PE20091587A1 - Procedimiento para preparar 4-cloro-n-metilpiridin-2-carboxamida - Google Patents
Procedimiento para preparar 4-cloro-n-metilpiridin-2-carboxamidaInfo
- Publication number
- PE20091587A1 PE20091587A1 PE2009000512A PE2009000512A PE20091587A1 PE 20091587 A1 PE20091587 A1 PE 20091587A1 PE 2009000512 A PE2009000512 A PE 2009000512A PE 2009000512 A PE2009000512 A PE 2009000512A PE 20091587 A1 PE20091587 A1 PE 20091587A1
- Authority
- PE
- Peru
- Prior art keywords
- methylpyridin
- carboxamide
- chlorine
- procedure
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Developing Agents For Electrophotography (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR 4-CLORO-N-METILPIRIDIN-2-CARBOXAMIDA QUE COMPRENDE: A) PREPARAR EL COMPUESTO CLORHIDRATO DE 4-CLOROPIRIDIN-2-CARBONILCLORURO USANDO UN DISOLVENTE INERTE HACIA CLORURO DE TIONILO, ANADIENDO CLORURO DE TIONILO A ACIDO 2-PICOLINICO Y SIN EL USO DE DIMETILFORMAMIDA; B) REACCIONAR CLORHIDRATO DE 4-CLOROPIRIDIN-2-CARBONILCLORURO CON UNA SOLUCION DE METILAMINA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04023131 | 2004-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091587A1 true PE20091587A1 (es) | 2009-11-05 |
Family
ID=35457568
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000509A PE20091584A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
PE2009000511A PE20091586A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
PE2009000512A PE20091587A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-cloro-n-metilpiridin-2-carboxamida |
PE2005001144A PE20060825A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
PE2009000510A PE20091585A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000509A PE20091584A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
PE2009000511A PE20091586A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005001144A PE20060825A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
PE2009000510A PE20091585A1 (es) | 2004-09-29 | 2005-09-28 | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]fenoxi}-n-metilpiridina-2-carboxamida y su sal tosilato |
Country Status (35)
Country | Link |
---|---|
US (1) | US8124782B2 (es) |
EP (1) | EP1797037B1 (es) |
JP (2) | JP2008514657A (es) |
KR (1) | KR101263032B1 (es) |
CN (1) | CN101052619B (es) |
AR (1) | AR053973A1 (es) |
AU (1) | AU2005289099B2 (es) |
BR (1) | BRPI0515944B1 (es) |
CA (1) | CA2581835C (es) |
CU (1) | CU23754B7 (es) |
CY (1) | CY1116126T1 (es) |
DK (1) | DK1797037T3 (es) |
DO (1) | DOP2005000183A (es) |
EC (1) | ECSP077357A (es) |
ES (1) | ES2532377T3 (es) |
GT (1) | GT200500269A (es) |
HK (1) | HK1113484A1 (es) |
HN (1) | HN2005000768A (es) |
HR (1) | HRP20150295T1 (es) |
IL (1) | IL182046A0 (es) |
MA (1) | MA28883B1 (es) |
MY (1) | MY149873A (es) |
NO (1) | NO339647B1 (es) |
NZ (1) | NZ554119A (es) |
PE (5) | PE20091584A1 (es) |
PL (1) | PL1797037T3 (es) |
PT (1) | PT1797037E (es) |
SG (1) | SG155997A1 (es) |
SI (1) | SI1797037T1 (es) |
SV (1) | SV2006002243A (es) |
TW (1) | TWI382973B (es) |
UA (1) | UA90691C2 (es) |
UY (1) | UY29143A1 (es) |
WO (1) | WO2006034796A1 (es) |
ZA (1) | ZA200702511B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
PT1478358E (pt) | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
CA2526617C (en) | 2003-05-20 | 2015-04-28 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
AU2004259760B9 (en) | 2003-07-23 | 2011-02-03 | Bayer Healthcare Llc | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
ES2387812T3 (es) * | 2004-09-29 | 2012-10-02 | Bayer Pharma Aktiengesellschaft | Forma termodinámicamente estable del tosilato BAY 43-9006 |
