CN1241549C - 两性脂质体及其应用 - Google Patents

两性脂质体及其应用 Download PDF

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Publication number
CN1241549C
CN1241549C CNB028052137A CN02805213A CN1241549C CN 1241549 C CN1241549 C CN 1241549C CN B028052137 A CNB028052137 A CN B028052137A CN 02805213 A CN02805213 A CN 02805213A CN 1241549 C CN1241549 C CN 1241549C
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China
Prior art keywords
liposome
liposomes
amphoteric lipid
lipid body
amphoteric
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN1492756A (zh
Inventor
斯特芬·潘茨纳
斯特凡·范克豪尼尔
弗朗克·埃斯勒
科妮莉亚·潘茨纳
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Marina Biotech Inc
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Novosom AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028052137A 2001-02-21 2002-02-21 两性脂质体及其应用 Expired - Fee Related CN1241549C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10109897.9 2001-02-21
DE10109897A DE10109897A1 (de) 2001-02-21 2001-02-21 Fakultativ kationische Liposomen und Verwendung dieser

Publications (2)

Publication Number Publication Date
CN1492756A CN1492756A (zh) 2004-04-28
CN1241549C true CN1241549C (zh) 2006-02-15

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CNB028052137A Expired - Fee Related CN1241549C (zh) 2001-02-21 2002-02-21 两性脂质体及其应用

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US (4) US7371404B2 (https=)
EP (1) EP1363601B1 (https=)
JP (5) JP2004525898A (https=)
CN (1) CN1241549C (https=)
AT (1) ATE363893T1 (https=)
AU (1) AU2002234643B2 (https=)
BR (1) BRPI0207775B1 (https=)
CA (1) CA2438116C (https=)
DE (2) DE10109897A1 (https=)
ES (1) ES2289079T3 (https=)
WO (1) WO2002066012A2 (https=)

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CA2438116C (en) 2011-10-11
US20070252295A1 (en) 2007-11-01
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US20030099697A1 (en) 2003-05-29
US20110293695A1 (en) 2011-12-01
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CA2438116A1 (en) 2002-08-29
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US7780983B2 (en) 2010-08-24
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