CN1239498C - 作为ccr－3受体拮抗剂的取代的吡咯烷 - Google Patents

作为ccr－3受体拮抗剂的取代的吡咯烷 Download PDF

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Publication number
CN1239498C
CN1239498C CNB018208789A CN01820878A CN1239498C CN 1239498 C CN1239498 C CN 1239498C CN B018208789 A CNB018208789 A CN B018208789A CN 01820878 A CN01820878 A CN 01820878A CN 1239498 C CN1239498 C CN 1239498C
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CN
China
Prior art keywords
formula
compound
alkyl
alk
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018208789A
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English (en)
Chinese (zh)
Other versions
CN1481379A (zh
Inventor
丹尼斯·约翰·凯尔泰斯
米歇尔·加勒特·勒佩尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1481379A publication Critical patent/CN1481379A/zh
Application granted granted Critical
Publication of CN1239498C publication Critical patent/CN1239498C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB018208789A 2000-12-19 2001-12-13 作为ccr－3受体拮抗剂的取代的吡咯烷 Expired - Fee Related CN1239498C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25658500P 2000-12-19 2000-12-19
US60/256,585 2000-12-19

Publications (2)

Publication Number Publication Date
CN1481379A CN1481379A (zh) 2004-03-10
CN1239498C true CN1239498C (zh) 2006-02-01

Family

ID=22972794

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018208789A Expired - Fee Related CN1239498C (zh) 2000-12-19 2001-12-13 作为ccr－3受体拮抗剂的取代的吡咯烷

Country Status (15)

Country Link
US (2) US6552028B2 (cg-RX-API-DMAC7.html)
EP (1) EP1358181B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004519443A (cg-RX-API-DMAC7.html)
KR (1) KR20030061455A (cg-RX-API-DMAC7.html)
CN (1) CN1239498C (cg-RX-API-DMAC7.html)
AR (1) AR035519A1 (cg-RX-API-DMAC7.html)
AT (1) ATE374198T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002216107A1 (cg-RX-API-DMAC7.html)
BR (1) BR0116352A (cg-RX-API-DMAC7.html)
CA (1) CA2431767A1 (cg-RX-API-DMAC7.html)
DE (1) DE60130684T2 (cg-RX-API-DMAC7.html)
ES (1) ES2292530T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA03005581A (cg-RX-API-DMAC7.html)
WO (1) WO2002050064A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200304530B (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1680408A2 (en) * 2003-10-24 2006-07-19 F. Hoffmann-La Roche Ag Ccr3 receptor antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
ATE386720T1 (de) * 1998-11-20 2008-03-15 Hoffmann La Roche Piperidin ccr-3 rezeptor-hemmer
BR9915520A (pt) * 1998-11-20 2001-07-17 Hoffmann La Roche Antagonistas receptores ccr-3 derivados de pirrolidina
HK1044282A1 (zh) 1998-12-18 2002-10-18 Bristol-Myers Squibb Pharma Company 作为趋化因子受体活性调节剂的n-脲基烷基-哌啶化合物
US6331545B1 (en) 1998-12-18 2001-12-18 Soo S. Ko Heterocycyclic piperidines as modulators of chemokine receptor activity
AU2057200A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU3126700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2482100A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2347909A1 (en) 1998-12-18 2000-06-22 Joseph B. Santella, Iii N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1140833A1 (en) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
ZA200304530B (en) 2004-09-10
EP1358181A1 (en) 2003-11-05
WO2002050064A1 (en) 2002-06-27
CA2431767A1 (en) 2002-06-27
DE60130684T2 (de) 2008-08-14
KR20030061455A (ko) 2003-07-18
EP1358181B1 (en) 2007-09-26
AR035519A1 (es) 2004-06-02
ES2292530T3 (es) 2008-03-16
US20030199532A1 (en) 2003-10-23
US6552028B2 (en) 2003-04-22
DE60130684D1 (de) 2007-11-08
ATE374198T1 (de) 2007-10-15
MXPA03005581A (es) 2003-10-06
BR0116352A (pt) 2003-12-02
JP2004519443A (ja) 2004-07-02
AU2002216107A1 (en) 2002-07-01
CN1481379A (zh) 2004-03-10
US20020198255A1 (en) 2002-12-26

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