CN1261812A - 用于向组织中体内进行核酸载体最佳电转移的装置 - Google Patents

用于向组织中体内进行核酸载体最佳电转移的装置 Download PDF

Info

Publication number
CN1261812A
CN1261812A CN98806793A CN98806793A CN1261812A CN 1261812 A CN1261812 A CN 1261812A CN 98806793 A CN98806793 A CN 98806793A CN 98806793 A CN98806793 A CN 98806793A CN 1261812 A CN1261812 A CN 1261812A
Authority
CN
China
Prior art keywords
electrode
pulse
electrotransfer
nucleic acid
electric field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98806793A
Other languages
English (en)
Chinese (zh)
Inventor
M·布瑞奥
L·密尔
D·舍曼
B·施瓦茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Gustave Roussy (IGR)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Institut Gustave Roussy (IGR)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9708233A external-priority patent/FR2765242B1/fr
Priority claimed from FR9708232A external-priority patent/FR2765241B1/fr
Application filed by Rhone Poulenc Rorer SA, Institut Gustave Roussy (IGR) filed Critical Rhone Poulenc Rorer SA
Publication of CN1261812A publication Critical patent/CN1261812A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN98806793A 1997-06-30 1998-06-30 用于向组织中体内进行核酸载体最佳电转移的装置 Pending CN1261812A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
FR97/08233 1997-06-30
FR9708233A FR2765242B1 (fr) 1997-06-30 1997-06-30 Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
FR97/08232 1997-06-30
FR9708232A FR2765241B1 (fr) 1997-06-30 1997-06-30 Amelioration du transfert d'acide nucleique dans les cellules d'organismes eucaryotes pluricellulaires et combinaison permettant la mise en oeuvre du procede
US6748797P 1997-12-01 1997-12-01
US6748897P 1997-12-01 1997-12-01
US60/067,488 1997-12-01
US60/067,487 1997-12-01
US8385898P 1998-05-01 1998-05-01
US60/083,858 1998-05-01

Publications (1)

Publication Number Publication Date
CN1261812A true CN1261812A (zh) 2000-08-02

Family

ID=27515625

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98806793A Pending CN1261812A (zh) 1997-06-30 1998-06-30 用于向组织中体内进行核酸载体最佳电转移的装置

Country Status (11)

Country Link
EP (1) EP0993318A1 (no)
JP (1) JP2002515816A (no)
KR (1) KR20010014298A (no)
CN (1) CN1261812A (no)
AU (1) AU8730798A (no)
BR (1) BR9810500A (no)
CA (1) CA2295029A1 (no)
IL (1) IL133709A0 (no)
NO (1) NO996540L (no)
PL (1) PL337617A1 (no)
WO (1) WO1999001175A1 (no)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101252953A (zh) * 2005-09-02 2008-08-27 生物联盟制药公司 核酸向组织细胞中的电转移
US8414133B2 (en) 2007-03-06 2013-04-09 Sanyo Electric Co., Ltd. Projection display device having an operation section for displacing a lens
CN112402798A (zh) * 2005-10-03 2021-02-26 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753379B1 (fr) 1996-09-13 1998-10-30 Rhone Poulenc Rorer Sa Methode de traitement de la sclerose laterale amyotrophique
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
CA2361601A1 (en) * 1999-02-08 2000-08-10 Cheryl Goldbeck Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
WO2001068131A1 (en) 2000-03-13 2001-09-20 Cornell Research Foundation, Inc. Blocking leukocyte emigration and inflammation by interfering with cd99/hec2
JP2003531149A (ja) 2000-04-13 2003-10-21 ザ・ロツクフエラー・ユニバーシテイ 抗体由来の免疫応答の増強
JP2004532654A (ja) 2000-05-22 2004-10-28 マーク・アンド・カンパニー・インコーポレイテッド 薬剤投与システム性能評価システム及び方法
CN100422210C (zh) 2000-12-28 2008-10-01 Wyeth公司 来自肺炎链球菌的重组防护蛋白质
JP2005508134A (ja) 2001-03-02 2005-03-31 ザ ロックフェラー ユニヴァーシティ 天然アレルゲンの免疫原性を保持する、アレルゲン性が低下した組み換えハイブリッドアレルゲン構築体
US20020198567A1 (en) * 2001-06-07 2002-12-26 Yona Keisari Electro-endocytotic therapy as a treatment modality of cancer
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
US20050154434A1 (en) 2002-03-07 2005-07-14 Adam Simon Clinical syringe with electrical stimulation aspects
US7217796B2 (en) 2002-05-24 2007-05-15 Schering Corporation Neutralizing human anti-IGFR antibody
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
JP4961137B2 (ja) * 2005-12-14 2012-06-27 久光製薬株式会社 イオントフォレーシス用デバイス
WO2008060814A2 (en) 2006-10-19 2008-05-22 Merck & Co., Inc. ANTI-IL-13Rα1 ANTIBODIES AND THEIR USES THEREOF
DK2068921T3 (da) 2006-10-19 2014-09-15 Csl Ltd Antistof-antagonister med høj affinitet af interleukin-13-receptor alpha 1
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
US8093043B2 (en) 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
EP2310500B1 (en) * 2008-07-18 2015-03-11 Maxcyte, Inc. Methods for optimizing electroporation
MX2011004755A (es) 2008-11-05 2011-10-10 Wyeth Llc Composicion inmunogenica multicomponente para la prevencion de enfermedad estreptococica beta-hemolitica (bhs).
KR101594228B1 (ko) 2010-08-23 2016-02-15 와이어쓰 엘엘씨 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
KR101763625B1 (ko) 2012-03-09 2017-08-01 화이자 인코포레이티드 수막염균 조성물 및 이의 사용 방법
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
WO2014107739A1 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Antibodies against pcsk9
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
US9822150B2 (en) 2013-09-08 2017-11-21 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
KR20170103009A (ko) 2015-02-19 2017-09-12 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
PE20191107A1 (es) 2017-01-31 2019-08-26 Pfizer Composiciones de neisseria meningitidis y metodos respectivos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317380D0 (en) * 1993-08-20 1993-10-06 Therexsys Ltd Transfection process
US5641680A (en) * 1994-11-14 1997-06-24 Zhao; Xi Gene transfer apparatus and method for using the same
WO1997007826A1 (en) * 1995-08-29 1997-03-06 Cbr Laboratories, Inc. In vivo electroporation of cells

