CN1289062C - 化装料 - Google Patents
化装料 Download PDFInfo
- Publication number
- CN1289062C CN1289062C CNB2004100485102A CN200410048510A CN1289062C CN 1289062 C CN1289062 C CN 1289062C CN B2004100485102 A CNB2004100485102 A CN B2004100485102A CN 200410048510 A CN200410048510 A CN 200410048510A CN 1289062 C CN1289062 C CN 1289062C
- Authority
- CN
- China
- Prior art keywords
- yeast
- cosmetic material
- cell
- extract
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 28
- 239000000463 material Substances 0.000 title claims abstract description 28
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 30
- 239000003125 aqueous solvent Substances 0.000 claims abstract description 10
- 241000235346 Schizosaccharomyces Species 0.000 claims abstract description 9
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims abstract description 5
- 239000004615 ingredient Substances 0.000 claims description 7
- 238000000638 solvent extraction Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 41
- 239000000284 extract Substances 0.000 abstract description 24
- 102000003425 Tyrosinase Human genes 0.000 abstract description 6
- 108060008724 Tyrosinase Proteins 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000008099 melanin synthesis Effects 0.000 abstract 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 45
- 230000004927 fusion Effects 0.000 description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- 239000012138 yeast extract Substances 0.000 description 30
- 229940041514 candida albicans extract Drugs 0.000 description 28
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 17
- 239000001963 growth medium Substances 0.000 description 17
- 210000003491 skin Anatomy 0.000 description 17
- 102000004190 Enzymes Human genes 0.000 description 14
- 108090000790 Enzymes Proteins 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 11
- 239000012153 distilled water Substances 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 9
- 230000002087 whitening effect Effects 0.000 description 9
- 238000000605 extraction Methods 0.000 description 8
- 241000235343 Saccharomycetales Species 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- 230000037303 wrinkles Effects 0.000 description 5
