CN100522934C - 用ω-羧基芳基取代的二苯脲作为raf激酶抑制剂 - Google Patents

用ω-羧基芳基取代的二苯脲作为raf激酶抑制剂 Download PDF

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CN100522934C
CN100522934C CNB2005100895046A CN200510089504A CN100522934C CN 100522934 C CN100522934 C CN 100522934C CN B2005100895046 A CNB2005100895046 A CN B2005100895046A CN 200510089504 A CN200510089504 A CN 200510089504A CN 100522934 C CN100522934 C CN 100522934C
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compound
acid
trifluoromethyl
group
phenyl
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CN1721397A (zh
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B·里德
J·迪马
U·基海尔
T·B·洛因格
W·J·斯科特
R·A·史密斯
J·E·伍德
M-K·莫纳汉
R·纳特罗
J·雷尼克
R·N·西布利
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Bayer Pharmaceuticals Corp
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Bayer Corp
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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