SI1797037T1 - Postopek priprave 4-(4-((((4-kloro-3-(trifluorometil)fenil)amino)karbonil)amino) fenioksi)N-metilpiridin-2-karboksamida - Google Patents
Postopek priprave 4-(4-((((4-kloro-3-(trifluorometil)fenil)amino)karbonil)amino) fenioksi)N-metilpiridin-2-karboksamidaInfo
- Publication number
- SI1797037T1 SI1797037T1 SI200531947T SI200531947T SI1797037T1 SI 1797037 T1 SI1797037 T1 SI 1797037T1 SI 200531947 T SI200531947 T SI 200531947T SI 200531947 T SI200531947 T SI 200531947T SI 1797037 T1 SI1797037 T1 SI 1797037T1
- Authority
- SI
- Slovenia
- Prior art keywords
- phenylćaminoćcarbonyl
- aminoćphenyoxyćn
- methylpyridine
- carboxamide
- trifluoromethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04023131 | 2004-09-29 | ||
PCT/EP2005/010118 WO2006034796A1 (en) | 2004-09-29 | 2005-09-20 | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
EP05794785.5A EP1797037B1 (en) | 2004-09-29 | 2005-09-20 | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyoxy}n-methylpyridine-2-carboxamide |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1797037T1 true SI1797037T1 (sl) | 2015-06-30 |
Family
ID=35457568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200531947T SI1797037T1 (sl) | 2004-09-29 | 2005-09-20 | Postopek priprave 4-(4-((((4-kloro-3-(trifluorometil)fenil)amino)karbonil)amino) fenioksi)N-metilpiridin-2-karboksamida |
Country Status (35)
Country | Link |
---|---|
US (1) | US8124782B2 (sl) |
EP (1) | EP1797037B1 (sl) |
JP (2) | JP2008514657A (sl) |
KR (1) | KR101263032B1 (sl) |
CN (1) | CN101052619B (sl) |
AR (1) | AR053973A1 (sl) |
AU (1) | AU2005289099B2 (sl) |
BR (1) | BRPI0515944B1 (sl) |
CA (1) | CA2581835C (sl) |
CU (1) | CU23754B7 (sl) |
CY (1) | CY1116126T1 (sl) |
DK (1) | DK1797037T3 (sl) |
DO (1) | DOP2005000183A (sl) |
EC (1) | ECSP077357A (sl) |
ES (1) | ES2532377T3 (sl) |
GT (1) | GT200500269A (sl) |
HK (1) | HK1113484A1 (sl) |
HN (1) | HN2005000768A (sl) |
HR (1) | HRP20150295T1 (sl) |
IL (1) | IL182046A0 (sl) |
MA (1) | MA28883B1 (sl) |
MY (1) | MY149873A (sl) |
NO (1) | NO339647B1 (sl) |
NZ (1) | NZ554119A (sl) |
PE (5) | PE20091586A1 (sl) |
PL (1) | PL1797037T3 (sl) |
PT (1) | PT1797037E (sl) |
SG (1) | SG155997A1 (sl) |
SI (1) | SI1797037T1 (sl) |
SV (1) | SV2006002243A (sl) |
TW (1) | TWI382973B (sl) |
UA (1) | UA90691C2 (sl) |
UY (1) | UY29143A1 (sl) |
WO (1) | WO2006034796A1 (sl) |
ZA (1) | ZA200702511B (sl) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000041698A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
AU2003209116A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
DE602004007382T2 (de) | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
DE602004010407T2 (de) | 2003-07-23 | 2008-10-16 | Bayer Pharmaceuticals Corp., West Haven | Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden |
EP1797038B1 (en) | 2004-09-29 | 2012-06-13 | Bayer Pharma Aktiengesellschaft | Thermodynamically stable form of bay 43-9006 tosylate |
UA90691C2 (en) | 2004-09-29 | 2010-05-25 | Баер Шеринг Фарма Акциенгезельшафт | Process for the preparation of 4-{ 4-[({ [4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
CA2601955C (en) | 2005-03-07 | 2012-07-10 | Bayer Healthcare Ag | Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer |
AR062927A1 (es) * | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
