CN1439011A - 具有磷酸二酯酶V－抑制作用的5－氨基烷基吡唑并[4,3－d]嘧啶 - Google Patents

具有磷酸二酯酶V－抑制作用的5－氨基烷基吡唑并[4,3－d]嘧啶 Download PDF

Info

Publication number
CN1439011A
CN1439011A CN01811801A CN01811801A CN1439011A CN 1439011 A CN1439011 A CN 1439011A CN 01811801 A CN01811801 A CN 01811801A CN 01811801 A CN01811801 A CN 01811801A CN 1439011 A CN1439011 A CN 1439011A
Authority
CN
China
Prior art keywords
methyl
pyrazolo
propyl
chloro
methoxybenzylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN01811801A
Other languages
English (en)
Chinese (zh)
Inventor
R·约纳斯
P·舍林
M·克里斯塔德勒
N·拜尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1439011A publication Critical patent/CN1439011A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN01811801A 2000-06-29 2001-06-28 具有磷酸二酯酶V－抑制作用的5－氨基烷基吡唑并[4,3－d]嘧啶 Pending CN1439011A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10031584.4 2000-06-29
DE10031584A DE10031584A1 (de) 2000-06-29 2000-06-29 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine

Publications (1)

Publication Number Publication Date
CN1439011A true CN1439011A (zh) 2003-08-27

Family

ID=7647151

Family Applications (1)

Application Number Title Priority Date Filing Date
CN01811801A Pending CN1439011A (zh) 2000-06-29 2001-06-28 具有磷酸二酯酶V－抑制作用的5－氨基烷基吡唑并[4,3－d]嘧啶

Country Status (21)

Country Link
US (1) US7060823B2 (enExample)
EP (1) EP1296986B1 (enExample)
JP (1) JP4964388B2 (enExample)
KR (1) KR20030017558A (enExample)
CN (1) CN1439011A (enExample)
AR (1) AR028772A1 (enExample)
AT (1) ATE519761T1 (enExample)
AU (2) AU7970001A (enExample)
BR (1) BR0111915A (enExample)
CA (1) CA2410399C (enExample)
CZ (1) CZ20024054A3 (enExample)
DE (1) DE10031584A1 (enExample)
ES (1) ES2367704T3 (enExample)
HU (1) HUP0301587A3 (enExample)
MX (1) MXPA02012263A (enExample)
NO (1) NO20026247L (enExample)
PL (1) PL358551A1 (enExample)
RU (1) RU2271359C2 (enExample)
SK (1) SK17632002A3 (enExample)
WO (1) WO2002000660A1 (enExample)
ZA (1) ZA200209728B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101362765B (zh) * 2003-11-24 2011-02-02 辉瑞有限公司 具有PDE-5抑制活性的5,7-二氨基吡唑并[4,3-d]嘧啶
CN104159899A (zh) * 2012-01-11 2014-11-19 拜耳知识产权有限责任公司 取代的三嗪衍生物及其作为可溶性鸟苷酸环化酶激发物的用途
CN104718207A (zh) * 2012-07-06 2015-06-17 制药科学公司 蛋白激酶抑制剂

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
UA80871C2 (en) * 2003-04-29 2007-11-12 Pfizer Ltd 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
JP2007532526A (ja) * 2004-04-07 2007-11-15 ファイザー・インク ピラゾロ［４，３−ｄ］ピリミジン類
JP2008517994A (ja) * 2004-10-28 2008-05-29 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 新規医薬品
US8227475B2 (en) * 2005-05-12 2012-07-24 Pfizer Inc. Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1739850A3 (ru) * 1987-08-31 1992-06-07 Такеда Кемикал Индастриз, Лтд (Фирма) Способ получени конденсированных производных пиразоло[3,4- @ ]пиримидина
US5075310A (en) 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
GB9119704D0 (en) * 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic agents
JP2657760B2 (ja) 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9423911D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE19942474A1 (de) 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101362765B (zh) * 2003-11-24 2011-02-02 辉瑞有限公司 具有PDE-5抑制活性的5,7-二氨基吡唑并[4,3-d]嘧啶
CN101362764B (zh) * 2003-11-24 2011-04-20 辉瑞有限公司 具有PDE-5抑制活性的5,7-二氨基吡唑并[4,3-d]嘧啶
CN1882591B (zh) * 2003-11-24 2011-08-10 辉瑞有限公司 具有PDE-5抑制活性的5,7-二氨基吡唑并[4,3-d]嘧啶
CN104159899A (zh) * 2012-01-11 2014-11-19 拜耳知识产权有限责任公司 取代的三嗪衍生物及其作为可溶性鸟苷酸环化酶激发物的用途
CN104159899B (zh) * 2012-01-11 2017-02-22 拜耳知识产权有限责任公司 取代的三嗪衍生物及其作为可溶性鸟苷酸环化酶激发物的用途
CN104718207A (zh) * 2012-07-06 2015-06-17 制药科学公司 蛋白激酶抑制剂

Also Published As

Publication number Publication date
PL358551A1 (en) 2004-08-09
AU7970001A (en) 2002-01-08
AU2001279700B2 (en) 2006-08-24
CA2410399A1 (en) 2002-01-03
JP2004501921A (ja) 2004-01-22
DE10031584A1 (de) 2002-01-10
ATE519761T1 (de) 2011-08-15
US20040029900A1 (en) 2004-02-12
RU2271359C2 (ru) 2006-03-10
KR20030017558A (ko) 2003-03-03
NO20026247D0 (no) 2002-12-27
AR028772A1 (es) 2003-05-21
CZ20024054A3 (cs) 2003-04-16
ZA200209728B (en) 2004-03-12
BR0111915A (pt) 2003-05-13
ES2367704T3 (es) 2011-11-07
EP1296986B1 (de) 2011-08-10
JP4964388B2 (ja) 2012-06-27
US7060823B2 (en) 2006-06-13
HUP0301587A3 (en) 2005-11-28
NO20026247L (no) 2002-12-27
EP1296986A1 (de) 2003-04-02
SK17632002A3 (sk) 2003-05-02
MXPA02012263A (es) 2003-04-25
CA2410399C (en) 2010-02-16
WO2002000660A1 (de) 2002-01-03
HUP0301587A2 (hu) 2003-09-29

Similar Documents

Publication Publication Date Title
KR100488429B1 (ko) 포스포디에스테라제 ｖ 억제효과를 가지는 티에노피리미딘
CN1439011A (zh) 具有磷酸二酯酶V－抑制作用的5－氨基烷基吡唑并[4,3－d]嘧啶
JP4314341B2 (ja) チエノピリミジン類
KR20030051867A (ko) 티에노피리미딘의 용도
JP4242561B2 (ja) ホスホジエステラーゼｖ阻害作用を有する凝縮チエノピリミジン類
JP4975921B2 (ja) ピラゾロ［４，３−ｄ］ピリミジン
JP2003502429A (ja) ホスホジエステラーゼ阻害剤としてのチエノピリミジン
CN1234712C (zh) 2－氨基烷基噻吩并[2,3－d]嘧啶
KR20030051870A (ko) 피라졸로[４,３-ｄ]피리미딘의 용도
TW202102502A (zh) 作為流感病毒複製抑制劑之稠合多環吡啶酮化合物
KR20030055338A (ko) 피라졸로[4,3-ｄ]피리미딘의 용도
HK1054943A (en) 5-aminoalkyl-pyrazolo [4,3-d] pyrimidines with a phosphodiesterase v-inhibiting effect
HK1054944A (en) 2-aminoalkyl-thieno [2,3-d] pyrimidines
KR20020026011A (ko) 티에노피리미딘의 용도
HK1024484B (en) Thienopyrimidines having pde v-inhibiting action
HK40057163A (en) Imidazoquinoline compounds and uses thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1054943

Country of ref document: HK