SI1797037T1 (sl) | 2004-09-29 | 2015-06-30 | Bayer Healthcare Llc | Postopek priprave 4-(4-((((4-kloro-3-(trifluorometil)fenil)amino)karbonil)amino) fenioksi)N-metilpiridin-2-karboksamida |
MX2007010856A (es) | 2005-03-07 | 2007-11-12 | Bayer Healthcare Ag | Composicion farmaceutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cancer. |
AR062927A1 (es) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
US20100113533A1 (en) * | 2006-11-14 | 2010-05-06 | Bayer Schering Pharma Aktiengesellschaft | Polymorph II of 4-[4-(Amino)-3- Fluorophenoxy]-N-Methylpyridine-2-Carboxamide |
KR101553211B1 (ko) * | 2007-09-10 | 2015-09-15 | 씨아이피엘에이 엘티디. | Raf 키나아제 저해제의 제조방법 및 상기 제조방법에 사용되는 중간체 |
WO2009054004A2 (en) * | 2007-10-22 | 2009-04-30 | Natco Pharma Limited | Process for the preparation of sorafenib |
EP2231612A1 (en) | 2008-01-17 | 2010-09-29 | Sicor, Inc. | Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof |
US20090253913A1 (en) * | 2008-03-06 | 2009-10-08 | Pierluigi Rossetto | Process for the preparation of sorafenib and salts thereof |
CN103254126A (zh) * | 2008-09-19 | 2013-08-21 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
CA2775229C (en) * | 2009-09-24 | 2014-07-29 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
WO2011036648A1 (en) | 2009-09-24 | 2011-03-31 | Ranbaxy Laboratories Limited | Polymorphs of sorafenib acid addition salts |
WO2011058522A1 (en) | 2009-11-12 | 2011-05-19 | Ranbaxy Laboratories Limited | Sorafenib ethylsulfonate salt, process for preparation and use |
WO2011076711A2 (en) | 2009-12-23 | 2011-06-30 | Ratiopharm Gmbh | Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide |
CA2788146C (en) | 2010-01-29 | 2014-11-25 | Ranbaxy Laboratories Limited | Sorafenib dimethtyl sulphoxide solvate |
CN102190616B (zh) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
CN102617458A (zh) * | 2010-05-18 | 2012-08-01 | 张南 | 抗癌用化合物的制备方法 |
US20130183268A1 (en) | 2010-07-19 | 2013-07-18 | Bayer Healthcare Llc | Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
JP2013538840A (ja) | 2010-10-01 | 2013-10-17 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換n−(2−アリールアミノ)アリールスルホンアミドを含有する組み合わせ |
WO2012071425A1 (en) | 2010-11-22 | 2012-05-31 | Teva Pharmaceutical Industries Ltd. | Solid state forms of sorafenib besylate, and processes for preparations thereof |
EP2559431A1 (en) | 2011-08-17 | 2013-02-20 | Ratiopharm GmbH | Pharmaceutical composition comprising 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
CN103664771B (zh) * | 2012-09-19 | 2016-03-30 | 齐鲁制药有限公司 | 索拉非尼的晶型a及其制备方法 |
WO2014118807A1 (en) * | 2013-02-04 | 2014-08-07 | Intas Pharmaceuticals Limited | A novel process for the preparation of sorafenib tosylate form iii |
CN104710354A (zh) * | 2013-12-13 | 2015-06-17 | 江苏豪森药业股份有限公司 | 高纯度索拉非尼的制备方法 |
CN104761492A (zh) * | 2014-01-03 | 2015-07-08 | 正大天晴药业集团股份有限公司 | 对甲苯磺酸索拉非尼的晶型及其制备方法 |
CN104177292A (zh) * | 2014-08-08 | 2014-12-03 | 亿腾药业(泰州)有限公司 | 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法 |
CN105439947A (zh) * | 2014-12-01 | 2016-03-30 | 石药集团中奇制药技术(石家庄)有限公司 | 一种甲苯磺酸索拉非尼新晶型及其制备方法 |
EP3109236B1 (en) | 2015-06-23 | 2017-08-09 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Scalable process for the preparation of sorafenib tosylate ethanol solvate and sorafenib tosylate form iii |
CN105181844A (zh) * | 2015-09-11 | 2015-12-23 | 江苏嘉逸医药有限公司 | 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法 |
CN105585523A (zh) * | 2015-12-29 | 2016-05-18 | 上海北卡医药技术有限公司 | 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途 |
