CN1244593C - 氟米松及其17－羧基雄甾烯类似物的制备 - Google Patents

氟米松及其17－羧基雄甾烯类似物的制备 Download PDF

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Publication number
CN1244593C
CN1244593C CNB028117662A CN02811766A CN1244593C CN 1244593 C CN1244593 C CN 1244593C CN B028117662 A CNB028117662 A CN B028117662A CN 02811766 A CN02811766 A CN 02811766A CN 1244593 C CN1244593 C CN 1244593C
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CN
China
Prior art keywords
compound
formula
reaction
fluorine
flumethasone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028117662A
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English (en)
Chinese (zh)
Other versions
CN1531544A (zh
Inventor
伊万·维拉什
齐塔·门德斯
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HOVIONE Ltd
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HOVIONE Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20086054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1244593(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by HOVIONE Ltd filed Critical HOVIONE Ltd
Publication of CN1531544A publication Critical patent/CN1531544A/zh
Application granted granted Critical
Publication of CN1244593C publication Critical patent/CN1244593C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Control Of Combustion (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
CNB028117662A 2001-06-12 2002-06-11 氟米松及其17－羧基雄甾烯类似物的制备 Expired - Fee Related CN1244593C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT102.628 2001-06-12
PT102628A PT102628B (pt) 2001-06-12 2001-06-12 Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno

Publications (2)

Publication Number Publication Date
CN1531544A CN1531544A (zh) 2004-09-22
CN1244593C true CN1244593C (zh) 2006-03-08

Family

ID=20086054

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028117662A Expired - Fee Related CN1244593C (zh) 2001-06-12 2002-06-11 氟米松及其17－羧基雄甾烯类似物的制备

Country Status (19)

Country Link
US (1) US6528666B1 (enExample)
EP (1) EP1395603B1 (enExample)
JP (1) JP4095018B2 (enExample)
CN (1) CN1244593C (enExample)
AT (1) ATE460422T1 (enExample)
AU (1) AU2002310616B2 (enExample)
CA (1) CA2450661C (enExample)
CY (1) CY1109960T1 (enExample)
DE (1) DE60235625D1 (enExample)
DK (1) DK1395603T3 (enExample)
ES (1) ES2338768T3 (enExample)
IL (2) IL159343A0 (enExample)
NO (1) NO326153B1 (enExample)
NZ (1) NZ530536A (enExample)
PL (1) PL206731B1 (enExample)
PT (1) PT102628B (enExample)
RU (1) RU2260596C1 (enExample)
WO (1) WO2002100878A1 (enExample)
ZA (1) ZA200309656B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101942002A (zh) * 2010-09-24 2011-01-12 岳阳环宇药业有限公司 一种甾体21位酯化物的精制工艺

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098328B2 (en) 2001-11-29 2006-08-29 Taro Pharmaceutical Industries Limited Method for the preparation of 6α-fluoro corticosteroids
WO2004052911A1 (en) * 2002-12-09 2004-06-24 Sicor Inc. Process for the preparation of pregnanes
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法
CN101759761B (zh) * 2008-11-28 2012-08-08 天津金耀集团有限公司 含有6α-F的甾体化合物的制备方法
CN102272304B (zh) 2009-01-07 2013-10-23 三菱化学株式会社 切断固醇侧链的酶蛋白质及其应用
ITMI20122200A1 (it) 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani
RU2532902C1 (ru) * 2013-07-12 2014-11-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Способ получения 11бета, 17альфа, 21-тригидрокси-16альфа-метил-9альфа-фторпрегна-1,4-диен-3,20-диона (дексаметазона) из фитостерина

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499016A (en) 1958-08-04 1970-03-03 Upjohn Co 6alpha-fluoro-16alpha-methyl derivatives of the pregnane series
US3636010A (en) 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
FR2701262B1 (fr) 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101942002A (zh) * 2010-09-24 2011-01-12 岳阳环宇药业有限公司 一种甾体21位酯化物的精制工艺

Also Published As

Publication number Publication date
US6528666B1 (en) 2003-03-04
CN1531544A (zh) 2004-09-22
PT102628A (pt) 2002-12-31
PT102628B (pt) 2010-09-09
NO20035517D0 (no) 2003-12-11
CA2450661A1 (en) 2002-12-19
DE60235625D1 (de) 2010-04-22
WO2002100878A1 (en) 2002-12-19
EP1395603A1 (en) 2004-03-10
ATE460422T1 (de) 2010-03-15
JP2004534795A (ja) 2004-11-18
AU2002310616B2 (en) 2007-08-30
IL159343A (en) 2010-11-30
CA2450661C (en) 2008-01-08
JP4095018B2 (ja) 2008-06-04
EP1395603B1 (en) 2010-03-10
PL206731B1 (pl) 2010-09-30
ZA200309656B (en) 2004-06-22
NZ530536A (en) 2005-05-27
NO326153B1 (no) 2008-10-06
ES2338768T3 (es) 2010-05-12
AU2002310616A2 (en) 2002-12-23
CY1109960T1 (el) 2014-09-10
RU2260596C1 (ru) 2005-09-20
IL159343A0 (en) 2004-06-01
RU2004100309A (ru) 2005-07-10
PL367843A1 (en) 2005-03-07
DK1395603T3 (da) 2010-05-10

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Granted publication date: 20060308

Termination date: 20200611

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