AR035519A1 - Derivados de pirrolidina 2,4-substituidos, antagonistas del receptor ccr-3 - Google Patents
Derivados de pirrolidina 2,4-substituidos, antagonistas del receptor ccr-3Info
- Publication number
- AR035519A1 AR035519A1 ARP010105833A ARP010105833A AR035519A1 AR 035519 A1 AR035519 A1 AR 035519A1 AR P010105833 A ARP010105833 A AR P010105833A AR P010105833 A ARP010105833 A AR P010105833A AR 035519 A1 AR035519 A1 AR 035519A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- group
- heteroalkyl
- aryl
- Prior art date
Links
- 101710149862 C-C chemokine receptor type 3 Chemical class 0.000 title 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 150000002431 hydrogen Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 102000004499 CCR3 Receptors Human genes 0.000 abstract 2
- 108010017316 CCR3 Receptors Proteins 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000002464 receptor antagonist Substances 0.000 abstract 2
- 229940044551 receptor antagonist Drugs 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25658500P | 2000-12-19 | 2000-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035519A1 true AR035519A1 (es) | 2004-06-02 |
Family
ID=22972794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105833A AR035519A1 (es) | 2000-12-19 | 2001-12-17 | Derivados de pirrolidina 2,4-substituidos, antagonistas del receptor ccr-3 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6552028B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1358181B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2004519443A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20030061455A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1239498C (cg-RX-API-DMAC7.html) |
| AR (1) | AR035519A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE374198T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002216107A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0116352A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2431767A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60130684T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2292530T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03005581A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002050064A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200304530B (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1680408A2 (en) * | 2003-10-24 | 2006-07-19 | F. Hoffmann-La Roche Ag | Ccr3 receptor antagonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| ATE386720T1 (de) * | 1998-11-20 | 2008-03-15 | Hoffmann La Roche | Piperidin ccr-3 rezeptor-hemmer |
| BR9915520A (pt) * | 1998-11-20 | 2001-07-17 | Hoffmann La Roche | Antagonistas receptores ccr-3 derivados de pirrolidina |
| HK1044282A1 (zh) | 1998-12-18 | 2002-10-18 | Bristol-Myers Squibb Pharma Company | 作为趋化因子受体活性调节剂的n-脲基烷基-哌啶化合物 |
| US6331545B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | Heterocycyclic piperidines as modulators of chemokine receptor activity |
| AU2057200A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| AU2482100A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| CA2347909A1 (en) | 1998-12-18 | 2000-06-22 | Joseph B. Santella, Iii | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| EP1140833A1 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
-
2001
- 2001-12-13 AU AU2002216107A patent/AU2002216107A1/en not_active Abandoned
- 2001-12-13 AT AT01271370T patent/ATE374198T1/de not_active IP Right Cessation
- 2001-12-13 DE DE60130684T patent/DE60130684T2/de not_active Expired - Fee Related
- 2001-12-13 ES ES01271370T patent/ES2292530T3/es not_active Expired - Lifetime
- 2001-12-13 EP EP01271370A patent/EP1358181B1/en not_active Expired - Lifetime
- 2001-12-13 CN CNB018208789A patent/CN1239498C/zh not_active Expired - Fee Related
- 2001-12-13 MX MXPA03005581A patent/MXPA03005581A/es active IP Right Grant
- 2001-12-13 JP JP2002551560A patent/JP2004519443A/ja active Pending
- 2001-12-13 KR KR10-2003-7008134A patent/KR20030061455A/ko not_active Ceased
- 2001-12-13 CA CA002431767A patent/CA2431767A1/en not_active Abandoned
- 2001-12-13 WO PCT/EP2001/014670 patent/WO2002050064A1/en not_active Ceased
- 2001-12-13 BR BR0116352-3A patent/BR0116352A/pt not_active IP Right Cessation
- 2001-12-17 AR ARP010105833A patent/AR035519A1/es not_active Application Discontinuation
- 2001-12-19 US US10/034,034 patent/US6552028B2/en not_active Expired - Fee Related
-
2003
- 2003-02-18 US US10/368,097 patent/US20030199532A1/en not_active Abandoned
- 2003-06-10 ZA ZA200304530A patent/ZA200304530B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200304530B (en) | 2004-09-10 |
| EP1358181A1 (en) | 2003-11-05 |
| WO2002050064A1 (en) | 2002-06-27 |
| CA2431767A1 (en) | 2002-06-27 |
| DE60130684T2 (de) | 2008-08-14 |
| KR20030061455A (ko) | 2003-07-18 |
| EP1358181B1 (en) | 2007-09-26 |
| CN1239498C (zh) | 2006-02-01 |
| ES2292530T3 (es) | 2008-03-16 |
| US20030199532A1 (en) | 2003-10-23 |
| US6552028B2 (en) | 2003-04-22 |
| DE60130684D1 (de) | 2007-11-08 |
| ATE374198T1 (de) | 2007-10-15 |
| MXPA03005581A (es) | 2003-10-06 |
| BR0116352A (pt) | 2003-12-02 |
| JP2004519443A (ja) | 2004-07-02 |
| AU2002216107A1 (en) | 2002-07-01 |
| CN1481379A (zh) | 2004-03-10 |
| US20020198255A1 (en) | 2002-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FA | Abandonment or withdrawal |