CN107840823B (zh) * | 2016-09-20 | 2021-08-17 | 意大利合成制造有限公司 | 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法 |
CN107915676A (zh) * | 2017-10-26 | 2018-04-17 | 魏海霞 | 索拉非尼的制备方法 |
CN109796400B (zh) * | 2017-11-16 | 2022-07-29 | 四川科伦药物研究院有限公司 | 一种甲苯磺酸索拉菲尼晶型及其制备方法 |
CN113773249A (zh) * | 2020-06-10 | 2021-12-10 | 杭州中美华东制药有限公司 | 索拉非尼游离碱晶型Form X及其制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU86960A1 (fr) * | 1987-07-31 | 1989-03-08 | Oreal | Procede de preparation de piperidino-6 diamino-2,4 pyrimidine oxyde-3 et composes nouveaux |
JPH02934A (ja) * | 1988-05-27 | 1990-01-05 | Konica Corp | 非線形光学材料 |
JP2971291B2 (ja) * | 1993-06-02 | 1999-11-02 | 田辺製薬株式会社 | 光学活性2−アミノ酪酸の製法 |
JP3866323B2 (ja) * | 1996-03-27 | 2007-01-10 | ポーラ化成工業株式会社 | 新規n−ベンジルベンズアミド誘導体 |
JPH09316069A (ja) * | 1996-03-28 | 1997-12-09 | Ajinomoto Co Inc | 新規キサントン誘導体 |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
BRPI0007487B8 (pt) * | 1999-01-13 | 2021-05-25 | Bayer Healthcare Llc | difenil-uréias substituídas com w-carbóxi-arilas como inibidores de raf cinase |
WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
GB2367816A (en) * | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
WO2003047579A1 (en) * | 2001-12-03 | 2003-06-12 | Bayer Pharmaceuticals Corporation | Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers |
US20030207872A1 (en) * | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
DE10203086A1 (de) * | 2002-01-28 | 2003-07-31 | Bayer Ag | 5-Ring Heterozyklen |
PT1478358E (pt) * | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
DE60336331D1 (de) * | 2002-08-13 | 2011-04-21 | Sandoz Ag | Ein cefdinir-zwischenprodukt |
EP1559715B1 (en) * | 2002-10-21 | 2007-09-26 | Kirin Beer Kabushiki Kaisha | N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n'-(5-methyl-3-isoxazolyl)urea salt in crystalline form |
CA2526617C (en) | 2003-05-20 | 2015-04-28 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
SI1797037T1 (sl) | 2004-09-29 | 2015-06-30 | Bayer Healthcare Llc | Postopek priprave 4-(4-((((4-kloro-3-(trifluorometil)fenil)amino)karbonil)amino) fenioksi)N-metilpiridin-2-karboksamida |
-
2005
- 2005-09-20 SI SI200531947T patent/SI1797037T1/sl unknown
- 2005-09-20 WO PCT/EP2005/010118 patent/WO2006034796A1/en active Application Filing
- 2005-09-20 BR BRPI0515944-0A patent/BRPI0515944B1/pt active IP Right Grant
- 2005-09-20 ES ES05794785.5T patent/ES2532377T3/es active Active
- 2005-09-20 DK DK05794785T patent/DK1797037T3/en active
- 2005-09-20 KR KR1020077009652A patent/KR101263032B1/ko active IP Right Grant
- 2005-09-20 PT PT05794785T patent/PT1797037E/pt unknown
- 2005-09-20 UA UAA200704750A patent/UA90691C2/ru unknown
- 2005-09-20 PL PL05794785T patent/PL1797037T3/pl unknown
- 2005-09-20 SG SG200906449-4A patent/SG155997A1/en unknown
- 2005-09-20 CN CN2005800373684A patent/CN101052619B/zh active Active
- 2005-09-20 EP EP05794785.5A patent/EP1797037B1/en active Active
- 2005-09-20 NZ NZ554119A patent/NZ554119A/en unknown
- 2005-09-20 AU AU2005289099A patent/AU2005289099B2/en active Active
- 2005-09-20 JP JP2007533904A patent/JP2008514657A/ja active Pending
- 2005-09-20 CA CA2581835A patent/CA2581835C/en active Active
- 2005-09-20 US US11/664,332 patent/US8124782B2/en active Active
- 2005-09-23 DO DO2005000183A patent/DOP2005000183A/es unknown
- 2005-09-26 AR ARP050104020A patent/AR053973A1/es active IP Right Grant
- 2005-09-27 MY MYPI20054553A patent/MY149873A/en unknown
- 2005-09-28 PE PE2009000509A patent/PE20091584A1/es active IP Right Grant
