CN1298713C - 5－取代异苯并呋喃的制备方法 - Google Patents

5－取代异苯并呋喃的制备方法 Download PDF

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Publication number
CN1298713C
CN1298713C CNB028183231A CN02818323A CN1298713C CN 1298713 C CN1298713 C CN 1298713C CN B028183231 A CNB028183231 A CN B028183231A CN 02818323 A CN02818323 A CN 02818323A CN 1298713 C CN1298713 C CN 1298713C
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CN
China
Prior art keywords
formula
group
citalopram
trityl
alkyl
Prior art date
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Expired - Fee Related
Application number
CNB028183231A
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English (en)
Chinese (zh)
Other versions
CN1555370A (zh
Inventor
L·达尔阿斯塔
G·科提斯里
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Infosint SA
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Infosint SA
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Publication date
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Publication of CN1555370A publication Critical patent/CN1555370A/zh
Application granted granted Critical
Publication of CN1298713C publication Critical patent/CN1298713C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB028183231A 2001-08-02 2002-07-29 5－取代异苯并呋喃的制备方法 Expired - Fee Related CN1298713C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01830517A EP1281707B1 (en) 2001-08-02 2001-08-02 Process for the preparation of 5-subtituted isobenzofurans
EP01830517.7 2001-08-02

Publications (2)

Publication Number Publication Date
CN1555370A CN1555370A (zh) 2004-12-15
CN1298713C true CN1298713C (zh) 2007-02-07

Family

ID=8184643

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028183231A Expired - Fee Related CN1298713C (zh) 2001-08-02 2002-07-29 5－取代异苯并呋喃的制备方法

Country Status (22)

Country Link
US (1) US7166729B2 (https=)
EP (1) EP1281707B1 (https=)
JP (1) JP2005501056A (https=)
KR (1) KR20040043176A (https=)
CN (1) CN1298713C (https=)
AR (1) AR036212A1 (https=)
AT (1) ATE286037T1 (https=)
AU (1) AU2002325385B2 (https=)
BG (1) BG108554A (https=)
BR (1) BR0211858A (https=)
CA (1) CA2456004A1 (https=)
DE (1) DE60108105T2 (https=)
DK (1) DK1281707T3 (https=)
ES (1) ES2234797T3 (https=)
HU (1) HUP0401166A3 (https=)
MX (1) MXPA04001030A (https=)
PL (1) PL368320A1 (https=)
PT (1) PT1281707E (https=)
RO (1) RO122147B1 (https=)
TW (1) TWI225055B (https=)
WO (1) WO2003011846A2 (https=)
ZA (1) ZA200400841B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
GB0601286D0 (en) * 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
JP5583592B2 (ja) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション Ｉｄｏ阻害剤
CN106632182A (zh) * 2016-12-07 2017-05-10 万全万特制药（厦门）有限公司 草酸艾司西酞普兰脱甲基杂质的制备方法
CN113784945A (zh) * 2018-12-22 2021-12-10 马拉迪制药有限公司 制备R-苯基乙酰基甲醇和β-氨基醇的新方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0171943A1 (en) * 1984-08-06 1986-02-19 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO1999030548A2 (en) * 1999-04-14 1999-06-24 H. Lundbeck A/S Method for the preparation of citalopram
WO2001002383A2 (en) * 1999-07-06 2001-01-11 Lundbeck Pharmaceuticals Italy S.P.A. Process for the synthesis of citalopram

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0171943A1 (en) * 1984-08-06 1986-02-19 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO1999030548A2 (en) * 1999-04-14 1999-06-24 H. Lundbeck A/S Method for the preparation of citalopram
WO2001002383A2 (en) * 1999-07-06 2001-01-11 Lundbeck Pharmaceuticals Italy S.P.A. Process for the synthesis of citalopram

Also Published As

Publication number Publication date
US7166729B2 (en) 2007-01-23
EP1281707A1 (en) 2003-02-05
BR0211858A (pt) 2004-09-21
PL368320A1 (en) 2005-03-21
US20040230065A1 (en) 2004-11-18
AU2002325385B2 (en) 2007-07-05
MXPA04001030A (es) 2004-12-03
HK1070357A1 (zh) 2005-06-17
HUP0401166A2 (hu) 2004-09-28
ATE286037T1 (de) 2005-01-15
EP1281707B1 (en) 2004-12-29
ES2234797T3 (es) 2005-07-01
PT1281707E (pt) 2005-04-29
CA2456004A1 (en) 2003-02-13
TWI225055B (en) 2004-12-11
RO122147B1 (ro) 2009-01-30
KR20040043176A (ko) 2004-05-22
HUP0401166A3 (en) 2007-05-29
WO2003011846A2 (en) 2003-02-13
CN1555370A (zh) 2004-12-15
DE60108105D1 (de) 2005-02-03
WO2003011846A3 (en) 2003-11-27
WO2003011846B1 (en) 2003-12-24
BG108554A (bg) 2005-03-31
ZA200400841B (en) 2005-02-02
AU2002325385B8 (en) 2003-02-17
AR036212A1 (es) 2004-08-18
JP2005501056A (ja) 2005-01-13
DK1281707T3 (da) 2005-05-02
DE60108105T2 (de) 2005-12-08

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