BR9909205A - Preparados farmacêuticos para a substituição visada da deficiência de estrogênio no sistema nervoso central - Google Patents
Preparados farmacêuticos para a substituição visada da deficiência de estrogênio no sistema nervoso centralInfo
- Publication number
- BR9909205A BR9909205A BR9909205-0A BR9909205A BR9909205A BR 9909205 A BR9909205 A BR 9909205A BR 9909205 A BR9909205 A BR 9909205A BR 9909205 A BR9909205 A BR 9909205A
- Authority
- BR
- Brazil
- Prior art keywords
- cns
- transcription
- estrogen
- estradiol
- central nervous
- Prior art date
Links
- 210000003169 central nervous system Anatomy 0.000 title abstract 8
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 206010030247 Oestrogen deficiency Diseases 0.000 title abstract 2
- 230000035897 transcription Effects 0.000 abstract 5
- 238000013518 transcription Methods 0.000 abstract 5
- 239000000262 estrogen Substances 0.000 abstract 4
- 229940011871 estrogen Drugs 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- VOXZDWNPVJITMN-SFFUCWETSA-N 17α-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-SFFUCWETSA-N 0.000 abstract 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 239000003687 estradiol congener Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002276 neurotropic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 210000004994 reproductive system Anatomy 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Abstract
Patente de Invenção: <B>PREPARADOS FARMACêUTICOS PARA A SUBSTITUIçãO VISADA DA DEFICIêNCIA DE ESTROGêNIO NO SISTEMA NERVOSO CENTRAL"<D>. A presente invenção refere-se o emprego de esteróides escolhidos para a produção de preparados farmacêuticos para a substituição visada da deficiência de estrogênios no sistema nervoso central (SNC) sem influenciar outros órgãos ou sistemas. Estes esteróides destacam-se pelo fato de que, ao contrário dos estrogênios naturais e sintéticos de efeito sistêmico, inclusive 17a-estradiol, possuem efeito de transcripção seletivo neurotrópico semelhente ao estrogênio. Verificou-se surpreendentemente, que os esteróides escolhidos em seu emprego de acordo com a invenção provocam uma influência seletiva da transcripção dos genes dependentes do estrogênio no SNC e alterações de parâmetros fisiológicos correspondentes apresentam feitos de transcripção específicos do SNC nestas doses, que em tecidos dos sistema reprodutor não têm nenhum efeito biológico; apresentam transcripção específica do SNC naquelas dosagens, mas quais nem o 17b-estradiol, nem o 17a-estradiol mostram uma eficácia; e a transcripção de genes dependentes de estrogênio no SNC não influencia sobre o efeito do 17b-estradiol formado secundariamente.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19807264 | 1998-02-20 | ||
| DE1998121831 DE19821831A1 (de) | 1998-05-15 | 1998-05-15 | Pharmazeutische Präparate zur gezielten Substitution des Estrogenmangels im Zentralnervensystem |
| PCT/DE1999/000353 WO1999042108A1 (de) | 1998-02-20 | 1999-02-10 | Pharmazeutische präparate zur gezielten substitution des estrogenmangels im zentralnervensystem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9909205A true BR9909205A (pt) | 2000-11-14 |
Family
ID=26044035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9909205-0A BR9909205A (pt) | 1998-02-20 | 1999-02-10 | Preparados farmacêuticos para a substituição visada da deficiência de estrogênio no sistema nervoso central |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1056460B1 (pt) |
| JP (1) | JP2002503694A (pt) |
| KR (1) | KR20010041107A (pt) |
| CN (1) | CN1291102A (pt) |
| AT (1) | ATE252388T1 (pt) |
| AU (1) | AU739071C (pt) |
| BG (1) | BG104689A (pt) |
| BR (1) | BR9909205A (pt) |
| CA (1) | CA2321498A1 (pt) |
| CZ (1) | CZ291764B6 (pt) |
| DE (1) | DE59907446D1 (pt) |
| EA (1) | EA002707B1 (pt) |
| EE (1) | EE03906B1 (pt) |
| HU (1) | HUP0100742A3 (pt) |
| ID (1) | ID27069A (pt) |
| IL (1) | IL137727A0 (pt) |
| IS (1) | IS5571A (pt) |
| NO (1) | NO20004153L (pt) |
| NZ (1) | NZ506049A (pt) |
| PL (1) | PL342313A1 (pt) |
| SK (1) | SK12152000A3 (pt) |
| TR (1) | TR200002400T2 (pt) |
| UA (1) | UA57830C2 (pt) |
