CN1264819C - 前列环素衍生物的立体选择合成方法 - Google Patents

前列环素衍生物的立体选择合成方法 Download PDF

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Publication number
CN1264819C
CN1264819C CNB988126397A CN98812639A CN1264819C CN 1264819 C CN1264819 C CN 1264819C CN B988126397 A CNB988126397 A CN B988126397A CN 98812639 A CN98812639 A CN 98812639A CN 1264819 C CN1264819 C CN 1264819C
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CN
China
Prior art keywords
fluorine
alkyl
group
condition
methyl
Prior art date
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Expired - Lifetime
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CNB988126397A
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English (en)
Chinese (zh)
Other versions
CN1283184A (zh
Inventor
R·M·莫里尔蒂
R·彭马斯塔
L·郭
M·S·劳
J·P·斯塔舍夫斯基
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United Therapeutics Corp
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United Therapeutics Corp
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Publication of CN1283184A publication Critical patent/CN1283184A/zh
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Publication of CN1264819C publication Critical patent/CN1264819C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
CNB988126397A 1997-10-24 1998-10-26 前列环素衍生物的立体选择合成方法 Expired - Lifetime CN1264819C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95773697A 1997-10-24 1997-10-24
US08/957,736 1997-10-24

Publications (2)

Publication Number Publication Date
CN1283184A CN1283184A (zh) 2001-02-07
CN1264819C true CN1264819C (zh) 2006-07-19

Family

ID=25500067

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988126397A Expired - Lifetime CN1264819C (zh) 1997-10-24 1998-10-26 前列环素衍生物的立体选择合成方法

Country Status (11)

Country Link
EP (1) EP1025083B1 (https=)
JP (1) JP3717053B2 (https=)
KR (1) KR100447022B1 (https=)
CN (1) CN1264819C (https=)
AT (1) ATE245628T1 (https=)
CA (2) CA2307163C (https=)
DE (1) DE69816642T2 (https=)
DK (1) DK1025083T3 (https=)
ES (1) ES2198760T3 (https=)
PT (1) PT1025083E (https=)
WO (1) WO1999021830A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
ES2622471T5 (es) 2003-05-22 2020-07-23 United Therapeutics Corp Compuestos y procedimientos para la administración de análogos de prostaciclina
CN103181893A (zh) 2007-09-07 2013-07-03 联合治疗公司 针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法
CN101903324B (zh) 2007-12-17 2013-07-03 联合治疗公司 一种制备Remodulin中的活性成分曲前列素的改良方法
CN101891596B (zh) * 2009-05-22 2013-12-11 上海天伟生物制药有限公司 一种化合物及其制备方法和用途
JP6046034B2 (ja) 2010-06-03 2016-12-14 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの製造
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
US20130345471A1 (en) * 2011-03-02 2013-12-26 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
US8524939B2 (en) * 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN103193627B (zh) * 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193626B (zh) * 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
JP2016517410A (ja) 2013-03-14 2016-06-16 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの固体形態
HU231186B1 (hu) 2014-10-08 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás treprostinil és sói előállítására
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
DE19708496A1 (de) * 1997-03-03 1998-09-10 Hoechst Ag Verfahren zur enantionmerenreinen Anthracylin-Synthese

Also Published As

Publication number Publication date
CA2307163C (en) 2014-05-06
DK1025083T3 (da) 2004-03-01
CN1283184A (zh) 2001-02-07
PT1025083E (pt) 2003-10-31
CA2847985A1 (en) 1999-05-06
EP1025083A1 (en) 2000-08-09
ES2198760T3 (es) 2004-02-01
DE69816642T2 (de) 2004-06-09
WO1999021830A8 (en) 1999-07-22
CA2307163A1 (en) 1999-05-06
EP1025083B1 (en) 2003-07-23
DE69816642D1 (de) 2003-08-28
ATE245628T1 (de) 2003-08-15
CA2847985C (en) 2015-02-03
WO1999021830A1 (en) 1999-05-06
JP3717053B2 (ja) 2005-11-16
JP2004500303A (ja) 2004-01-08
KR100447022B1 (ko) 2004-09-07
KR20010031309A (ko) 2001-04-16

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Granted publication date: 20060719