CA2669158A1 (en) * | 2006-11-14 | 2008-05-22 | Bayer Schering Pharma Aktiengesellschaft | Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide |
NZ583790A (en) | 2007-09-10 | 2012-04-27 | Cipla Ltd | Process for the preparation the raf kinase inhibitor sorafenib and intermediates for use in the process |
WO2009054004A2 (en) * | 2007-10-22 | 2009-04-30 | Natco Pharma Limited | Process for the preparation of sorafenib |
EP2231612A1 (en) | 2008-01-17 | 2010-09-29 | Sicor, Inc. | Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof |
US20090253913A1 (en) * | 2008-03-06 | 2009-10-08 | Pierluigi Rossetto | Process for the preparation of sorafenib and salts thereof |
CN103254126A (zh) * | 2008-09-19 | 2013-08-21 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
WO2011036647A1 (en) | 2009-09-24 | 2011-03-31 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
WO2011036648A1 (en) | 2009-09-24 | 2011-03-31 | Ranbaxy Laboratories Limited | Polymorphs of sorafenib acid addition salts |
US8552197B2 (en) * | 2009-11-12 | 2013-10-08 | Ranbaxy Laboratories Limited | Sorafenib ethylsulfonate salt, process for preparation and use |
WO2011076711A2 (en) | 2009-12-23 | 2011-06-30 | Ratiopharm Gmbh | Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide |
AU2011210326B2 (en) | 2010-01-29 | 2014-10-09 | Sun Pharmaceutical Industries Limited | Sorafenib dimethyl sulphoxide solvate |
CN102190616B (zh) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
CN102617458A (zh) * | 2010-05-18 | 2012-08-01 | 张南 | 抗癌用化合物的制备方法 |
JP2013531067A (ja) | 2010-07-19 | 2013-08-01 | バイエル ヘルスケア リミティド ライアビリティ カンパニー | 疾病及び状態の処置及び予防のためのフルオロ置換オメガ−カルボキシアリールジフェニル尿素を用いた組み合わせ薬 |
PE20140165A1 (es) | 2010-10-01 | 2014-02-26 | Bayer Ip Gmbh | Combinaciones que contienen n-(2-arilamino)arilsulfonamida |
WO2012071425A1 (en) | 2010-11-22 | 2012-05-31 | Teva Pharmaceutical Industries Ltd. | Solid state forms of sorafenib besylate, and processes for preparations thereof |
EP2559431A1 (en) | 2011-08-17 | 2013-02-20 | Ratiopharm GmbH | Pharmaceutical composition comprising 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
CN103664771B (zh) * | 2012-09-19 | 2016-03-30 | 齐鲁制药有限公司 | 索拉非尼的晶型a及其制备方法 |
WO2014118807A1 (en) * | 2013-02-04 | 2014-08-07 | Intas Pharmaceuticals Limited | A novel process for the preparation of sorafenib tosylate form iii |
CN104710354A (zh) * | 2013-12-13 | 2015-06-17 | 江苏豪森药业股份有限公司 | 高纯度索拉非尼的制备方法 |
CN104761492A (zh) * | 2014-01-03 | 2015-07-08 | 正大天晴药业集团股份有限公司 | 对甲苯磺酸索拉非尼的晶型及其制备方法 |
CN104177292A (zh) * | 2014-08-08 | 2014-12-03 | 亿腾药业(泰州)有限公司 | 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法 |
CN110204483B (zh) * | 2014-12-01 | 2021-06-29 | 石药集团中奇制药技术(石家庄)有限公司 | 一种甲苯磺酸索拉非尼新晶型及其制备方法 |
EP3109236B1 (en) | 2015-06-23 | 2017-08-09 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Scalable process for the preparation of sorafenib tosylate ethanol solvate and sorafenib tosylate form iii |
CN105181844A (zh) * | 2015-09-11 | 2015-12-23 | 江苏嘉逸医药有限公司 | 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法 |
CN105585523A (zh) * | 2015-12-29 | 2016-05-18 | 上海北卡医药技术有限公司 | 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途 |
CN107840823B (zh) * | 2016-09-20 | 2021-08-17 | 意大利合成制造有限公司 | 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法 |
CN107915676A (zh) * | 2017-10-26 | 2018-04-17 | 魏海霞 | 索拉非尼的制备方法 |
CN109796400B (zh) * | 2017-11-16 | 2022-07-29 | 四川科伦药物研究院有限公司 | 一种甲苯磺酸索拉菲尼晶型及其制备方法 |
CN113773249A (zh) * | 2020-06-10 | 2021-12-10 | 杭州中美华东制药有限公司 | 索拉非尼游离碱晶型Form X及其制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU86960A1 (fr) * | 1987-07-31 | 1989-03-08 | Oreal | Procede de preparation de piperidino-6 diamino-2,4 pyrimidine oxyde-3 et composes nouveaux |
JPH02934A (ja) * | 1988-05-27 | 1990-01-05 | Konica Corp | 非線形光学材料 |
JP2971291B2 (ja) * | 1993-06-02 | 1999-11-02 | 田辺製薬株式会社 | 光学活性2−アミノ酪酸の製法 |
JP3866323B2 (ja) * | 1996-03-27 | 2007-01-10 | ポーラ化成工業株式会社 | 新規n−ベンジルベンズアミド誘導体 |
JPH09316069A (ja) * | 1996-03-28 | 1997-12-09 | Ajinomoto Co Inc | 新規キサントン誘導体 |
EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
TR200102020T2 (tr) * | 1999-01-13 | 2003-01-21 | Bayer Corporation | Raf kinaz inhibitörleri olarak w-karboksiaril sübstitüe edilmiş difenil üreler. |
GB2367816A (en) * | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
DE60216139T3 (de) * | 2001-12-03 | 2018-11-15 | Bayer Healthcare Llc | Arylharnstoff-verbindungen in kombination mit anderen zytostatisch oder zytotoxisch wirksamen stoffen zur behandlungen menschlicher krebserkrankungen |
US20030207872A1 (en) * | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
DE10203086A1 (de) * | 2002-01-28 | 2003-07-31 | Bayer Ag | 5-Ring Heterozyklen |
AU2003209116A1 (en) * | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
KR20050087776A (ko) * | 2002-08-13 | 2005-08-31 | 산도즈 아게 | 세프디니르 중간체 |
AU2003301430A1 (en) * | 2002-10-21 | 2004-05-04 | Kirin Beer Kabushiki Kaisha | N-{2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl}-n'-(5-methyl-3-isoxazolyl)urea salt in crystalline form |
DE602004007382T2 (de) * | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
UA90691C2 (en) | 2004-09-29 | 2010-05-25 | Баер Шеринг Фарма Акциенгезельшафт | Process for the preparation of 4-{ 4-[({ [4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
-
2005
- 2005-09-20 UA UAA200704750A patent/UA90691C2/ru unknown
- 2005-09-20 CN CN2005800373684A patent/CN101052619B/zh active Active
- 2005-09-20 US US11/664,332 patent/US8124782B2/en active Active
- 2005-09-20 ES ES05794785.5T patent/ES2532377T3/es active Active
- 2005-09-20 EP EP05794785.5A patent/EP1797037B1/en active Active
- 2005-09-20 PT PT05794785T patent/PT1797037E/pt unknown
- 2005-09-20 WO PCT/EP2005/010118 patent/WO2006034796A1/en active Application Filing
- 2005-09-20 SI SI200531947T patent/SI1797037T1/sl unknown
- 2005-09-20 SG SG200906449-4A patent/SG155997A1/en unknown
- 2005-09-20 KR KR1020077009652A patent/KR101263032B1/ko active IP Right Grant
- 2005-09-20 CA CA2581835A patent/CA2581835C/en active Active
- 2005-09-20 PL PL05794785T patent/PL1797037T3/pl unknown
- 2005-09-20 BR BRPI0515944-0A patent/BRPI0515944B1/pt active IP Right Grant
- 2005-09-20 NZ NZ554119A patent/NZ554119A/en unknown
- 2005-09-20 JP JP2007533904A patent/JP2008514657A/ja active Pending
- 2005-09-20 DK DK05794785T patent/DK1797037T3/en active
- 2005-09-20 AU AU2005289099A patent/AU2005289099B2/en active Active
- 2005-09-23 DO DO2005000183A patent/DOP2005000183A/es unknown
- 2005-09-26 AR ARP050104020A patent/AR053973A1/es active IP Right Grant
