CN1219764C - 用ω－羧基芳基取代的二苯脲作为raf激酶抑制剂 - Google Patents

用ω－羧基芳基取代的二苯脲作为raf激酶抑制剂 Download PDF

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Publication number
CN1219764C
CN1219764C CNB008026858A CN00802685A CN1219764C CN 1219764 C CN1219764 C CN 1219764C CN B008026858 A CNB008026858 A CN B008026858A CN 00802685 A CN00802685 A CN 00802685A CN 1219764 C CN1219764 C CN 1219764C
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phenyl
acid
trifluoromethyl
urea
chloro
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Chinese (zh)
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CN1341098A (zh
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B·里德
J·迪马
U·基海尔
T·B·洛因格
W·J·斯科特
R·A·史密斯
J·E·伍德
M-K·莫纳汉
R·纳特罗
J·雷尼克
R·N·西布利
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Bayer Pharmaceuticals Corp
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Bayer Corp
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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