CN1259135A - 9－肟红霉素衍生物 - Google Patents

9－肟红霉素衍生物 Download PDF

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Publication number
CN1259135A
CN1259135A CN98805848A CN98805848A CN1259135A CN 1259135 A CN1259135 A CN 1259135A CN 98805848 A CN98805848 A CN 98805848A CN 98805848 A CN98805848 A CN 98805848A CN 1259135 A CN1259135 A CN 1259135A
Authority
CN
China
Prior art keywords
deoxy
methyl
oxo
desosaminyl
chek
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98805848A
Other languages
English (en)
Chinese (zh)
Inventor
邬永金
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1259135A publication Critical patent/CN1259135A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN98805848A 1997-06-11 1998-05-15 9－肟红霉素衍生物 Pending CN1259135A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934997P 1997-06-11 1997-06-11
US60/049,349 1997-06-11

Publications (1)

Publication Number Publication Date
CN1259135A true CN1259135A (zh) 2000-07-05

Family

ID=21959341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98805848A Pending CN1259135A (zh) 1997-06-11 1998-05-15 9－肟红霉素衍生物

Country Status (31)

Country Link
EP (1) EP0988308A1 (tr)
JP (1) JP2000513026A (tr)
KR (1) KR20010013660A (tr)
CN (1) CN1259135A (tr)
AP (1) AP9801253A0 (tr)
AR (1) AR012244A1 (tr)
AU (1) AU7226798A (tr)
BG (1) BG103947A (tr)
BR (1) BR9810021A (tr)
CA (1) CA2293335A1 (tr)
CO (1) CO4940506A1 (tr)
CZ (1) CZ9904388A3 (tr)
EA (1) EA199901016A1 (tr)
GT (1) GT199800074A (tr)
HN (1) HN1998000073A (tr)
HR (1) HRP980316A2 (tr)
HU (1) HUP0002252A3 (tr)
ID (1) ID24529A (tr)
IL (1) IL132767A0 (tr)
IS (1) IS5251A (tr)
MA (1) MA26505A1 (tr)
NO (1) NO996108L (tr)
OA (1) OA11225A (tr)
PA (1) PA8451801A1 (tr)
PE (1) PE79899A1 (tr)
PL (1) PL337606A1 (tr)
TN (1) TNSN98083A1 (tr)
TR (1) TR199902995T2 (tr)
TW (1) TW448174B (tr)
WO (1) WO1998056800A1 (tr)
ZA (1) ZA985018B (tr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
WO2000017218A1 (en) * 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
US6258785B1 (en) 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) * 1998-12-18 2001-09-04 Bio-Rad Laboratories, Inc. Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
KR20020007374A (ko) * 1999-04-16 2002-01-26 추후제출 매크롤라이드 항감염제
WO2000071557A1 (en) 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
JP2003501439A (ja) * 1999-06-07 2003-01-14 アボット・ラボラトリーズ ６−ｏ−カルバメートケトライド誘導体
ID27331A (id) * 1999-09-29 2001-03-29 Pfizer Prod Inc Pembuatan antibiotik-antibiotik ketolida karbamat
EP1439186A3 (en) * 1999-12-29 2004-11-03 Pfizer Products Inc. Intermediates for novel antibacterial and prokinetic macrolides
EP1114826A3 (en) * 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) * 2002-04-25 2003-11-06 Abbott Laboratories 9-oxime macrolide antibacterials
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2010048601A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CN102146085B (zh) * 2010-02-09 2014-03-26 北京理工大学 一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
SI2550286T1 (sl) 2010-03-22 2016-04-29 Cempra Pharmaceuticals, Inc. Kristalne oblike makrolida in njihove uporabe
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
RU2658050C2 (ru) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Парентеральные составы для введения макролидных антибиотиков
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
HUP0002252A2 (hu) 2000-12-28
IS5251A (is) 1999-11-16
BG103947A (en) 2000-07-31
IL132767A0 (en) 2001-03-19
AR012244A1 (es) 2000-09-27
TR199902995T2 (tr) 2000-02-21
GT199800074A (es) 1999-11-27
CO4940506A1 (es) 2000-07-24
ZA985018B (en) 1999-12-10
TW448174B (en) 2001-08-01
MA26505A1 (fr) 2004-12-20
EP0988308A1 (en) 2000-03-29
CA2293335A1 (en) 1998-12-17
EA199901016A1 (ru) 2000-06-26
PL337606A1 (en) 2000-08-28
HN1998000073A (es) 1999-01-08
ID24529A (id) 2000-07-20
HRP980316A2 (en) 1999-04-30
KR20010013660A (ko) 2001-02-26
AU7226798A (en) 1998-12-30
HUP0002252A3 (en) 2002-01-28
JP2000513026A (ja) 2000-10-03
TNSN98083A1 (fr) 2005-03-15
OA11225A (en) 2003-07-17
PE79899A1 (es) 1999-08-25
CZ9904388A3 (cs) 2002-10-16
BR9810021A (pt) 2000-09-19
NO996108D0 (no) 1999-12-10
AP9801253A0 (en) 1999-12-04
PA8451801A1 (es) 2000-05-24
NO996108L (no) 2000-02-10
WO1998056800A1 (en) 1998-12-17

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