AR035310A1 - Difenilureas substituidas con omega carboxiarilo como inhibidores de raf quinasa; sus composiciones farmaceuticas y un metodo para el tratamiento del crecimiento de celulas cancerosas - Google Patents
Difenilureas substituidas con omega carboxiarilo como inhibidores de raf quinasa; sus composiciones farmaceuticas y un metodo para el tratamiento del crecimiento de celulas cancerosasInfo
- Publication number
- AR035310A1 AR035310A1 ARP000100153A ARP000100153A AR035310A1 AR 035310 A1 AR035310 A1 AR 035310A1 AR P000100153 A ARP000100153 A AR P000100153A AR P000100153 A ARP000100153 A AR P000100153A AR 035310 A1 AR035310 A1 AR 035310A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- halogen
- carbon
- carbon atoms
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 17
- 229910052760 oxygen Inorganic materials 0.000 abstract 17
- 229910052717 sulfur Inorganic materials 0.000 abstract 17
- 229910052736 halogen Inorganic materials 0.000 abstract 15
- 150000002367 halogens Chemical group 0.000 abstract 15
- 125000004432 carbon atom Chemical group C* 0.000 abstract 14
- 125000005842 heteroatom Chemical group 0.000 abstract 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 12
- 229910052799 carbon Chemical group 0.000 abstract 12
- 125000001424 substituent group Chemical group 0.000 abstract 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000004122 cyclic group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 102000009929 raf Kinases Human genes 0.000 abstract 3
- 108010077182 raf Kinases Proteins 0.000 abstract 3
- 239000011593 sulfur Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 208000003200 Adenoma Diseases 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010048832 Colon adenoma Diseases 0.000 abstract 1
- 108091008648 NR7C Proteins 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000025113 myeloid leukemia Diseases 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 125000005750 substituted cyclic group Chemical group 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
- 125000006168 tricyclic group Chemical group 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 abstract 1
Classifications
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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WO1998052558A1 (en) * | 1997-05-23 | 1998-11-26 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS |
JP2002500650A (ja) * | 1997-05-23 | 2002-01-08 | バイエル、コーポレイション | Rafキナーゼ阻害剤 |
WO1999020617A1 (en) * | 1997-10-21 | 1999-04-29 | Active Biotech Ab | Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors |
CN1213022C (zh) * | 1997-12-22 | 2005-08-03 | 拜尔有限公司 | 用对称和不对称的取代二苯脲抑制raf激酶 |
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