| WO (1) | WO1999042108A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2253318T3 (es) | 2001-11-07 | 2006-06-01 | Schering Ag | Cribado in vitro de ligandos del receptor de estrogeno. |
| CN112189624A (zh) * | 2020-09-08 | 2021-01-08 | 山东第一医科大学(山东省医学科学院) | 一种利用受体基因沉默技术构建和鉴定女性ad模型的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791099A (en) * | 1984-10-29 | 1988-12-13 | Chaovanee Aroonsakul | Method of treatment for central nervous system diseases such as Alzheimer's's disease |
| US4897389A (en) * | 1984-10-29 | 1990-01-30 | Chaovanee Aroonsakul | Treating central nervous system diseases |
| DE4239946C2 (de) * | 1992-11-27 | 2001-09-13 | Jenapharm Gmbh | Estranderivate mit einer 14alpha,15alpha-Methylengruppe und Verfahren zu ihrer Herstellung |
| US5554601A (en) * | 1993-11-05 | 1996-09-10 | University Of Florida | Methods for neuroprotection |
| DE4338314C1 (de) * | 1993-11-10 | 1995-03-30 | Jenapharm Gmbh | Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen |
| DE4429397C2 (de) * | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| DE19524937A1 (de) * | 1995-07-08 | 1997-01-09 | Jenapharm Gmbh | Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen und zur medikamentösen Substitution beim Mann |
| JPH11510144A (ja) * | 1995-07-24 | 1999-09-07 | ユニバーシティー・オブ・フロリダ・リサーチ・ファンデーション・インコーポレーテッド | 細胞に神経保護を付与するための薬剤の製造のための非エストロゲン多環式フェノール化合物の使用 |
-
1999
- 1999-02-10 PL PL99342313A patent/PL342313A1/xx unknown
- 1999-02-10 CZ CZ20002938A patent/CZ291764B6/cs not_active IP Right Cessation
- 1999-02-10 SK SK1215-2000A patent/SK12152000A3/sk unknown
- 1999-02-10 EP EP99910118A patent/EP1056460B1/de not_active Expired - Lifetime
- 1999-02-10 ID IDW20001592A patent/ID27069A/id unknown
- 1999-02-10 EE EEP200000477A patent/EE03906B1/xx not_active IP Right Cessation
- 1999-02-10 TR TR2000/02400T patent/TR200002400T2/xx unknown
- 1999-02-10 NZ NZ506049A patent/NZ506049A/xx unknown
- 1999-02-10 KR KR1020007009148A patent/KR20010041107A/ko not_active Application Discontinuation
- 1999-02-10 DE DE59907446T patent/DE59907446D1/de not_active Expired - Fee Related
- 1999-02-10 HU HU0100742A patent/HUP0100742A3/hu unknown
- 1999-02-10 CA CA002321498A patent/CA2321498A1/en not_active Abandoned
- 1999-02-10 IL IL13772799A patent/IL137727A0/xx unknown
- 1999-02-10 JP JP2000532123A patent/JP2002503694A/ja not_active Abandoned
- 1999-02-10 WO PCT/DE1999/000353 patent/WO1999042108A1/de not_active Application Discontinuation
- 1999-02-10 AU AU29209/99A patent/AU739071C/en not_active Ceased
- 1999-02-10 EA EA200000858A patent/EA002707B1/ru not_active IP Right Cessation
- 1999-02-10 CN CN99803170A patent/CN1291102A/zh active Pending
- 1999-02-10 BR BR9909205-0A patent/BR9909205A/pt not_active IP Right Cessation
- 1999-02-10 AT AT99910118T patent/ATE252388T1/de not_active IP Right Cessation
- 1999-10-02 UA UA2000095399A patent/UA57830C2/uk unknown
-
2000
- 2000-07-24 IS IS5571A patent/IS5571A/is unknown
- 2000-08-15 BG BG104689A patent/BG104689A/xx unknown
- 2000-08-18 NO NO20004153A patent/NO20004153L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK12152000A3 (sk) | 2001-02-12 |
| CN1291102A (zh) | 2001-04-11 |
| AU739071C (en) | 2002-04-11 |
| EP1056460A1 (de) | 2000-12-06 |
| JP2002503694A (ja) | 2002-02-05 |
| IS5571A (is) | 2000-07-24 |
| BG104689A (en) | 2001-04-30 |
| UA57830C2 (uk) | 2003-07-15 |
| NO20004153D0 (no) | 2000-08-18 |
| HUP0100742A2 (hu) | 2001-09-28 |
| TR200002400T2 (tr) | 2000-11-21 |
| PL342313A1 (en) | 2001-06-04 |
| ATE252388T1 (de) | 2003-11-15 |
| KR20010041107A (ko) | 2001-05-15 |
| NZ506049A (en) | 2002-09-27 |
| EP1056460B1 (de) | 2003-10-22 |
| NO20004153L (no) | 2000-10-09 |
| HUP0100742A3 (en) | 2002-07-29 |
| EE03906B1 (et) | 2002-12-16 |
| DE59907446D1 (de) | 2003-11-27 |
| EA002707B1 (ru) | 2002-08-29 |
| IL137727A0 (en) | 2001-10-31 |
| EA200000858A1 (ru) | 2001-04-23 |
| CZ291764B6 (cs) | 2003-05-14 |
| AU739071B2 (en) | 2001-10-04 |
| EE200000477A (et) | 2001-12-17 |
| AU2920999A (en) | 1999-09-06 |
| CZ20002938A3 (cs) | 2001-01-17 |
| ID27069A (id) | 2001-02-22 |
| CA2321498A1 (en) | 1999-08-26 |
| WO1999042108A1 (de) | 1999-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A,8A,9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009. |