CN1275963C - 制备二氮杂萘－3－羧酸衍生物的方法 - Google Patents

制备二氮杂萘－3－羧酸衍生物的方法 Download PDF

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Publication number
CN1275963C
CN1275963C CNB008123314A CN00812331A CN1275963C CN 1275963 C CN1275963 C CN 1275963C CN B008123314 A CNB008123314 A CN B008123314A CN 00812331 A CN00812331 A CN 00812331A CN 1275963 C CN1275963 C CN 1275963C
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CN
China
Prior art keywords
formula
compound
alkali
carboxylic acid
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB008123314A
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English (en)
Chinese (zh)
Other versions
CN1377350A (zh
Inventor
S·曹
H·蔡
J·D·海勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Corp
SB Pharmco Puerto Rico Inc
Original Assignee
LG Chem Investment Co Ltd
SB Pharmco Puerto Rico Inc
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Publication date
Application filed by LG Chem Investment Co Ltd, SB Pharmco Puerto Rico Inc filed Critical LG Chem Investment Co Ltd
Publication of CN1377350A publication Critical patent/CN1377350A/zh
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Publication of CN1275963C publication Critical patent/CN1275963C/zh
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB008123314A 1999-09-03 2000-09-01 制备二氮杂萘－3－羧酸衍生物的方法 Expired - Lifetime CN1275963C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9920917.3A GB9920917D0 (en) 1999-09-03 1999-09-03 Novel process
GB9920917.3 1999-09-03

Publications (2)

Publication Number Publication Date
CN1377350A CN1377350A (zh) 2002-10-30
CN1275963C true CN1275963C (zh) 2006-09-20

Family

ID=10860353

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008123314A Expired - Lifetime CN1275963C (zh) 1999-09-03 2000-09-01 制备二氮杂萘－3－羧酸衍生物的方法

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Country Link
US (1) US7232907B2 (enExample)
EP (1) EP1214321B1 (enExample)
JP (1) JP4208464B2 (enExample)
KR (1) KR100724311B1 (enExample)
CN (1) CN1275963C (enExample)
AR (1) AR029002A1 (enExample)
AT (1) ATE271050T1 (enExample)
AU (1) AU773722B2 (enExample)
BR (1) BRPI0013751B8 (enExample)
CA (1) CA2383753C (enExample)
CO (1) CO5470281A1 (enExample)
DE (1) DE60012196T2 (enExample)
DK (1) DK1214321T3 (enExample)
ES (1) ES2223574T3 (enExample)
GB (1) GB9920917D0 (enExample)
HK (1) HK1047093B (enExample)
MX (1) MXPA02002355A (enExample)
MY (1) MY125309A (enExample)
PT (1) PT1214321E (enExample)
SI (1) SI1214321T1 (enExample)
TW (1) TWI274753B (enExample)
WO (1) WO2001018002A1 (enExample)
ZA (1) ZA200201781B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2281817C (en) * 1999-06-29 2008-07-29 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
WO2003011450A1 (en) 2001-08-02 2003-02-13 Lg Life Sciences Limited Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof
KR100517638B1 (ko) * 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
KR100653334B1 (ko) * 2003-03-07 2006-12-04 주식회사 엘지생명과학 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법
WO2006134431A1 (en) * 2005-05-03 2006-12-21 Ranbaxy Laboratories Limited Formate salt of gemifloxacin
EP2159225A1 (en) 2005-06-15 2010-03-03 Hetero Drugs Limited Gemifloxacin process and polymorphs
US20100076193A1 (en) * 2006-10-31 2010-03-25 Chandrasekaran Ramasubbu process for the preparation of gemifloxacin

Family Cites Families (27)

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JPS57134482A (en) 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (enExample) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja) 1987-10-13 1989-04-18 Shionogi & Co Ltd オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
JPH0356479A (ja) 1989-07-24 1991-03-12 Takeshi Yokota 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
IE66202B1 (en) 1989-08-16 1995-12-13 Pfizer Azabicyclo quinolone carboxylic acids
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
EP0541086A1 (en) 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
JPH0673056A (ja) 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
US5776944A (en) * 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
JP3449658B2 (ja) 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
CA2223404C (en) 1995-06-06 2001-01-16 Thomas A. Morris Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt
RU2140910C1 (ru) 1995-08-11 1999-11-10 Пфайзер Инк. Тригидрат метансульфоната (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4- фенилпиперидин-1-ил)-1-пропанола
BR9708336A (pt) 1996-03-29 1999-08-03 Smithkline Beecham Corp Diidrato de eprosartan e processo para sua produção e formulação
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
KR100286874B1 (ko) * 1998-03-04 2001-04-16 성재갑 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
JP2002516308A (ja) 1998-05-29 2002-06-04 ファルマシア・アンド・アップジョン・カンパニー ３−［（１’−ｎ−メチルアミノ）エチル−ｎ−ベンジル］ピロリジンモノメタンスルホネート
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
PT1223935E (pt) 1999-06-29 2008-04-03 Lg Life Sciences Ltd Utilização de compostos de gemifloxacina contra bactérias
AU6947900A (en) 1999-09-01 2001-03-26 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
AU7709400A (en) 1999-09-22 2001-04-24 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
KR20010091379A (ko) 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko) 2000-09-01 2002-03-08 성재갑 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

Also Published As

Publication number Publication date
MXPA02002355A (es) 2004-07-16
GB9920917D0 (en) 1999-11-10
CA2383753A1 (en) 2001-03-15
KR100724311B1 (ko) 2007-06-04
TWI274753B (en) 2007-03-01
DK1214321T3 (da) 2004-10-25
CN1377350A (zh) 2002-10-30
ATE271050T1 (de) 2004-07-15
AU773722B2 (en) 2004-06-03
EP1214321A1 (en) 2002-06-19
CA2383753C (en) 2011-06-28
PT1214321E (pt) 2004-10-29
ES2223574T3 (es) 2005-03-01
EP1214321B1 (en) 2004-07-14
HK1047093A1 (en) 2003-02-07
JP2003508532A (ja) 2003-03-04
JP4208464B2 (ja) 2009-01-14
DE60012196T2 (de) 2005-08-18
ZA200201781B (en) 2003-06-25
BR0013751A (pt) 2002-05-07
KR20020041421A (ko) 2002-06-01
SI1214321T1 (en) 2004-12-31
US7232907B2 (en) 2007-06-19
US20050176961A1 (en) 2005-08-11
HK1047093B (en) 2005-05-27
BR0013751B1 (pt) 2013-02-05
CO5470281A1 (es) 2004-12-30
AU7019700A (en) 2001-04-10
WO2001018002A1 (en) 2001-03-15
DE60012196D1 (de) 2004-08-19
BRPI0013751B8 (pt) 2021-05-25
AR029002A1 (es) 2003-06-04
MY125309A (en) 2006-07-31

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