argクロロメチルケ トン、ダンシル-Glu-Gly-Argクロロメチルケトン、ダンシル-Phe-Phe-Argクロロ メチルケトン及びPhe-Phe-Argクロロメチルケトンから選択されたペプチドハロ メチルケトンである請求の範囲第32項記載の方法。
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US08/660,289 | 1996-06-07 | ||
US08/660,289 US5833982A (en) | 1991-02-28 | 1996-06-07 | Modified factor VII |
PCT/DK1997/000251 WO1997047651A1 (en) | 1996-06-07 | 1997-06-06 | Modified factor vii |
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JP2000513720A true JP2000513720A (ja) | 2000-10-17 |
JP2000513720A5 JP2000513720A5 (ja) | 2005-03-10 |
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US (2) | US5833982A (ja) |
EP (1) | EP0910580A1 (ja) |
JP (1) | JP2000513720A (ja) |
KR (1) | KR20000016415A (ja) |
CN (2) | CN1515318A (ja) |
AU (1) | AU735012B2 (ja) |
BR (1) | BR9709661A (ja) |
CA (1) | CA2256761A1 (ja) |
CZ (1) | CZ394698A3 (ja) |
HU (1) | HUP0003077A3 (ja) |
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NO (1) | NO985668L (ja) |
PL (1) | PL330365A1 (ja) |
RU (1) | RU2211704C2 (ja) |
UA (1) | UA68333C2 (ja) |
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- 1996-06-07 US US08/660,289 patent/US5833982A/en not_active Expired - Fee Related
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- 1997-06-06 CZ CZ983946A patent/CZ394698A3/cs unknown
- 1997-06-06 KR KR1019980709998A patent/KR20000016415A/ko not_active Application Discontinuation
- 1997-06-06 CN CNA031066089A patent/CN1515318A/zh active Pending
- 1997-06-06 UA UA98126442A patent/UA68333C2/uk unknown
- 1997-06-06 PL PL97330365A patent/PL330365A1/xx unknown
- 1997-06-06 EP EP97925917A patent/EP0910580A1/en not_active Withdrawn
- 1997-06-06 BR BR9709661-0A patent/BR9709661A/pt not_active IP Right Cessation
- 1997-06-06 JP JP10501082A patent/JP2000513720A/ja not_active Ceased
- 1997-06-06 WO PCT/DK1997/000251 patent/WO1997047651A1/en not_active Application Discontinuation
- 1997-06-06 HU HU0003077A patent/HUP0003077A3/hu unknown
- 1997-06-06 AU AU30906/97A patent/AU735012B2/en not_active Ceased
- 1997-06-06 CN CN97195294A patent/CN1131872C/zh not_active Expired - Fee Related
- 1997-06-06 IL IL12709997A patent/IL127099A0/xx unknown
- 1997-06-06 ZA ZA9705013A patent/ZA975013B/xx unknown
- 1997-06-06 CA CA002256761A patent/CA2256761A1/en not_active Abandoned
- 1997-06-06 RU RU99100089/14A patent/RU2211704C2/ru not_active IP Right Cessation
-
1998
- 1998-11-10 US US09/189,607 patent/US6168789B1/en not_active Expired - Fee Related
- 1998-12-04 NO NO985668A patent/NO985668L/no not_active Application Discontinuation
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US8461116B2 (en) | 2001-12-21 | 2013-06-11 | Novo Nordisk Healthcare Ag | Liquid composition of factor VII polypeptides |
US8022031B2 (en) | 2001-12-21 | 2011-09-20 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
JP2005530752A (ja) * | 2002-05-03 | 2005-10-13 | ノボ ノルディスク アクティーゼルスカブ | 修飾第vii因子の安定化された固体組成物 |
US8729022B2 (en) | 2002-06-21 | 2014-05-20 | Novo Nordisk Healthcare Ag | Stabilised solid compositions of factor VII polypeptides |
US8299029B2 (en) | 2002-06-21 | 2012-10-30 | Novo Nordisk Health Care Ag | Stabilised solid compositions of factor VII polypeptides |
US8084587B2 (en) | 2003-03-26 | 2011-12-27 | Novo Nordisk Health Care Ag | Method for the production of proteins |
US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
US8536127B2 (en) | 2003-05-23 | 2013-09-17 | Novo Nordisk Healthcare Ag | Protein stabilization in solution |
US7790852B2 (en) | 2003-06-25 | 2010-09-07 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
US8026214B2 (en) | 2003-08-14 | 2011-09-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
US8318904B2 (en) | 2003-08-14 | 2012-11-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
US8658597B2 (en) | 2003-12-19 | 2014-02-25 | Novo Nordisk Healthcare Ag | Stabilised compositions of factor VII polypeptides |
JP2013056891A (ja) * | 2004-09-29 | 2013-03-28 | Novo Nordisk Health Care Ag | 陰イオン交換物質からの分画溶出によるvii因子ポリペプチドのバルクの精製 |
JP2008514677A (ja) * | 2004-09-29 | 2008-05-08 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 陰イオン交換物質からの分画溶出によるvii因子ポリペプチドのバルクの精製 |
JP2016006074A (ja) * | 2004-09-29 | 2016-01-14 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 陰イオン交換物質からの分画溶出によるvii因子ポリペプチドのバルクの精製 |
Also Published As
Publication number | Publication date |
---|---|
NO985668L (no) | 1999-02-04 |
CZ394698A3 (cs) | 1999-04-14 |
WO1997047651A1 (en) | 1997-12-18 |
RU2211704C2 (ru) | 2003-09-10 |
IL127099A0 (en) | 1999-09-22 |
CN1131872C (zh) | 2003-12-24 |
AU735012B2 (en) | 2001-06-28 |
HUP0003077A3 (en) | 2003-01-28 |
US5833982A (en) | 1998-11-10 |
ZA975013B (en) | 1997-12-08 |
CN1515318A (zh) | 2004-07-28 |
CN1221427A (zh) | 1999-06-30 |
CA2256761A1 (en) | 1997-12-18 |
HUP0003077A2 (hu) | 2000-12-28 |
PL330365A1 (en) | 1999-05-10 |
BR9709661A (pt) | 2000-04-25 |
NO985668D0 (no) | 1998-12-04 |
EP0910580A1 (en) | 1999-04-28 |
KR20000016415A (ko) | 2000-03-25 |
UA68333C2 (en) | 2004-08-16 |
AU3090697A (en) | 1998-01-07 |
US6168789B1 (en) | 2001-01-02 |
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