CN1232504A - 在单链负义病毒目病毒内引起减毒的3'基因组启动子区和聚合酶基因中的突变 - Google Patents
在单链负义病毒目病毒内引起减毒的3'基因组启动子区和聚合酶基因中的突变 Download PDFInfo
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
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- C12N2760/18011—Paramyxoviridae
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2682396P | 1996-09-27 | 1996-09-27 | |
US60/026,823 | 1996-09-27 |
Publications (1)
Publication Number | Publication Date |
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CN1232504A true CN1232504A (zh) | 1999-10-20 |
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ID=21833976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97198321A Pending CN1232504A (zh) | 1996-09-27 | 1997-09-19 | 在单链负义病毒目病毒内引起减毒的3'基因组启动子区和聚合酶基因中的突变 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0932684A2 (pt) |
JP (1) | JP2000517194A (pt) |
KR (1) | KR20000048628A (pt) |
CN (1) | CN1232504A (pt) |
AU (1) | AU4427897A (pt) |
BR (1) | BR9712138A (pt) |
CA (1) | CA2265554A1 (pt) |
WO (1) | WO1998013501A2 (pt) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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BR9909076A (pt) * | 1998-03-26 | 2000-12-05 | American Cyanamid Co | Vìrus atenuado do sarampo, recombinantemente gerado, isolado, vìrus do sarampo, vìrus sincicial respiratório humano (rsv), subgrupo b, atenuado, recombinantemente gerado, isolado, o rsv, subgrupo b, vacina processo para imunização de um indivìduo para induzir proteção contra vìrus do sarampo, processo para imunização de um indivìduo para induzir proteção contra o rsv, subgrupo b, composição, processo para produção de vìrus do sarampo infeccioso atenuado, processo para produção de rsv infeccioso atenuado subgrupo b |
ES2358315T3 (es) * | 1998-06-03 | 2011-05-09 | Wyeth Holdings Corporation | Procedimientos novedosos para rescatar virus de arn. |
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US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
WO2001077394A1 (en) | 2000-04-10 | 2001-10-18 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
MXPA02012256A (es) | 2000-06-23 | 2003-04-25 | American Cyanamid Co | Proteinas v de morbillivirus modificados. |
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EP1485468A4 (en) | 2002-02-21 | 2007-01-03 | Medimmune Vaccines Inc | EXPRESSION SYSTEMS OF RECOMBINANT PARAINFLUENZA VIRUSES AND VACCINES COMPRISING HETEROLOGOUS ANTIGENS DERIVED FROM METAPNEUMOVIRUS |
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DK1375670T3 (da) | 2002-06-20 | 2013-09-23 | Pasteur Institut | Rekombinante mæslingevira, der udtrykker epitoper af RNA-viras antigener, samt anvendelse af de rekombinante vira til fremstilling af vaccinesammensætninger |
EP2110382A1 (en) * | 2002-06-20 | 2009-10-21 | Institut Pasteur | Infectious cDNA of an improved vaccine strain of measles virus, use for immunogenic compositions |
CA2432738A1 (en) * | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
ATE469170T1 (de) | 2003-03-28 | 2010-06-15 | Medimmune Llc | Zusammensetzungen und verfahren mit dem respiratory syncytial virus untergruppe b stamm 9320 |
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EP2441471B1 (en) | 2005-03-08 | 2014-10-08 | MedImmune, LLC | Reassortant influenza viruses |
RU2008101367A (ru) | 2005-06-21 | 2009-08-10 | Медиммун, Ллк (Us) | Способы и композиции для экспрессии отрицательной смысловой вирусной рнк в собачьих клетках |
US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
PT2529747T (pt) | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
BRPI0710626A2 (pt) | 2006-04-19 | 2011-08-16 | Medimmune Llc | ácido nucleico isolado, vetor de expressão, métodos para produzir um rna genÈmico da influenza e um vìrus da influenza recombinante, célula, método para gerar em células caninas cultivadas um vìrus de rna, vìrus da influenza, e, sequência de ácido nucleico isolado |
US7601356B2 (en) | 2006-07-21 | 2009-10-13 | Medimmune, Llc | Methods and compositions for increasing replication capacity of an influenza virus |
CN104278014A (zh) | 2006-08-09 | 2015-01-14 | 米迪缪尼有限公司 | 流感血凝素和神经氨酸酶变体 |
JP2010514424A (ja) | 2006-12-22 | 2010-05-06 | ザ ペン ステート リサーチ ファウンデーション | 改変ポリメラーゼおよび弱毒化ウイルスならびにそれらの使用方法 |
US8673613B2 (en) | 2007-06-18 | 2014-03-18 | Medimmune, Llc | Influenza B viruses having alterations in the hemaglutinin polypeptide |
EP2318043A4 (en) | 2008-07-11 | 2012-01-25 | Medimmune Llc | INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS |
CN102203122A (zh) | 2008-11-05 | 2011-09-28 | 惠氏有限责任公司 | 用于预防β-溶血链球菌(BHS)疾病的多组分免疫原性组合物 |
EP2393921B1 (en) | 2009-02-05 | 2015-07-15 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
US8613935B2 (en) | 2009-02-12 | 2013-12-24 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
WO2011014504A1 (en) | 2009-07-27 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Recombinant influenza virus vectors and uses thereof |
WO2011014645A1 (en) | 2009-07-30 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Influenza viruses and uses thereof |
WO2011123495A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
EP2420242A1 (en) | 2010-08-20 | 2012-02-22 | Lauer, Ulrich M. | Oncolytic measles virus |
US9441205B2 (en) | 2011-06-08 | 2016-09-13 | Vishwas Joshi | Two plasmid mammalian expression system |
CN103906843B (zh) * | 2011-06-08 | 2016-12-07 | 维什瓦斯·乔希 | 双质粒哺乳动物表达系统 |
US10131695B2 (en) | 2011-09-20 | 2018-11-20 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
WO2014043518A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
CA2895508A1 (en) | 2012-12-18 | 2014-06-26 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
MD4655C1 (ro) | 2013-03-14 | 2020-06-30 | Icahn School Of Medicine At Mount Sinai | Virusurile bolii de Newcastle şi utilizarea acestora |
WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
CN107073099B (zh) | 2014-02-27 | 2022-09-27 | 默沙东公司 | 用于治疗癌症的联合方法 |
JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
EA201791907A1 (ru) | 2015-02-26 | 2018-02-28 | Бёрингер Ингельхайм Ветмедика Гмбх | Бивалентная вакцина против вируса свиного гриппа |
EP3331554B1 (en) | 2015-08-03 | 2022-05-11 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use |
AU2016308917A1 (en) | 2015-08-20 | 2018-03-15 | Cornell University | Live-attenuated vaccine having mutations in viral polymerase for the treatment and prevention of canine influenza virus |
WO2017031401A2 (en) | 2015-08-20 | 2017-02-23 | University Of Rochester | Ns1 truncated virus for the development of canine influenza vaccines |
WO2017031408A1 (en) | 2015-08-20 | 2017-02-23 | University Of Rochester | Single-cycle virus for the development of canine influenza vaccines |
EP3463439B1 (en) | 2016-06-03 | 2022-08-03 | University of Rochester | Equine influenza virus live-attenuated vaccines |
US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
CA3058652A1 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
AR114410A1 (es) | 2018-02-27 | 2020-09-02 | Univ Rochester | Vacuna multivalente contra influenza viva atenuada para prevenir y controlar el virus influenza equino (vie) en caballos |
US11166996B2 (en) | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
WO2020176709A1 (en) | 2019-02-27 | 2020-09-03 | University Of Rochester | Multivalent live-attenuated influenza vaccine for prevention and control of equine influenza virus (eiv) in horses |
US11103576B1 (en) | 2020-06-15 | 2021-08-31 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Measles virus vaccine expressing SARS-COV-2 protein(s) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7007491A (en) * | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
JP3045581B2 (ja) * | 1991-10-14 | 2000-05-29 | 社団法人北里研究所 | 麻疹ワクチンウイルス株同定方法 |
ES2247584T3 (es) * | 1992-04-14 | 2006-03-01 | The Mount Sinai School Of Medicine Of The City University Of New York | Virus atenuados por ingenieria genetica. |
IL105456A (en) * | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
TW275632B (pt) * | 1992-04-21 | 1996-05-11 | American Cyanamid Co | |
DK0702085T4 (da) * | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
-
1997
- 1997-09-19 CA CA002265554A patent/CA2265554A1/en not_active Abandoned
- 1997-09-19 WO PCT/US1997/016718 patent/WO1998013501A2/en not_active Application Discontinuation
- 1997-09-19 BR BR9712138-0A patent/BR9712138A/pt not_active Application Discontinuation
- 1997-09-19 KR KR1019990702569A patent/KR20000048628A/ko not_active Application Discontinuation
- 1997-09-19 EP EP97942613A patent/EP0932684A2/en not_active Withdrawn
- 1997-09-19 JP JP10515749A patent/JP2000517194A/ja not_active Ceased
- 1997-09-19 AU AU44278/97A patent/AU4427897A/en not_active Abandoned
- 1997-09-19 CN CN97198321A patent/CN1232504A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20000048628A (ko) | 2000-07-25 |
AU4427897A (en) | 1998-04-17 |
EP0932684A2 (en) | 1999-08-04 |
BR9712138A (pt) | 2000-01-18 |
CA2265554A1 (en) | 1998-04-02 |
JP2000517194A (ja) | 2000-12-26 |
WO1998013501A3 (en) | 1998-08-13 |
WO1998013501A2 (en) | 1998-04-02 |
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