CN1390232A - 人β分泌酶、抑制剂、其组合物和用途 - Google Patents

人β分泌酶、抑制剂、其组合物和用途 Download PDF

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Publication number
CN1390232A
CN1390232A CN00806471A CN00806471A CN1390232A CN 1390232 A CN1390232 A CN 1390232A CN 00806471 A CN00806471 A CN 00806471A CN 00806471 A CN00806471 A CN 00806471A CN 1390232 A CN1390232 A CN 1390232A
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Prior art keywords
secretase
seq
beta
albumen
sequence
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Pending
Application number
CN00806471A
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English (en)
Chinese (zh)
Inventor
约翰·P·安德森
古里巴尔·巴西
米尼·丹·多恩
诺曼德·弗里根
瓦尔吉斯·约翰
迈克尔·鲍尔
苏坎托·辛哈
格温·塔苏诺
杰伊·廷格
王淑文
利萨·麦康恩洛格
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Elan Pharmaceuticals LLC
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Elan Pharmaceuticals LLC
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Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Publication of CN1390232A publication Critical patent/CN1390232A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN00806471A 1999-02-10 2000-02-10 人β分泌酶、抑制剂、其组合物和用途 Pending CN1390232A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11957199P 1999-02-10 1999-02-10
US60/119,571 1999-02-10
US13917299P 1999-06-15 1999-06-15
US60/139,172 1999-06-15

Publications (1)

Publication Number Publication Date
CN1390232A true CN1390232A (zh) 2003-01-08

Family

ID=26817477

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00806471A Pending CN1390232A (zh) 1999-02-10 2000-02-10 人β分泌酶、抑制剂、其组合物和用途

Country Status (10)

Country Link
US (3) US6627739B1 (https=)
EP (1) EP1165609A2 (https=)
JP (1) JP4653318B2 (https=)
CN (1) CN1390232A (https=)
AU (1) AU4000900A (https=)
CA (1) CA2359785A1 (https=)
GB (1) GB2364059B (https=)
HK (2) HK1044545A1 (https=)
NZ (1) NZ534876A (https=)
WO (1) WO2000047618A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101270359B (zh) * 2008-04-30 2012-05-23 江苏省原子医学研究所 一种重组人淀粉样蛋白Aβ42的制备方法及应用

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