- 2005-09-27 MY MYPI20054553A patent/MY149873A/en unknown
- 2005-09-28 TW TW094133620A patent/TWI382973B/zh active
- 2005-09-28 PE PE2009000511A patent/PE20091586A1/es not_active Application Discontinuation
- 2005-09-28 PE PE2009000512A patent/PE20091587A1/es active IP Right Grant
- 2005-09-28 GT GT200500269A patent/GT200500269A/es unknown
- 2005-09-28 PE PE2009000509A patent/PE20091584A1/es active IP Right Grant
- 2005-09-28 PE PE2005001144A patent/PE20060825A1/es active IP Right Grant
- 2005-09-28 PE PE2009000510A patent/PE20091585A1/es active IP Right Grant
- 2005-09-28 UY UY29143A patent/UY29143A1/es active IP Right Grant
- 2005-09-29 SV SV2005002243A patent/SV2006002243A/es active IP Right Grant
- 2005-10-04 HN HN2005000768A patent/HN2005000768A/es unknown
-
2007
- 2007-03-20 IL IL182046A patent/IL182046A0/en active IP Right Grant
- 2007-03-26 CU CU20070069A patent/CU23754B7/es active IP Right Grant
- 2007-03-27 ZA ZA200702511A patent/ZA200702511B/en unknown
- 2007-03-28 EC EC2007007357A patent/ECSP077357A/es unknown
- 2007-03-30 MA MA29788A patent/MA28883B1/fr unknown
- 2007-04-26 NO NO20072173A patent/NO339647B1/no unknown
-
2008
- 2008-04-01 HK HK08103596.4A patent/HK1113484A1/xx unknown
-
2012
- 2012-11-02 JP JP2012242831A patent/JP5583190B2/ja active Active
-
2015
- 2015-03-16 HR HRP20150295TT patent/HRP20150295T1/hr unknown
- 2015-03-17 CY CY20151100268T patent/CY1116126T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI1797037T1 (sl) | Postopek priprave 4-(4-((((4-kloro-3-(trifluorometil)fenil)amino)karbonil)amino) fenioksi)N-metilpiridin-2-karboksamida | |
TWI340137B (en) | Preparation process | |
IL173456A0 (en) | Process for the preparation of 4-amino-3-quinolinecarbonitriles | |
HK1163672A1 (en) | Processes for the preparation of compounds | |
HK1085480A1 (en) | Process for the preparation of roflumilast | |
TWI367257B (en) | Process for the preparation of 2-butanol | |
PT1748990E (pt) | Processo para a preparação de telmisartan | |
ZA200804264B (en) | Process for the preparation of ferri-succinylcasein | |
IL177561A0 (en) | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | |
IL175743A0 (en) | Process for the preparation of thiazolopyrimidines | |
PL1763508T3 (pl) | Sposób wytwarzania mocznika | |
ZA200601910B (en) | Process for the preparation of organosilances | |
GB2436262B (en) | Process for the preparation of pantoprazole sodium | |
IL182421A0 (en) | Process for the preparation of pyrazoles | |
GB0406635D0 (en) | Process for the preparation of an emulsion | |
IL191052A0 (en) | Process for the preparation of tamsulosin and related compounds | |
PL378094A1 (pl) | Sposób wytwarzania aldehydów | |
HK1095145A1 (en) | Process for the preparation of n-arylmorpholinones n- | |
HUP0401379A3 (en) | Process for the preparation of risperidon | |
IL178960A0 (en) | Process for the preparation of pyridin-2-ylmethylsulphinyl-1h-benzimidazol compounds | |
IL177353A0 (en) | Process for the preparation of aq4n | |
HK1128287A1 (en) | Process for the preparation of tryptase inhibitors | |
IL178237A0 (en) | Process for the preparation of rosiglitazone | |
GB0415076D0 (en) | Process for the preparation of gabapentin | |
HK1087111A1 (en) | Process for the preparation of nicotinaldehydes |