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101252953A (zh) * 2005-09-02 2008-08-27 生物联盟制药公司 核酸向组织细胞中的电转移
CN112402798A (zh) * 2005-10-03 2021-02-26 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
CN112402798B (zh) * 2005-10-03 2021-11-16 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US8414133B2 (en) 2007-03-06 2013-04-09 Sanyo Electric Co., Ltd. Projection display device having an operation section for displacing a lens

Also Published As

Publication number Publication date
IL133709A0 (en) 2001-04-30
EP0993318A1 (en) 2000-04-19
PL337617A1 (en) 2000-08-28
NO996540D0 (no) 1999-12-29
BR9810500A (pt) 2000-09-05
JP2002515816A (ja) 2002-05-28
AU8730798A (en) 1999-01-25
NO996540L (no) 2000-02-03
CA2295029A1 (en) 1999-01-14
WO1999001175A1 (en) 1999-01-14
KR20010014298A (ko) 2001-02-26

Similar Documents

Publication Publication Date Title
CN1261812A (zh) 用于向组织中体内进行核酸载体最佳电转移的装置
CN1261807A (zh) 向横纹肌中转移核酸的改进方法和用于实施该方法的组合
CN1261808A (zh) 向多细胞真核生物的细胞中转移核酸的改进方法和用于实施该方法的组合
Rols et al. In vivo electrically mediated protein and gene transfer in murine melanoma
Vicat et al. Brief report: muscle transfection by electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression
Potter et al. Transfection by electroporation
Reed et al. Electroporation advances in large animals
Connolly et al. Plasma facilitated delivery of DNA to skin
Lundin et al. 150. Cooperative Strand Invasion of Super-Coiled Plasmid DNA by Mixed Linear PNA and PNA-Peptide Chimeras
CN1703257A (zh) 心脏刺激系统和方法
AU2014343808B2 (en) Gene electrotransfer into skin cells
Rossini et al. High level of gene transfer into adult skeletal muscle by in vivo direct electroporation
Šatkauskas et al. ELECTROPORATION AS A TOOL FOR BIOTECHNOLOGY AND MEDICINE WITH SPECIFIC EMPHASIZE ON ITS APPLICATION FOR DRUG AND GENE DELIVERY.
AU4576202A (en) Improvement in the transfer of nucleic acid into the cells of pluricellular eukaryotic organisms and combination allowing the method to be carried out
MXPA99011527A (en) Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo
US20160038577A1 (en) Use of anti-erbb2 vaccines in association with an electric field
KR20030068337A (ko) 유전자치료용 진핵발현벡터
MXPA99011444A (es) Metodo mejorado de transferencia de acidos nucleicos enmusculo estraido y combinaciones que permienn el uso del procedimiento
AU4439102A (en) Improved method for transferring nucleic acid into the striped muscle and combination therefor
CZ475699A3 (cs) Systém a zařízení pro in vivo přenos nukleových kyselin do tkání

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication