CN1228765A - 新脒基衍生物和它们作为凝血酶抑制剂的用途 - Google Patents

新脒基衍生物和它们作为凝血酶抑制剂的用途 Download PDF

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Publication number
CN1228765A
CN1228765A CN97197578A CN97197578A CN1228765A CN 1228765 A CN1228765 A CN 1228765A CN 97197578 A CN97197578 A CN 97197578A CN 97197578 A CN97197578 A CN 97197578A CN 1228765 A CN1228765 A CN 1228765A
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China
Prior art keywords
formula
compound
ethoxy
aminoiminomethylphenyl
phenyl
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Pending
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CN97197578A
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English (en)
Chinese (zh)
Inventor
T·安东松
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AstraZeneca AB
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Astra AB
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Publication of CN1228765A publication Critical patent/CN1228765A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/71—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5304—Acyclic saturated phosphine oxides or thioxides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN97197578A 1996-07-04 1997-06-26 新脒基衍生物和它们作为凝血酶抑制剂的用途 Pending CN1228765A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE96026463 1996-07-04
SE9602646A SE9602646D0 (sv) 1996-07-04 1996-07-04 Pharmaceutically-useful compounds

Publications (1)

Publication Number Publication Date
CN1228765A true CN1228765A (zh) 1999-09-15

Family

ID=20403276

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97197578A Pending CN1228765A (zh) 1996-07-04 1997-06-26 新脒基衍生物和它们作为凝血酶抑制剂的用途

Country Status (24)

Country Link
US (2) US6221898B1 (enExample)
EP (1) EP0917528B1 (enExample)
JP (1) JP2000515505A (enExample)
KR (1) KR20000022437A (enExample)
CN (1) CN1228765A (enExample)
AR (1) AR007614A1 (enExample)
AT (1) ATE224365T1 (enExample)
BR (1) BR9710142A (enExample)
CA (1) CA2260190A1 (enExample)
CZ (1) CZ1299A3 (enExample)
DE (1) DE69715635T2 (enExample)
EE (1) EE9900006A (enExample)
HU (1) HUP9902410A3 (enExample)
ID (1) ID19479A (enExample)
IL (1) IL127885A0 (enExample)
IS (1) IS4930A (enExample)
NO (1) NO986180L (enExample)
NZ (1) NZ333394A (enExample)
PL (1) PL331047A1 (enExample)
SE (1) SE9602646D0 (enExample)
SK (1) SK172098A3 (enExample)
TR (1) TR199802767T2 (enExample)
WO (1) WO1998001422A1 (enExample)
ZA (1) ZA975591B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100439329C (zh) * 2000-10-04 2008-12-03 橘生药品工业株式会社 5-脒基-2-羟基苯磺酰胺衍生物,含有它的药用组合物以及制备它们用的中间体
CN102358753A (zh) * 2011-10-14 2012-02-22 山西大学 一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100439329C (zh) * 2000-10-04 2008-12-03 橘生药品工业株式会社 5-脒基-2-羟基苯磺酰胺衍生物,含有它的药用组合物以及制备它们用的中间体
CN102358753A (zh) * 2011-10-14 2012-02-22 山西大学 一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用
CN102358753B (zh) * 2011-10-14 2013-06-05 山西大学 一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用

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Publication number Publication date
WO1998001422A1 (en) 1998-01-15
SK172098A3 (en) 1999-06-11
DE69715635T2 (de) 2003-08-07
ATE224365T1 (de) 2002-10-15
JP2000515505A (ja) 2000-11-21
TR199802767T2 (xx) 1999-04-21
CA2260190A1 (en) 1998-01-15
IL127885A0 (en) 1999-10-28
IS4930A (is) 1998-12-21
EE9900006A (et) 1999-06-15
EP0917528A1 (en) 1999-05-26
ZA975591B (en) 1998-12-24
AU726236B2 (en) 2000-11-02
US7074820B2 (en) 2006-07-11
DE69715635D1 (de) 2002-10-24
PL331047A1 (en) 1999-06-21
AR007614A1 (es) 1999-11-10
AU3562897A (en) 1998-02-02
CZ1299A3 (cs) 1999-06-16
SE9602646D0 (sv) 1996-07-04
BR9710142A (pt) 1999-08-10
NZ333394A (en) 2000-08-25
NO986180L (no) 1999-03-04
ID19479A (id) 1998-07-16
EP0917528B1 (en) 2002-09-18
NO986180D0 (no) 1998-12-29
KR20000022437A (ko) 2000-04-25
US20020040043A1 (en) 2002-04-04
HUP9902410A3 (en) 2001-10-29
US6221898B1 (en) 2001-04-24
HUP9902410A2 (hu) 1999-11-29

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