- 229920000832 Cutin Polymers 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000012531 culture fluid Substances 0.000 description 4
- 230000009849 deactivation Effects 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241001597008 Nomeidae Species 0.000 description 3
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 230000019612 pigmentation Effects 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- KVYRCBOUKXJXDK-UHFFFAOYSA-N 3,4-dimethylphenazine-1,2-diamine hydrochloride Chemical class Cl.C1=CC=CC2=NC3=C(C)C(C)=C(N)C(N)=C3N=C21 KVYRCBOUKXJXDK-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 2
- 244000024675 Eruca sativa Species 0.000 description 2
- 235000014755 Eruca sativa Nutrition 0.000 description 2
- 208000001382 Experimental Melanoma Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 description 2
- 230000032823 cell division Effects 0.000 description 2
- 229940106189 ceramide Drugs 0.000 description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 2
- 210000004748 cultured cell Anatomy 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000010612 desalination reaction Methods 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000002934 lysing effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 241000307523 Xenostegia media Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000020053 arrack Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 description 1
- 230000004993 binary fission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 150000001636 bornane derivatives Chemical class 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229920003064 carboxyethyl cellulose Polymers 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 150000002461 imidazolidines Chemical class 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 229960003951 masoprocol Drugs 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- VLAPMBHFAWRUQP-UHFFFAOYSA-L molybdic acid Chemical compound O[Mo](O)(=O)=O VLAPMBHFAWRUQP-UHFFFAOYSA-L 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- VWMVAQHMFFZQGD-UHFFFAOYSA-N p-Hydroxybenzyl acetone Natural products CC(=O)CC1=CC=C(O)C=C1 VWMVAQHMFFZQGD-UHFFFAOYSA-N 0.000 description 1
