NZ506049A - Steroid derivatives; useful for selectively supplementing oestrogen deficiency in the central nervous system - Google Patents
Steroid derivatives; useful for selectively supplementing oestrogen deficiency in the central nervous systemInfo
- Publication number
- NZ506049A NZ506049A NZ506049A NZ50604999A NZ506049A NZ 506049 A NZ506049 A NZ 506049A NZ 506049 A NZ506049 A NZ 506049A NZ 50604999 A NZ50604999 A NZ 50604999A NZ 506049 A NZ506049 A NZ 506049A
- Authority
- NZ
- New Zealand
- Prior art keywords
- useful
- nervous system
- central nervous
- alkyl
- independently
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The steroids of the formula shown are useful for selectively supplementing estrogen deficiency in the central nervous system without affecting other organs or systems. The variables are defined as follows: R1 is H, -OH, or alkoxy; R2 is H, alkyl, acyl, or -SO2NR10R11 (where R10 and R11 are independently H or alkyl, or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino ring); R3 is H or -OH; R4 is H, -OH, or alkyl; R5 and R6 are independently H or halogen; R7 is H or methyl; R8 is H, -OH, =O, or a group of formula -CR12R13 (in which R12 and R13 are independently H or halogen); R9 is methyl or ethyl; Z is a C,C double bond or an optionally substituted cyclopropane ring; The >CR5R6 is either in the a or b position, R7 being in the b position if >CR5R6 is in the a position, and vice versa.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19807264 | 1998-02-20 | ||
| DE1998121831 DE19821831A1 (en) | 1998-05-15 | 1998-05-15 | Selectively supplementing estrogen deficiency in the central nervous system, using 14,15-cyclopropano estrane steroid compounds |
| PCT/DE1999/000353 WO1999042108A1 (en) | 1998-02-20 | 1999-02-10 | Pharmaceutical preparations for selectively supplementing oestrogen deficiency in the central nervous system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ506049A true NZ506049A (en) | 2002-09-27 |
Family
ID=26044035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ506049A NZ506049A (en) | 1998-02-20 | 1999-02-10 | Steroid derivatives; useful for selectively supplementing oestrogen deficiency in the central nervous system |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1056460B1 (en) |
| JP (1) | JP2002503694A (en) |
| KR (1) | KR20010041107A (en) |
| CN (1) | CN1291102A (en) |
| AT (1) | ATE252388T1 (en) |
| AU (1) | AU739071C (en) |
| BG (1) | BG104689A (en) |
| BR (1) | BR9909205A (en) |
| CA (1) | CA2321498A1 (en) |
| CZ (1) | CZ291764B6 (en) |
| DE (1) | DE59907446D1 (en) |
| EA (1) | EA002707B1 (en) |
| EE (1) | EE03906B1 (en) |
| HU (1) | HUP0100742A3 (en) |
| ID (1) | ID27069A (en) |
| IL (1) | IL137727A0 (en) |
| IS (1) | IS5571A (en) |
| NO (1) | NO20004153L (en) |
| NZ (1) | NZ506049A (en) |
| PL (1) | PL342313A1 (en) |
| SK (1) | SK12152000A3 (en) |
| TR (1) | TR200002400T2 (en) |
| UA (1) | UA57830C2 (en) |
| WO (1) | WO1999042108A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2253318T3 (en) * | 2001-11-07 | 2006-06-01 | Schering Ag | IN VITRO LIGAND CROSSING OF THE STROGEN RECEIVER. |
| CN112189624A (en) * | 2020-09-08 | 2021-01-08 | 山东第一医科大学(山东省医学科学院) | Method for constructing and identifying female AD model by using receptor gene silencing technology |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897389A (en) * | 1984-10-29 | 1990-01-30 | Chaovanee Aroonsakul | Treating central nervous system diseases |
| US4791099A (en) * | 1984-10-29 | 1988-12-13 | Chaovanee Aroonsakul | Method of treatment for central nervous system diseases such as Alzheimer's's disease |
| DE4239946C2 (en) * | 1992-11-27 | 2001-09-13 | Jenapharm Gmbh | Estrane derivatives with a 14alpha, 15alpha-methylene group and process for their preparation |
| US5554601A (en) * | 1993-11-05 | 1996-09-10 | University Of Florida | Methods for neuroprotection |
| DE4338314C1 (en) * | 1993-11-10 | 1995-03-30 | Jenapharm Gmbh | Pharmaceutical preparations for the prophylaxis and therapy of radical-mediated cell damage |
| DE4429397C2 (en) * | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5 (10) -triene derivatives, processes for their preparation and pharmaceutical compositions containing these compounds |
| DE19524937A1 (en) * | 1995-07-08 | 1997-01-09 | Jenapharm Gmbh | Pharmaceutical preparations for the prophylaxis and therapy of radical-mediated cell damage and for drug substitution in men |
| WO1997003661A1 (en) * | 1995-07-24 | 1997-02-06 | University Of Florida Research Foundation, Incorporated | Use of non-estrogen polycyclic phenol compounds for the manufacture of a medicament for conferring neuroprotection to cells |
-
1999
- 1999-02-10 AU AU29209/99A patent/AU739071C/en not_active Ceased
- 1999-02-10 ID IDW20001592A patent/ID27069A/en unknown
- 1999-02-10 EP EP99910118A patent/EP1056460B1/en not_active Expired - Lifetime
- 1999-02-10 WO PCT/DE1999/000353 patent/WO1999042108A1/en not_active Application Discontinuation
- 1999-02-10 CA CA002321498A patent/CA2321498A1/en not_active Abandoned
- 1999-02-10 CN CN99803170A patent/CN1291102A/en active Pending
- 1999-02-10 SK SK1215-2000A patent/SK12152000A3/en unknown
- 1999-02-10 KR KR1020007009148A patent/KR20010041107A/en not_active Application Discontinuation
- 1999-02-10 TR TR2000/02400T patent/TR200002400T2/en unknown
- 1999-02-10 NZ NZ506049A patent/NZ506049A/en unknown
- 1999-02-10 JP JP2000532123A patent/JP2002503694A/en not_active Abandoned
- 1999-02-10 CZ CZ20002938A patent/CZ291764B6/en not_active IP Right Cessation
- 1999-02-10 HU HU0100742A patent/HUP0100742A3/en unknown
- 1999-02-10 BR BR9909205-0A patent/BR9909205A/en not_active IP Right Cessation
- 1999-02-10 EE EEP200000477A patent/EE03906B1/en not_active IP Right Cessation
- 1999-02-10 DE DE59907446T patent/DE59907446D1/en not_active Expired - Fee Related
- 1999-02-10 AT AT99910118T patent/ATE252388T1/en not_active IP Right Cessation
- 1999-02-10 PL PL99342313A patent/PL342313A1/en unknown
- 1999-02-10 EA EA200000858A patent/EA002707B1/en not_active IP Right Cessation
- 1999-02-10 IL IL13772799A patent/IL137727A0/en unknown
- 1999-10-02 UA UA2000095399A patent/UA57830C2/en unknown
-
2000
- 2000-07-24 IS IS5571A patent/IS5571A/en unknown
- 2000-08-15 BG BG104689A patent/BG104689A/en unknown
- 2000-08-18 NO NO20004153A patent/NO20004153L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL342313A1 (en) | 2001-06-04 |
| EP1056460B1 (en) | 2003-10-22 |
| CN1291102A (en) | 2001-04-11 |
| EE200000477A (en) | 2001-12-17 |
| KR20010041107A (en) | 2001-05-15 |
| AU2920999A (en) | 1999-09-06 |
| CZ291764B6 (en) | 2003-05-14 |
| JP2002503694A (en) | 2002-02-05 |
| DE59907446D1 (en) | 2003-11-27 |
| BG104689A (en) | 2001-04-30 |
| EA002707B1 (en) | 2002-08-29 |
| CZ20002938A3 (en) | 2001-01-17 |
| WO1999042108A1 (en) | 1999-08-26 |
| TR200002400T2 (en) | 2000-11-21 |
| EP1056460A1 (en) | 2000-12-06 |
| CA2321498A1 (en) | 1999-08-26 |
| ATE252388T1 (en) | 2003-11-15 |
| NO20004153L (en) | 2000-10-09 |
| HUP0100742A3 (en) | 2002-07-29 |
| UA57830C2 (en) | 2003-07-15 |
| IL137727A0 (en) | 2001-10-31 |
| ID27069A (en) | 2001-02-22 |
| EA200000858A1 (en) | 2001-04-23 |
| IS5571A (en) | 2000-07-24 |
| SK12152000A3 (en) | 2001-02-12 |
| BR9909205A (en) | 2000-11-14 |
| EE03906B1 (en) | 2002-12-16 |
| NO20004153D0 (en) | 2000-08-18 |
| HUP0100742A2 (en) | 2001-09-28 |
| AU739071C (en) | 2002-04-11 |
| AU739071B2 (en) | 2001-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |