CN1462277A - 包含止痛肽的药物组合物 - Google Patents

包含止痛肽的药物组合物 Download PDF

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Publication number
CN1462277A
CN1462277A CN01816060A CN01816060A CN1462277A CN 1462277 A CN1462277 A CN 1462277A CN 01816060 A CN01816060 A CN 01816060A CN 01816060 A CN01816060 A CN 01816060A CN 1462277 A CN1462277 A CN 1462277A
Authority
CN
China
Prior art keywords
peptide
amino acid
trp
alkyl group
absent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01816060A
Other languages
English (en)
Chinese (zh)
Inventor
N·普里默
A·舒洛弗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
S I S SHULOV INST FOR SCIENCE
Original Assignee
Shlomite Shulovbachan
Shulov Institute for Science (SIS) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shlomite Shulovbachan, Shulov Institute for Science (SIS) Ltd filed Critical Shlomite Shulovbachan
Publication of CN1462277A publication Critical patent/CN1462277A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN01816060A 2000-08-10 2001-08-06 包含止痛肽的药物组合物 Pending CN1462277A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL137820 2000-08-10
IL137820A IL137820A (en) 2000-08-10 2000-08-10 Pharmaceutical composition for topical administration comprising an analgesic peptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011100520229A Division CN102160890B (zh) 2000-08-10 2001-08-06 包含止痛肽的药物组合物

Publications (1)

Publication Number Publication Date
CN1462277A true CN1462277A (zh) 2003-12-17

Family

ID=11074512

Family Applications (2)

Application Number Title Priority Date Filing Date
CN01816060A Pending CN1462277A (zh) 2000-08-10 2001-08-06 包含止痛肽的药物组合物
CN2011100520229A Expired - Lifetime CN102160890B (zh) 2000-08-10 2001-08-06 包含止痛肽的药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011100520229A Expired - Lifetime CN102160890B (zh) 2000-08-10 2001-08-06 包含止痛肽的药物组合物

Country Status (12)