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- -1 polyethylene methacrylate Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- NJGBTKGETPDVIK-UHFFFAOYSA-N raspberry ketone Chemical compound CC(=O)CCC1=CC=C(O)C=C1 NJGBTKGETPDVIK-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明提供一种化妆料,具有基于酵母提取成分的酪氨酸酶活性抑制作用和黑色素生成抑制作用,而且具有清除活性氧或细胞激活活性,具有综合的优良皮肤美白效果。作为有效成分含有Schizosaccharomycespombe等Schizosccharommyces属酵母的水性溶剂提取物,含量为 0.05-10重量%的。
Description
技术领域
本发明涉及化装料,详细说是涉及含有具有皮肤细胞激活作用或美白作用的酵母成分的化装料。
背景技术
一般认为,日晒或粉刺后出现的色素沉积,更年期女性频发的肝斑,伴随老化出现的老年性色斑等症状均是由于作为黑褐色色素的黑色素的生成而引起的。
黑色素是当皮肤受到紫外线等外界刺激时,存在于皮肤黑色素细胞中的酪氨酸酶活化,作为一种氨基酸的酪氨酸被氧化而生成的。因此,通过抑制与黑色素生成相关的酪氨酸酶的活性,可以期待使皮肤变白的美白效果,也可以将酪氨酸酶活性抑制成分与化装料配合使用。
但是,即使将酪氨酸酶活性抑制成分与化装料配合使用,许多化装料对B16黑素瘤培养细胞中的黑色素生成的抑制效果也不充分,实际用于皮肤上对色素的淡化效果并不充分。
这样为了使化装料确实发挥美白效果,仅有上述的酪氨酸酶活性抑制效果或黑色素生成抑制效果是不充分的,有必要使其发挥通过消除活性氧而抑制色素沉积的作用或通过激活表皮细胞而促进黑色素排泄的作用。
作为以往配合使用酵母的化装料,已知配合使用由Saccharomyces属酵母培养液得到的发酵液作为有效成分的具有美白效果的化装料。(参照特许文献1)。
另外,已知有活化皮肤表层内部表皮细胞自身的神经酰胺合成,改善皮肤屏障机能的神经酰胺合成促进剂(参照特许文献2),和配合使用覆盆子酮D糖苷(β)等配糖体和酵母提取物或含有这些成分的菌培养物的美白化装料(参照特许文献3)。
特许文献1 特开平7-10734号公报
特许文献2 特开平8-217658号公报
特许文献3 特开2000-109408号公报
上述以往的美白化装料,虽然单独配合使用酵母提取物,或配合使用酵母提取物和配糖体,但是除了发挥前述的酪氨酸酶活性抑制作用或黑色素生成抑制作用外,为了确实得到基于更综合的作用的美白效果还有改良的余地。
发明内容
因此本发明的课题就是解决上述以往技术的问题点,制做通过酵母提取成分具有酪氨酸酶活性抑制作用和黑色素生成抑制作用,而且具有消除活性氧或细胞激活作用,具有综合的优良皮肤美白效果的化装料。
解决课题的手段
发明者对通过分裂而增殖的酵母进行遗传学分析发现,这一酵母与出芽酵母相比是具有与人的细胞更接近的增殖形态的分裂细胞,判断其中含有以往酵母提取物中没有的具有较高有效成分的可能性较高,这一分裂酵母属于Schizosaccharomyces属,通过将其细胞提取液或孢子提取液对皮肤的效果与其他酵母相比较进行实际调查发现,只有这一属兼备上述各效果,由此完成了本发明。
即为解决前述课题,在本发明的化装料中,作为有效成分含有Schizosaccharomyces属酵母的水性溶剂提取物。
由后述实验结果可知,Schizosaccharomyces属酵母的水性溶剂提取物具有促进纤维芽细胞分裂而生成正常新细胞的所谓的细胞激活作用的同时还有黑色素生成抑制作用,它们协同作用的结果就形成了具有优良皮肤美白效果的化装料。
为了使化装料确实发挥这一优良作用,优选采用Schizosaccharomyces属酵母Schizosaccharomyces pombe的化装料。
另外,化装料中水性溶剂提取物作为有效成分的更好的含量为0.05~10重量%。
附图说明
图1是表示涂布化装水的皮肤的黑色素量经时变化的图表。
图2是表示涂布化装水的皮肤的角质水分量经时变化的图表。
具体实施方式
本发明使用的酵母属于子囊菌类单细胞真核微生物,属于象动物细胞进行均等的二分裂的Schizosaccharomyces属酵母(以下称为分裂酵母),作为代表可列举出Schizosaccharomyces pombe。Schizo表示分裂的意思。Schizosaccharomyces pombe自古被应用于食品领域中,1890年代由东非的pombe中分离出来而被广泛认识,分裂酵母广泛应用于葡萄汁,椰子酒,甘蔗,果汁,面包,啤酒酿造等领域中,可以很容易得到市售品,而且其安全性也被公众确认。
分裂酵母在营养源丰富时通过体细胞分裂过程进行增殖,如果营养缺乏则在性外激素的存在下接合后形成孢子进行有性生殖。
