CN1317299C - 生物发光提高的发光蛋白质 - Google Patents

生物发光提高的发光蛋白质 Download PDF

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Publication number
CN1317299C
CN1317299C CNB2003801017480A CN200380101748A CN1317299C CN 1317299 C CN1317299 C CN 1317299C CN B2003801017480 A CNB2003801017480 A CN B2003801017480A CN 200380101748 A CN200380101748 A CN 200380101748A CN 1317299 C CN1317299 C CN 1317299C
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CN
China
Prior art keywords
photoprotein
protein
chimeric
residues
beilin
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Expired - Fee Related
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CNB2003801017480A
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English (en)
Chinese (zh)
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CN1705680A (zh
Inventor
M·福蒂
S·洛默尔
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AXXAM Srl
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AXXAM Srl
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Publication of CN1705680A publication Critical patent/CN1705680A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Dental Preparations (AREA)
CNB2003801017480A 2002-10-21 2003-10-21 生物发光提高的发光蛋白质 Expired - Fee Related CN1317299C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02023452.2 2002-10-21
EP02023452A EP1413584B1 (en) 2002-10-21 2002-10-21 Photoprotein with improved bioluminescence

Publications (2)

Publication Number Publication Date
CN1705680A CN1705680A (zh) 2005-12-07
CN1317299C true CN1317299C (zh) 2007-05-23

Family

ID=32049982

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801017480A Expired - Fee Related CN1317299C (zh) 2002-10-21 2003-10-21 生物发光提高的发光蛋白质

Country Status (21)

Country Link
US (1) US7601805B2 (enExample)
EP (1) EP1413584B1 (enExample)
JP (1) JP4459058B2 (enExample)
KR (1) KR20050053783A (enExample)
CN (1) CN1317299C (enExample)
AT (1) ATE290016T1 (enExample)
AU (1) AU2003287962B2 (enExample)
BR (1) BR0306589A (enExample)
CA (1) CA2503145A1 (enExample)
DE (1) DE60203123T2 (enExample)
DK (1) DK1413584T3 (enExample)
ES (1) ES2237643T3 (enExample)
HR (1) HRP20050354A2 (enExample)
IL (1) IL168158A (enExample)
MX (1) MXPA05004148A (enExample)
NO (1) NO20051921L (enExample)
PL (1) PL376323A1 (enExample)
RS (1) RS54004A (enExample)
RU (1) RU2340629C2 (enExample)
WO (1) WO2004035620A1 (enExample)
ZA (1) ZA200503197B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10342670A1 (de) * 2003-09-16 2005-04-21 Bayer Healthcare Ag Isoliertes Photoprotein mtClytin, sowie dessen Verwendung
EP1700865A1 (en) * 2005-03-11 2006-09-13 AXXAM S.r.l. Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators
EP1808441A1 (en) * 2006-01-11 2007-07-18 AXXAM S.p.A. Luminescent stem cells, transgenic mammals and uses thereof
EP1973938B1 (en) * 2006-01-11 2011-04-06 Axxam S.P.A. Luminescent stem cells and uses thereof
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
EP2489745B1 (en) 2006-06-05 2017-01-11 California Institute Of Technology Real time micro arrays
JP5374840B2 (ja) 2006-07-20 2013-12-25 Ｊｎｃ株式会社 カルシウム結合発光蛋白質、それをコードする遺伝子およびその用途
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
GB0625678D0 (en) * 2006-12-21 2007-01-31 Lux Biotechnology Ltd Composition and method for detection of demineralisation
US8431698B2 (en) * 2007-08-29 2013-04-30 Biolume Inc. Bioluminescent endoscopy methods and compounds
EP2382470B1 (en) * 2009-01-29 2014-12-10 Commonwealth Scientific and Industrial Research Organisation Measuring g protein coupled receptor activation
JP5304275B2 (ja) * 2009-01-29 2013-10-02 Ｊｎｃ株式会社 アポクライティン−ｉｉをコードするコドン最適化核酸およびその使用方法
BR112013010855A2 (pt) 2010-11-02 2017-06-27 Promega Corp luciferases derivadas de oplophorus, novos substratos de coelenterazina e métodos de uso
SG189494A1 (en) * 2010-11-02 2013-05-31 Promega Corp Coelenterazine derivatives and methods of using same
EP2657336B1 (en) 2010-12-24 2018-07-04 Otsuka Pharmaceutical Co., Ltd. Bioassay method for detecting physiologically active substance
AU2013204332B2 (en) * 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
EP3099683B1 (en) 2014-01-29 2020-08-05 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
EP3099691B1 (en) 2014-01-29 2019-11-20 Promega Corporation Pro-substrates for live cell applications
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
JP2020510406A (ja) 2016-11-14 2020-04-09 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション プロテアーゼセンサー分子
GB201700317D0 (en) 2017-01-09 2017-02-22 Calcivis Ltd Detection device
PL3665481T3 (pl) 2017-08-08 2024-02-05 PPB Technology Pty Ltd Czujniki węglowodanów
WO2019241318A1 (en) * 2018-06-13 2019-12-19 Cornell University Bioluminescent markers of neural activity
JP7687957B2 (ja) 2019-03-14 2025-06-03 インシリクサ， インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
USD1042180S1 (en) 2020-05-28 2024-09-17 Calcivis Limited Dental detection device
RU2770490C1 (ru) * 2021-07-14 2022-04-18 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" Рекомбинантная плазмидная ДНК pET19b-Surv-OL, обеспечивающая синтез гибридного белка сурвивин-обелин (Surv-OL) и гибридный белок, связываемый анти-сурвивин антителами и обладающий биолюминесцентной активностью

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114175C1 (ru) * 1993-09-14 1998-06-27 Институт белка РАН Способ клонирования нуклеиновых кислот

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Obelin from the bioluminescent marine hydroid Obeliageniculata:Cloning,expression,and comparison of someproperties with those of other Ca2+-regulated photoproteins MARKOVA SVETLANA V ET A,BIOCHEMISTR,Vol.41 No.7 2002 *
Recombinant obelin:Cloning and expression of cDNA,purification, and characterization as a calcium indicator ILLARIONOV BORIS A ET A,METHODS IN ENZYMOLOG,Vol.305 2000 *

Also Published As

Publication number Publication date
RU2005111772A (ru) 2005-09-10
NO20051921L (no) 2005-05-23
AU2003287962B2 (en) 2010-06-17
AU2003287962A1 (en) 2004-05-04
PL376323A1 (en) 2005-12-27
HRP20050354B1 (enExample) 2007-01-31
ZA200503197B (en) 2006-06-28
JP4459058B2 (ja) 2010-04-28
EP1413584B1 (en) 2005-03-02
DE60203123D1 (de) 2005-04-07
CA2503145A1 (en) 2004-04-29
RU2340629C2 (ru) 2008-12-10
ES2237643T3 (es) 2005-08-01
IL168158A (en) 2010-06-16
MXPA05004148A (es) 2005-08-03
RS54004A (sr) 2006-10-27
KR20050053783A (ko) 2005-06-08
DK1413584T3 (da) 2005-07-04
BR0306589A (pt) 2004-11-30
ATE290016T1 (de) 2005-03-15
WO2004035620A1 (en) 2004-04-29
HRP20050354A2 (en) 2005-08-31
EP1413584A1 (en) 2004-04-28
CN1705680A (zh) 2005-12-07
US7601805B2 (en) 2009-10-13
US20070065818A1 (en) 2007-03-22
DE60203123T2 (de) 2005-07-21
JP2006517784A (ja) 2006-08-03

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070523

Termination date: 20121021