Country Link
US (1) US7220725B2 (enExample)
EP (1) EP1309613B1 (enExample)
JP (1) JP4860096B2 (enExample)
CN (2) CN1462277A (enExample)
AT (1) ATE392428T1 (enExample)
AU (2) AU8005201A (enExample)
CA (1) CA2418793C (enExample)
DE (1) DE60133654T2 (enExample)
DK (1) DK1309613T3 (enExample)
ES (1) ES2305096T3 (enExample)
IL (1) IL137820A (enExample)
WO (1) WO2002012269A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103458912A (zh) * 2011-03-28 2013-12-18 S·I·S·舒洛弗科学创新有限公司 治疗皮肤病的方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL137820A (en) * 2000-08-10 2009-06-15 S I S Shulov Inst For Science Pharmaceutical composition for topical administration comprising an analgesic peptide
EP1865978A4 (en) * 2005-03-21 2012-01-25 Univ Columbia NEW NEURONAL PAINWAY
KR101566036B1 (ko) * 2007-03-23 2015-11-04 닛신 파마 가부시키가이샤 간질환의 예방 또는 치료용 조성물
JP5337809B2 (ja) * 2008-09-22 2013-11-06 日清ファルマ株式会社 抗炎症性ペプチド
DK2459183T3 (en) 2009-07-27 2016-01-18 Nocicepta Llc Methods for the treatment of pain
FR2948809B1 (fr) * 2009-07-31 2012-08-17 St Microelectronics Rousset Amplificateur de lecture faible puissance auto-minute
PL3242676T3 (pl) 2015-01-07 2024-07-15 Tonix Pharma Limited Preparaty oksytocyny zawierające magnez i sposoby ich stosowania
HRP20250215T1 (hr) 2016-04-12 2025-06-20 Tonix Pharma Limited Formulacije oksitocina koje sadrže magnezij i postupci upotrebe
RU2669386C1 (ru) * 2017-08-11 2018-10-11 Закрытое акционерное общество "Институт экспериментальной фармакологии" Состав и способ получения анальгетического средства пептидной структуры
BR112020019347A2 (pt) * 2018-03-29 2021-02-17 S.I.S Shulov Innovative Science Ltd. composições farmacêuticas para inibição de citocinas inflamatórias
WO2021059267A1 (en) * 2019-09-26 2021-04-01 S.I.S. Shulov Innovative Science Ltd. Compositions and methods for treating degenerative, age-related and trauma-induced disorders
US11644463B2 (en) * 2019-08-30 2023-05-09 Euroimmun Medizinische Labordiagnostika Ag Detection of an autoantibody
US12433830B2 (en) 2019-09-26 2025-10-07 S.I.S. Shulov Innovative Science Ltd. Anti-aging compositions and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491541A (en) 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
IT1172391B (it) 1983-12-23 1987-06-18 Polifarma Spa Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche
JPH0680079B2 (ja) * 1984-11-09 1994-10-12 エーザイ株式会社 ポリペプチド
IT1242002B (it) * 1990-10-03 1994-02-02 Polifarma Spa Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale
EP0668770A1 (en) 1991-04-24 1995-08-30 Warner-Lambert Company $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY
AUPM489194A0 (en) * 1994-04-07 1994-04-28 Luminis Pty Limited Peptides
RU2107691C1 (ru) * 1995-03-02 1998-03-27 Дейгин Владислав Исакович Пептид и способ его получения
US5776896A (en) * 1996-01-03 1998-07-07 Zeneca Limited Analgesic peptides from venom of grammostola spatulata and use thereof
IL127189A0 (en) * 1996-05-22 1999-09-22 Diversified Pharmaceuticals In Compositions methods and devices for the transdermal delivery of drugs
US6126939A (en) * 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
IL123001A (en) * 1998-01-20 1998-12-06 Shulov Inst For Venom Research Analgesic fraction from snake March and pharmacy preparations containing it
WO2000012553A1 (en) * 1998-08-28 2000-03-09 Myelos Corporation Cyclic prosaposin-derived peptides and uses thereof
IL137820A (en) * 2000-08-10 2009-06-15 S I S Shulov Inst For Science Pharmaceutical composition for topical administration comprising an analgesic peptide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103458912A (zh) * 2011-03-28 2013-12-18 S·I·S·舒洛弗科学创新有限公司 治疗皮肤病的方法
CN103458912B (zh) * 2011-03-28 2016-01-20 S·I·S·舒洛弗科学创新有限公司 治疗皮肤病的方法

Also Published As

Publication number Publication date
CA2418793A1 (en) 2002-02-14
CN102160890B (zh) 2013-02-06
JP4860096B2 (ja) 2012-01-25
IL137820A0 (en) 2001-10-31
AU2001280052B2 (en) 2007-11-29
AU8005201A (en) 2002-02-18
HK1160778A1 (en) 2012-08-17
EP1309613B1 (en) 2008-04-16
WO2002012269A2 (en) 2002-02-14
WO2002012269A3 (en) 2002-12-19
CA2418793C (en) 2011-11-15
CN102160890A (zh) 2011-08-24
JP2004513079A (ja) 2004-04-30
DK1309613T3 (da) 2008-08-11
ES2305096T3 (es) 2008-11-01
US20040014673A1 (en) 2004-01-22
DE60133654T2 (de) 2009-06-04
DE60133654D1 (de) 2008-05-29
IL137820A (en) 2009-06-15
EP1309613A2 (en) 2003-05-14
ATE392428T1 (de) 2008-05-15
US7220725B2 (en) 2007-05-22

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Free format text: FORMER OWNER: AMAR BALABO

Effective date: 20050701

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20050701

Address after: Rehovot

Applicant after: S. I. S. Shulov Inst For Science

Address before: Rehovot

Applicant before: S. I. S. Shulov Inst For Science

Co-applicant before: Shlomite Shulofbakan