培养这样的分裂酵母所用的培养基,可以是通常使用的酵母用培养基,如想分别得到酵母细胞或孢子,优选使用合成培养基,另外孢子形成培养基中不加氮源。培养条件,例如温度或时间,一般适用进行酵母培养的条件。
分裂酵母的细胞及孢子的具体提取方法如下
即,回收培养后的菌体,用蒸馏水等充分洗涤后以培养液的1/10量蒸馏水混悬。然后加入2.5mg/ml浓度的细胞壁分解酶,37℃反应4天。另外,关于培养时间(天数),例如可以培养基的温度等为指标,以其达到稳定期为目标。
然后使酶失活,进行离心分离等操作后过滤(利用酵母的自我消化时,加入相当于洗涤后湿菌体10~100倍量的蒸馏水,35~45℃下,搅拌24~72小时使其自我消化,然后进行冷冻干燥或减压浓缩。)。在其中加入相当于湿菌体10~100倍量的水,乙醇,丁二醇,丙二醇,甘油等水性溶剂中的一种或几种的混合溶剂,进行离心分离等操作后过滤。
利用酶分解法的情况中,加入相当于洗涤后的湿菌体10~100倍量的蒸馏水,再按相对于每1kg酵母菌体20~50万单位的程度加入蛋白水解酶,在保持酶活性的温度下使其反应1昼夜。
使酶失活后,添加适量的水性溶剂,或不添加,进行离心分离等分离操作后过滤。利用酸分解法的情况中,加入相当于洗涤后湿菌体10倍量的1~5%盐酸,在40~60℃反应3~8小时,经常搅拌进行水解反应。然后用碱中和,再用同样方法处理。另外,中和后最好用透析处理等方法脱盐。
本发明中分裂酵母提取物作为有效成分的配合量,通过在化装料处方中配合使用0.05~10重量%(优选2~5重量%),可以充分发挥本发明所预期的效果,即皮肤美白效果,活性氧消去效果,细胞激活效果。
另外,本发明中的分裂酵母水性溶剂提取物可以作为化装品或浴用剂与常用的基剂,药剂等共同组方,制成任意形态的化装品。
例如作为可与分裂酵母的水性溶剂提取物配合的适当的油分,代表例为动植物油,矿物油,此外还可列举出酯油,蜡油,高级醇,脂肪酸类,硅油,磷脂等油或油脂。
另外,作为表面活性剂,可列举出阴离子表面活性剂,阳离子表面活性剂,两性表面活性剂,非离子表面活性剂等。另外根据需要并用对氨基安息香酸,邻氨基苯甲酸衍生物,苯并三唑衍生物,四唑衍生物,咪唑啉衍生物,嘧啶衍生物,二氧六环衍生物,莰烷衍生物,呋喃衍生物,吡喃衍生物,核酸衍生物,尿囊素衍生物,烟酸衍生物,紫草素,维生素B6衍生物等紫外线吸收剂,抗坏血酸及其盐,硬脂酸酯,维生素E及其酯衍生物,去甲二氢愈创木酸,丁羟甲苯(BHT),丁羟茴醚(BHA),对羟基茴香醚,没食子酸丙酯等抗氧化剂,羟乙基纤维素,甲基纤维素,乙基纤维素,羧甲基纤维素,羧乙基纤维素,阿拉伯胶,聚乙二醇,聚乙烯吡咯烷酮,聚乙烯甲基丙烯酸酯,聚丙烯酸盐,羧乙烯聚合物,角叉菜胶,果胶,海藻酸及其盐,酪蛋白,明胶等增粘剂,甘油,丙二醇,1,3-丁二醇,透明质酸及其盐,聚乙二醇,硫酸软骨素及其盐,水溶性几丁质或脱乙酰几丁质衍生物,乳酸钠等保湿剂,低级醇,多价醇,水溶性高分子,pH调节剂,螯合剂,防腐剂,防霉剂,香料,着色料,清凉剂,稳定化剂,源于动植物的提取物,动植物蛋白质及其分解物,源于动植物的提取物,动植物多糖类及其分解物,源于动植物的提取物,动植物糖蛋白及其分解物,血流促进剂,消炎抗炎剂,细胞激活剂,维生素类,氨基酸及其盐,核质溶解剂,收敛剂,创伤治愈剂,增泡剂,消臭脱臭剂等,可制成前述的各种化装品。
本发明的化装料可作为化装品、医药用外用品而预防和改善色素沉积,或以激活皮肤细胞为目的应用,其形态可列举出面霜,软膏,乳液,美容液,化装水,面膜,浴用剂,化装用化装料等,其剂型没有特别限制。
实施例及比较例
(分裂酵母的培养例1)
分别配制如下组成的培养基1,2,向培养基1中加入1白金耳分裂酵母,30℃培养3天。该培养液离心分离回收菌体,将菌体全量混悬于同量的培养基2中,培养5天。该培养液离心分离,回收菌体以蒸馏水充分洗涤。
(培养基1)葡萄糖 30g
酵母提取物 5g
(培养基2)葡萄糖 10g
磷酸二氢钾 0.25g
硫酸镁 0.5g
氯化钙 0.1g
硼酸 0.5mg
硫酸铜 40μg
碘化钾 0.1mg
氯化铁 0.2mg
硫酸锰 0.4mg
钼酸 0.16mg
硫酸锌 0.4mg
生物素 1μg
泛酸钙 1mg
烟酸 10mg
肌醇 10mg
(分裂酵母的培养例2)
配制前述相同的培养基1,加入分裂酵母(1白金耳),30℃培养10天。培养液离心分离回收菌体,以蒸馏水充分洗涤。
(分裂酵母提取物的提取例1)
前述培养例1所得分裂酵母(0.1~1.0kg)混悬于培养用量1/10的蒸馏水中。向混悬液中加入终浓度为2.5mg/ml的酶(LYSING ENZYMES,LotNo.69H1557,SIGMA)30℃酶处理4天。酶处理后将混悬液超声波处理,使全量为100ml。溶液在90℃下加热处理1小时使酶失活,用滤过助剂,滤纸,膜滤器进行过滤。
(分裂酵母提取物的提取例2)
培养例2所得分裂酵母(0.1~1.0kg)混悬于培养用量1/10的蒸馏水中。向混悬液中加入终浓度为2.5mg/ml的酶(LYSING ENZYMES,LotNo.69H1557,SIGMA)30℃酶处理4天。酶处理后将混悬液超声波处理,使全量为100ml。溶液在90℃下加热处理1小时使酶失活,用滤过助剂,滤纸,膜滤器进行过滤。
