BR0211858A - Processo de preparação de isobenzofuranos 5-substituìdos - Google Patents
Processo de preparação de isobenzofuranos 5-substituìdosInfo
- Publication number
- BR0211858A BR0211858A BR0211858-0A BR0211858A BR0211858A BR 0211858 A BR0211858 A BR 0211858A BR 0211858 A BR0211858 A BR 0211858A BR 0211858 A BR0211858 A BR 0211858A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- citaloprama
- isobenzofuran
- substituted
- pharmaceutically acceptable
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 5-Substituted Isobenzofurans Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- DBSGLQIKLWDTTD-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carbaldehyde Chemical compound O=CC1=CC=C2C(=O)OCC2=C1 DBSGLQIKLWDTTD-UHFFFAOYSA-N 0.000 abstract 1
- UXGVMFHEKMGWMA-UHFFFAOYSA-N 2-benzofuran Chemical compound C1=CC=CC2=COC=C21 UXGVMFHEKMGWMA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- ORWKVZNEPHTCQE-UHFFFAOYSA-N acetic formic anhydride Chemical compound CC(=O)OC=O ORWKVZNEPHTCQE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01830517A EP1281707B1 (en) | 2001-08-02 | 2001-08-02 | Process for the preparation of 5-subtituted isobenzofurans |
| PCT/EP2002/008550 WO2003011846A2 (en) | 2001-08-02 | 2002-07-29 | Process for the preparation of 5-substituted isobenzofurans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0211858A true BR0211858A (pt) | 2004-09-21 |
Family
ID=8184643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0211858-0A BR0211858A (pt) | 2001-08-02 | 2002-07-29 | Processo de preparação de isobenzofuranos 5-substituìdos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7166729B2 (https=) |
| EP (1) | EP1281707B1 (https=) |
| JP (1) | JP2005501056A (https=) |
| KR (1) | KR20040043176A (https=) |
| CN (1) | CN1298713C (https=) |
| AR (1) | AR036212A1 (https=) |
| AT (1) | ATE286037T1 (https=) |
| AU (1) | AU2002325385B2 (https=) |
| BG (1) | BG108554A (https=) |
| BR (1) | BR0211858A (https=) |
| CA (1) | CA2456004A1 (https=) |
| DE (1) | DE60108105T2 (https=) |
| DK (1) | DK1281707T3 (https=) |
| ES (1) | ES2234797T3 (https=) |
| HU (1) | HUP0401166A3 (https=) |
| MX (1) | MXPA04001030A (https=) |
| PL (1) | PL368320A1 (https=) |
| PT (1) | PT1281707E (https=) |
| RO (1) | RO122147B1 (https=) |
| TW (1) | TWI225055B (https=) |
| WO (1) | WO2003011846A2 (https=) |
| ZA (1) | ZA200400841B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| AU2003263155A1 (en) * | 2002-09-20 | 2004-04-08 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
| GB0601286D0 (en) * | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ｉｄｏ阻害剤 |
| CN106632182A (zh) * | 2016-12-07 | 2017-05-10 | 万全万特制药（厦门）有限公司 | 草酸艾司西酞普兰脱甲基杂质的制备方法 |
| CN113784945A (zh) * | 2018-12-22 | 2021-12-10 | 马拉迪制药有限公司 | 制备R-苯基乙酰基甲醇和β-氨基醇的新方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| WO1998019513A2 (en) * | 1997-07-08 | 1998-05-14 | H. Lundbeck A/S | Method for the preparation of citalopram |
| AU759716B2 (en) * | 1999-04-14 | 2003-04-17 | H. Lundbeck A/S | Method for the preparation of citalopram |
| ITMI991486A1 (it) * | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| IES20010143A2 (en) * | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
| IT1319686B1 (it) * | 2000-12-12 | 2003-10-23 | C D Farmasint S R L | Procedimento di preparazione di citalopram. |
-
2001
- 2001-08-02 DE DE60108105T patent/DE60108105T2/de not_active Expired - Fee Related
- 2001-08-02 EP EP01830517A patent/EP1281707B1/en not_active Expired - Lifetime
- 2001-08-02 DK DK01830517T patent/DK1281707T3/da active
- 2001-08-02 ES ES01830517T patent/ES2234797T3/es not_active Expired - Lifetime
- 2001-08-02 PT PT01830517T patent/PT1281707E/pt unknown
- 2001-08-02 AT AT01830517T patent/ATE286037T1/de not_active IP Right Cessation
-
2002
- 2002-07-29 MX MXPA04001030A patent/MXPA04001030A/es active IP Right Grant
- 2002-07-29 AU AU2002325385A patent/AU2002325385B2/en not_active Ceased
- 2002-07-29 CN CNB028183231A patent/CN1298713C/zh not_active Expired - Fee Related
- 2002-07-29 RO ROA200400084A patent/RO122147B1/ro unknown
- 2002-07-29 KR KR10-2004-7001616A patent/KR20040043176A/ko not_active Ceased
- 2002-07-29 CA CA002456004A patent/CA2456004A1/en not_active Abandoned
- 2002-07-29 HU HU0401166A patent/HUP0401166A3/hu unknown
- 2002-07-29 WO PCT/EP2002/008550 patent/WO2003011846A2/en not_active Ceased
- 2002-07-29 JP JP2003517038A patent/JP2005501056A/ja active Pending
- 2002-07-29 BR BR0211858-0A patent/BR0211858A/pt not_active IP Right Cessation
- 2002-07-29 PL PL02368320A patent/PL368320A1/xx not_active Application Discontinuation
- 2002-07-31 TW TW091117176A patent/TWI225055B/zh active
- 2002-08-02 AR ARP020102955A patent/AR036212A1/es unknown
-
2004
- 2004-01-30 BG BG108554A patent/BG108554A/bg unknown
- 2004-01-31 US US10/776,625 patent/US7166729B2/en not_active Expired - Fee Related
- 2004-02-02 ZA ZA200400841A patent/ZA200400841B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7166729B2 (en) | 2007-01-23 |
| EP1281707A1 (en) | 2003-02-05 |
| PL368320A1 (en) | 2005-03-21 |
| US20040230065A1 (en) | 2004-11-18 |
| AU2002325385B2 (en) | 2007-07-05 |
| MXPA04001030A (es) | 2004-12-03 |
| CN1298713C (zh) | 2007-02-07 |
| HK1070357A1 (zh) | 2005-06-17 |
| HUP0401166A2 (hu) | 2004-09-28 |
| ATE286037T1 (de) | 2005-01-15 |
| EP1281707B1 (en) | 2004-12-29 |
| ES2234797T3 (es) | 2005-07-01 |
| PT1281707E (pt) | 2005-04-29 |
| CA2456004A1 (en) | 2003-02-13 |
| TWI225055B (en) | 2004-12-11 |
| RO122147B1 (ro) | 2009-01-30 |
| KR20040043176A (ko) | 2004-05-22 |
| HUP0401166A3 (en) | 2007-05-29 |
| WO2003011846A2 (en) | 2003-02-13 |
| CN1555370A (zh) | 2004-12-15 |
| DE60108105D1 (de) | 2005-02-03 |
| WO2003011846A3 (en) | 2003-11-27 |
| WO2003011846B1 (en) | 2003-12-24 |
| BG108554A (bg) | 2005-03-31 |
| ZA200400841B (en) | 2005-02-02 |
| AU2002325385B8 (en) | 2003-02-17 |
| AR036212A1 (es) | 2004-08-18 |
| JP2005501056A (ja) | 2005-01-13 |
| DK1281707T3 (da) | 2005-05-02 |
| DE60108105T2 (de) | 2005-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |