CN1291102A - 选择性替代中枢神经系统中雌激素缺乏的药物制剂 - Google Patents

选择性替代中枢神经系统中雌激素缺乏的药物制剂 Download PDF

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Publication number
CN1291102A
CN1291102A CN99803170A CN99803170A CN1291102A CN 1291102 A CN1291102 A CN 1291102A CN 99803170 A CN99803170 A CN 99803170A CN 99803170 A CN99803170 A CN 99803170A CN 1291102 A CN1291102 A CN 1291102A
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CN
China
Prior art keywords
female
tetraene
ring
estradiol
estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99803170A
Other languages
English (en)
Chinese (zh)
Inventor
伏拉基米尔·帕切夫
迈克尔·厄特尔
伊娜·蒂姆
西格弗里德·施瓦茨
沃尔夫冈·勒默尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janepharm & Co KG GmbH
Jenapharm GmbH and Co KG
Original Assignee
Janepharm & Co KG GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998121831 external-priority patent/DE19821831A1/de
Application filed by Janepharm & Co KG GmbH filed Critical Janepharm & Co KG GmbH
Publication of CN1291102A publication Critical patent/CN1291102A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN99803170A 1998-02-20 1999-02-10 选择性替代中枢神经系统中雌激素缺乏的药物制剂 Pending CN1291102A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19807264.3 1998-02-20
DE19807264 1998-02-20
DE19821831.1 1998-05-15
DE1998121831 DE19821831A1 (de) 1998-05-15 1998-05-15 Pharmazeutische Präparate zur gezielten Substitution des Estrogenmangels im Zentralnervensystem

Publications (1)

Publication Number Publication Date
CN1291102A true CN1291102A (zh) 2001-04-11

Family

ID=26044035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99803170A Pending CN1291102A (zh) 1998-02-20 1999-02-10 选择性替代中枢神经系统中雌激素缺乏的药物制剂

Country Status (24)

Country Link
EP (1) EP1056460B1 (tr)
JP (1) JP2002503694A (tr)
KR (1) KR20010041107A (tr)
CN (1) CN1291102A (tr)
AT (1) ATE252388T1 (tr)
AU (1) AU739071C (tr)
BG (1) BG104689A (tr)
BR (1) BR9909205A (tr)
CA (1) CA2321498A1 (tr)
CZ (1) CZ291764B6 (tr)
DE (1) DE59907446D1 (tr)
EA (1) EA002707B1 (tr)
EE (1) EE03906B1 (tr)
HU (1) HUP0100742A3 (tr)
ID (1) ID27069A (tr)
IL (1) IL137727A0 (tr)
IS (1) IS5571A (tr)
NO (1) NO20004153L (tr)
NZ (1) NZ506049A (tr)
PL (1) PL342313A1 (tr)
SK (1) SK12152000A3 (tr)
TR (1) TR200002400T2 (tr)
UA (1) UA57830C2 (tr)
WO (1) WO1999042108A1 (tr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112189624A (zh) * 2020-09-08 2021-01-08 山东第一医科大学(山东省医学科学院) 一种利用受体基因沉默技术构建和鉴定女性ad模型的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2253318T3 (es) * 2001-11-07 2006-06-01 Schering Ag Cribado in vitro de ligandos del receptor de estrogeno.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897389A (en) * 1984-10-29 1990-01-30 Chaovanee Aroonsakul Treating central nervous system diseases
US4791099A (en) * 1984-10-29 1988-12-13 Chaovanee Aroonsakul Method of treatment for central nervous system diseases such as Alzheimer's's disease
DE4239946C2 (de) * 1992-11-27 2001-09-13 Jenapharm Gmbh Estranderivate mit einer 14alpha,15alpha-Methylengruppe und Verfahren zu ihrer Herstellung
US5554601A (en) * 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
DE4338314C1 (de) * 1993-11-10 1995-03-30 Jenapharm Gmbh Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE19524937A1 (de) * 1995-07-08 1997-01-09 Jenapharm Gmbh Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen und zur medikamentösen Substitution beim Mann
WO1997003661A1 (en) * 1995-07-24 1997-02-06 University Of Florida Research Foundation, Incorporated Use of non-estrogen polycyclic phenol compounds for the manufacture of a medicament for conferring neuroprotection to cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112189624A (zh) * 2020-09-08 2021-01-08 山东第一医科大学(山东省医学科学院) 一种利用受体基因沉默技术构建和鉴定女性ad模型的方法

Also Published As

Publication number Publication date
PL342313A1 (en) 2001-06-04
EP1056460B1 (de) 2003-10-22
EE200000477A (et) 2001-12-17
KR20010041107A (ko) 2001-05-15
AU2920999A (en) 1999-09-06
NZ506049A (en) 2002-09-27
CZ291764B6 (cs) 2003-05-14
JP2002503694A (ja) 2002-02-05
DE59907446D1 (de) 2003-11-27
BG104689A (en) 2001-04-30
EA002707B1 (ru) 2002-08-29
CZ20002938A3 (cs) 2001-01-17
WO1999042108A1 (de) 1999-08-26
TR200002400T2 (tr) 2000-11-21
EP1056460A1 (de) 2000-12-06
CA2321498A1 (en) 1999-08-26
ATE252388T1 (de) 2003-11-15
NO20004153L (no) 2000-10-09
HUP0100742A3 (en) 2002-07-29
UA57830C2 (uk) 2003-07-15
IL137727A0 (en) 2001-10-31
ID27069A (id) 2001-02-22
EA200000858A1 (ru) 2001-04-23
IS5571A (is) 2000-07-24
SK12152000A3 (sk) 2001-02-12
BR9909205A (pt) 2000-11-14
EE03906B1 (et) 2002-12-16
NO20004153D0 (no) 2000-08-18
HUP0100742A2 (hu) 2001-09-28
AU739071C (en) 2002-04-11
AU739071B2 (en) 2001-10-04

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CN1291102A (zh) 选择性替代中枢神经系统中雌激素缺乏的药物制剂

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