[比较提取例1,2](出芽酵母提取物)
市售以出芽酵母Saccharomyces cerevisiae为提取原料的甲公司制酵母提取物作为比较提取例1,乙公司制酵母提取物作为比较提取例2。
[黑色素合成抑制作用的比较实验]
前述提取例1或2的分裂酵母提取物及市售出芽酵母提取物比较提取例1,2作为试样,进行黑素瘤细胞的黑色素合成抑制作用的比较实验。
作为实验方法,将B16小鼠黑素瘤细胞在含有10%FBS的MEM培养基中37℃,5%CO2条件下培养,以此作为实验用样品。详细说,将1T:×5个B16黑素瘤细胞植入60mm塑料培养皿中,培养24小时。然后更换新鲜培养基,分别向培养基中添加终浓度为2%的实验样品。添加后3天,将细胞用胰蛋白酶处理回收,以1N NaOH,10%DMSO的溶液加热溶解,测定475nm处的吸光度。另外,将未处理细胞的黑色素合成率作为100%计算出样品添加时的黑色素合成率。黑色素合成抑制率是由未处理的黑色素合成率(100%)中减去添加样品时的黑色素合成率。其结果作为黑色素生成抑制率(%)如表1所示。
表1
样品 | 抑制率(%) |
提取例1的分裂酵母提取物 | 62 |
提取例2的分裂酵母提取物 | 66 |
比较提取例1(市售品) | 21 |
比较提取例2(市售品) | 51 |
表1的结果显示,提取例1或提取例2所得分裂酵母提取物具有黑色素生成抑制作用,可以期待防止皱纹,雀斑等的效果,其效果与作为比较提取例1,2的市售出芽酵母提取物相比要高。
[细胞激活作用(细胞增殖)的比较实验]
前述提取例1或提取例2的分裂酵母提取物及市售出芽酵母提取物比较提取例1,2作为试样,进行细胞激活作用(细胞增殖)的比较实验。
考察激活作用的对象细胞,使用正常人皮肤纤维芽细胞NB1RGB在含有5%FBS的MEM培养基中培养的细胞。另外培养要完全在37℃,5%CO2条件下进行。详细说明,首先将0.5×104个正常人纤维芽细胞接种于采用含有5%FBS的MEM培养基的96孔微型板中,培养24小时。将培养液交换为加入实验试样的含有5%FBS的MEM培养基的培养基中培养9天。将培养液交换到含有50μg/ml中性红和5%FBS的MEM培养基中培养2小时,弃去培养液后以1%CaCl2,1%福尔马林液洗涤微型板一次。向其中添加1%醋酸,50%乙醇水溶液,提取含在细胞的中性红,以微型板读出器测定其在570nm处的吸收波长,结果如表2所示。
表2
试样/细胞增殖率(%) | 样品浓度(%) | ||||||
0 | 0.3125 | 0.625 | 1.25 | 2.50 | 5.00 | 10.0 | |
提取例1(分裂酵母提取物) | 100.00 | 123.65 | 141.31 | 162.74 | 194.02 | 236.00 | 278.29 |
比较提取例1 | 100.00 | 135.33 | 146.67 | 146.67 | 186.67 | 210.00 | 166.67 |
比较提取例2 | 100.00 | 121.33 | 133.33 | 163.33 | 183.33 | 193.33 | 166.67 |
由表2的结果可知,分裂酵母提取物具有促进细胞增殖作用,即细胞激活作用,由这一作用可期待促进皮肤角化细胞,纤维芽细胞的增殖,改善皮肤状态的效果。另外,可以确认与比较提取例1,2的出芽酵母提取物相比,其效果要高。
[化装水的制造和功能评价]
按表3所示配合比例,分别制造配合使用分裂酵母提取物(提取例1)的实施例1的化装水,作为比较例1,2,配合使用比较提取例1,2的化装水。另外,比较例3是不含酵母提取物的空白品,各实施例及比较例中配合适量的防腐剂和pH调节剂。
以上样品用于受试小组成员(成人男女各10人)的皮肤(面部),每日早晚两次,使用2个月,2个月后调查功能结果。调查项目有如表4所示的5个项目,分5个等级进行评价,其平均值如表3所示。
表3
成分(wt%) | 实施例 | 比较例 | ||
1 | 1 | 2 | 3 | |
分裂酵母提取物 | 2.5 | 0 | 0 | 0 |
蒸馏水 | 0 | 0 | 0 | 2.5 |
以往的酵母提取物1 | 0 | 2.5 | 0 | 0 |
以往的酵母提取物2 | 0 | 0 | 2.5 | 0 |
甘油 | 10 | 10 | 10 | 10 |
还原麦芽糖 | 3 | 3 | 3 | 3 |
乙醇 | 5 | 5 | 5 | 5 |
蒸馏水 | 以全量为100的余份 | 以全量为100的余份 | 以全量为100的余份 | 以全量为100的余份 |
试验项目 | ||||
1湿润感 | 4.3 | 3.1 | 2.9 | 2.3 |
2明暗度 | 4.5 | 2.9 | 3.2 | 1.8 |
3肌肤粗糙的改善 | 4.7 | 3.5 | 3.6 | 2 |
4皱纹改善 | 4.8 | 3.7 | 3.6 | 1.5 |
5综合评价 | 4.7 | 3.5 | 3.5 | 2.4 |
表4
评分 | 湿润感 | 肌肤的明暗度 | 肌肤粗糙的改善 | 小皱纹的减少 |
5 | 非常湿润 | 变的非常光泽 | 明显改善 | 小皱纹明显减少 |
4 | 稍微湿润 | 变的光泽 | 得到改善 | 小皱纹减少 |
3 | 普通 | 稍微变的光泽 | 稍微得到改善 | 小皱纹稍微减少 |
2 | 稍差 | 没有变化 | 没有变化 | 没有变化 |
1 | 非常差 | 稍微变暗 | 变坏 | 小皱纹增加 |
[涂布化装水的皮肤的美白作用确认实验]
用使用表3所示组成的实施例1的分裂酵母提取物、比较例1、2、3的化装水,进行美白效果实验(皮肤黑色素量测定实验)。即每天2次涂布于受试小组成员(成人男女各10人)的皮肤(面部),使用3个月,用CK社制美白效果试验机(MEXAMETER MX18)测定黑色素量,结果如图1所示。
由图1的结果可知,配合使用实施例1的分裂酵母所得的提取物的化装水,由第70天到3个月的期间,明显地比以往的化装水显示优良的黑色素量的减少效果。
[涂布化装水的皮肤的角质水分量变化]
以使用表3所示组成的实施例1的分裂酵母提取物、比较例1、2、3的化装水涂布皮肤,用CK社制水分量测定试验机(SKICOS301)测定其角质水分量的经时变化(到涂布后540分钟),结果如图2所示。
图2结果表明,配合使用由实施例1的分裂酵母所得提取物的化装水,在涂布后120分钟明确开始显示比以往化装水优良的角质水分保持量。
应用本发明的分裂酵母提取物的化装料如以上说明的,是作为有效成分含有Schizosaccharomyces属酵母的水性溶剂提取物的化装料,具有优良的黑色素生成抑制作用,即具有美白作用,另外还发挥显著的细胞激活作用。这样的效果与以往的含有出芽酵母或其提取物的化装料的效果相比是有利的。
Claims (2)
1.一种化装料,作为有效成分含有Schizosaccharomyces属酵母的水性溶剂提取物,其中,Schizosaccharomyces属酵母是Schizosaccharomycespombe。
2.根据权利要求1所述的化装料,其中,作为有效成分的含量为0.05~10重量%。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003163513 | 2003-06-09 | ||
JP2003163513A JP3806419B2 (ja) | 2003-06-09 | 2003-06-09 | 化粧料 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1572292A CN1572292A (zh) | 2005-02-02 |
CN1289062C true CN1289062C (zh) | 2006-12-13 |
Family
ID=33296781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100485102A Expired - Lifetime CN1289062C (zh) | 2003-06-09 | 2004-06-07 | 化装料 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040247559A1 (zh) |
EP (1) | EP1486201B1 (zh) |
JP (1) | JP3806419B2 (zh) |
KR (1) | KR20040105601A (zh) |
CN (1) | CN1289062C (zh) |
DE (1) | DE602004018569D1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7291340B2 (en) * | 2005-12-29 | 2007-11-06 | Elc Management Llc | Extracts from black yeast for whitening skin |
FR2904551B1 (fr) * | 2006-08-03 | 2012-10-19 | Soc Extraction Principes Actif | Utilisation d'un extrait de levure en tant qu'agent actif pour augmenter la synthese de melanine dans les melanocytes |
FR2904552B1 (fr) * | 2006-08-03 | 2012-09-21 | Soc Extraction Principes Actif | Utilisation d'un extrait de levure en tant qu'agent actif pour augmenter la synthese de melanine dans les melanocytes |
US7862822B2 (en) * | 2007-09-25 | 2011-01-04 | Elc Management Llc | Extracts from black yeast for whitening skin |
KR20110036299A (ko) * | 2009-10-01 | 2011-04-07 | (주)아모레퍼시픽 | 누룩 추출물을 함유하는 항노화 및 미백용 화장료 조성물 |
EP2540170A1 (de) * | 2011-06-29 | 2013-01-02 | Evonik Degussa GmbH | Dermatologisch wirksamer Hefeextrakt |
JP6704628B2 (ja) * | 2014-02-18 | 2020-06-03 | 共栄化学工業株式会社 | 化粧料 |
CN105434323B (zh) * | 2015-12-22 | 2018-06-19 | 广州市娇兰化妆品有限公司 | 酵母菌发酵复方组合物及其在美白保湿护肤品中的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1261173A (fr) * | 1958-05-22 | 1961-05-19 | Produits diététiques et cosmétiques améliorés au moyen des cultures de micro-organismes se développant sur des solutions de glucides | |
JPS61236727A (ja) * | 1985-04-12 | 1986-10-22 | Advance Res & Dev Co Ltd | 抗う蝕乃至抗菌周症剤 |
EP0208805A1 (de) * | 1985-07-19 | 1987-01-21 | Socop Nahrungsmittel Gmbh | Verfahren zur Herstellung thallophytischer oder bryophytischer Zytorrhysate, danach hergestellte Chemizytorrhysate und deren Verwendung zur Nährstoffergänzung |
JPH01148181A (ja) * | 1987-12-07 | 1989-06-09 | Jgc Corp | グルタチオンの菌体内蓄積法 |
DE4138192A1 (de) * | 1990-08-30 | 1993-05-27 | Karin Omlor | Mittel auf pflanzlicher basis, zur erneuerung der haut bei frischen brandverletzungen, zur reinigung unreiner haut, zur bekaempfung von krampfadern, zum abklingen von schwellungen bei verletzungen, zum abklingen von schwellungen und juckreiz bei insektenstichen, bei aeusserlicher anwendung |
DE19629118C2 (de) * | 1996-07-19 | 2001-11-29 | Mibelle Ag Cosmetics Buchs | Verfahren zur Isolierung von Glucan aus Hefe |
JP4077157B2 (ja) * | 1998-06-08 | 2008-04-16 | エモリー・ユニバーシティ | 広範な特異性のdna損傷エンドヌクレアーゼ |
FR2809308B1 (fr) * | 2000-05-29 | 2003-12-26 | Seporga Lab | Preparations cosmetiques ou dermo-pharmaceutiques contenant des hsp et hsf provenant d'un extrait de champignons ou de levures stresses |
BR0017361A (pt) * | 2000-10-16 | 2004-03-23 | Biocosmetics Sl | Uso de azeite de oliva na preparação de um produto para higiene oral |
FR2843023B1 (fr) * | 2002-07-30 | 2004-09-24 | Sederma Sa | Compositions cosmetiques ou dermopharmaceutiques contenant du kombucha. |
US7585518B2 (en) * | 2002-11-19 | 2009-09-08 | Kimberly-Clark Worldwide, Inc. | Products and methods for maintaining or increasing ceramide levels in skin |
-
2003
- 2003-06-09 JP JP2003163513A patent/JP3806419B2/ja not_active Expired - Fee Related
-
2004
- 2004-06-07 KR KR1020040041296A patent/KR20040105601A/ko not_active Application Discontinuation
- 2004-06-07 CN CNB2004100485102A patent/CN1289062C/zh not_active Expired - Lifetime
- 2004-06-08 EP EP04013502A patent/EP1486201B1/en not_active Expired - Lifetime
- 2004-06-08 DE DE602004018569T patent/DE602004018569D1/de not_active Expired - Lifetime
- 2004-06-09 US US10/863,368 patent/US20040247559A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1486201B1 (en) | 2008-12-24 |
JP2005001995A (ja) | 2005-01-06 |
US20040247559A1 (en) | 2004-12-09 |
CN1572292A (zh) | 2005-02-02 |
JP3806419B2 (ja) | 2006-08-09 |
DE602004018569D1 (de) | 2009-02-05 |
EP1486201A1 (en) | 2004-12-15 |
KR20040105601A (ko) | 2004-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Lee et al. | Biological activities of the polysaccharides produced from submerged culture of the edible Basidiomycete Grifola frondosa | |
RU2492850C2 (ru) | Средство для роста фибробластов | |
CN103565699B (zh) | 一种黑果枸杞祛斑美白抗衰老精华液及其制备方法 | |
CN108245479B (zh) | 一种含有乳双歧杆菌发酵活性提取物的面膜 | |
KR102085559B1 (ko) | 은이 버섯 추출물, 이의 제조방법 및 이의 용도 | |
CN107595737B (zh) | 含牛樟芝美白抗皱组合物及含该组合物的精华液及精华液的制备方法 | |
CN114209617B (zh) | 一种酵母发酵的灵芝提取物及其制备方法和用途 | |
CN1289062C (zh) | 化装料 | |
JP2016074647A (ja) | 保湿効果を有する乳酸菌米発酵物 | |
KR20130114808A (ko) | 콜라겐 천연 발효액을 포함하는 화장료 조성물 | |
CN109864910B (zh) | 一种具有抗衰老功能的虫草组合物及其制备方法和抗衰老护肤品 | |
JP5308542B2 (ja) | 微生物の胞子化に伴う母細胞分解酵素を利用した有機物の分解方法 | |
JP7466246B1 (ja) | シワ改善剤及びその製造方法 | |
JP2003073225A (ja) | 化粧料 | |
KR20030030488A (ko) | 잎새버섯 균사체의 추출물을 함유하는 피부 노화방지 효과및 미백효과를 갖는 화장료 조성물 | |
CN112516018B (zh) | 一种具有美白、抗衰、保湿、排毒功效的富硒绿豆发酵液及其面膜组合物 | |
EP1429716B1 (en) | Cosmetic preparation with anti-wrinkle action | |
CN111568799A (zh) | 一种海参酵解素在美白产品中的应用 | |
KR20170005534A (ko) | 천연배지를 이용한 잔나비걸상버섯 균사체 배양액을 함유하는 화장료 조성물 | |
JP2021127323A (ja) | HAS3 mRNA発現促進剤 | |
JP7349116B2 (ja) | 皮膚外用剤及び飲食品 | |
CN108904371A (zh) | 一种抗皱控油祛痘修复面膜及其制备方法 | |
CN117802010B (zh) | 发酵乳杆菌发酵滤液、其制备方法及其应用 | |
KR102542370B1 (ko) | 흑효모 유래의 엑소좀을 포함하는 화장료 조성물 | |
CN116687788B (zh) | 一种添加活性肽促进皮肤微生态平衡的复合物及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CX01 | Expiry of patent term |
Granted publication date: 20061213 |