- 2005-09-28 PE PE2009000511A patent/PE20091586A1/es not_active Application Discontinuation
- 2005-09-28 TW TW094133620A patent/TWI382973B/zh active
- 2005-09-28 GT GT200500269A patent/GT200500269A/es unknown
- 2005-09-28 PE PE2009000512A patent/PE20091587A1/es active IP Right Grant
- 2005-09-28 UY UY29143A patent/UY29143A1/es active IP Right Grant
- 2005-09-28 PE PE2005001144A patent/PE20060825A1/es active IP Right Grant
- 2005-09-28 PE PE2009000510A patent/PE20091585A1/es active IP Right Grant
- 2005-09-29 SV SV2005002243A patent/SV2006002243A/es active IP Right Grant
- 2005-10-04 HN HN2005000768A patent/HN2005000768A/es unknown
-
2007
- 2007-03-20 IL IL182046A patent/IL182046A0/en active IP Right Grant
- 2007-03-26 CU CU20070069A patent/CU23754B7/es active IP Right Grant
- 2007-03-27 ZA ZA200702511A patent/ZA200702511B/en unknown
- 2007-03-28 EC EC2007007357A patent/ECSP077357A/es unknown
- 2007-03-30 MA MA29788A patent/MA28883B1/fr unknown
- 2007-04-26 NO NO20072173A patent/NO339647B1/no unknown
-
2008
- 2008-04-01 HK HK08103596.4A patent/HK1113484A1/xx unknown
-
2012
- 2012-11-02 JP JP2012242831A patent/JP5583190B2/ja active Active
-
2015
- 2015-03-16 HR HRP20150295TT patent/HRP20150295T1/hr unknown
- 2015-03-17 CY CY20151100268T patent/CY1116126T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20091587A1 (es) | Procedimiento para preparar 4-cloro-n-metilpiridin-2-carboxamida | |
EP2141214A3 (en) | Novel organic electroluminescent compounds and organic electroluminescent device using the same | |
BRPI0607762B8 (pt) | análogos de glp-1, composição farmacêutica contendo os mesmos e uso de um composto | |
BRPI0615705A2 (pt) | processo para preparar um composto, e, composto | |
ECSP066540A (es) | Pentanoles transpuestos, un método para prepararlos y su uso como antiinflamatorios | |
CR8357A (es) | Derivados de tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorio | |
GT200500275A (es) | Nuevos herbicidas | |
BR0300500B1 (pt) | composiÇço poliolefÍnica, processo para estabilizaÇço de uma poliolefina e uso de uma mistura. | |
BRPI0506858A (pt) | composto, métodos de preparação de monoidrato de gaboxadol cristalino e de anidrato de gaboxadol cristalino, composição farmacêutica, e, uso de um composto | |
UY28014A1 (es) | Compuestos quimicos | |
CY1109896T1 (el) | Εξω- και διαστερεο- εκλεκτικες συνθεσεις αναλογων της ιμβακινης | |
UY27381A1 (es) | 2-tio-3,5-diciano-4-fenil-6-aminopiridinas sustituidas y su uso | |
MX2008013520A (es) | Agonistas del receptor de adenosina a3. | |
TW200619206A (en) | Chemokine-binding heterocyclic compound salts, and methods of use thereof | |
CL2004000449A1 (es) | Compuestos derivados de imidazol-4-il-etinil-piridina, para tratar trastornos mediados por el receptor mglur5; procedimiento de preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en | |
EA200300593A1 (ru) | Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора | |
CL2009001686A1 (es) | Procedimiento de preparacion de agomelatina; y los compuestos intermediarios considerados. | |
BRPI0611025A2 (pt) | composto, uso de um composto, e, composição farmacêuticamente aceitável | |
PA8577201A1 (es) | 3-fenil-propionamido, 3-fenil-acrilamido y derivados 3-fenil-propinamido como inhibidores de mao-b | |
DE502006009282D1 (de) | Verfahren zur substitution von indenofluorenen | |
MX2009009355A (es) | Compuesto de bencimidazol y uso farmaceutico del mismo. | |
BRPI0507847A (pt) | processo para a preparação de um composto, e, composto | |
ECSP10010168A (es) | Benzotiazolas como moduladores del receptor de ghrelina | |
PA8636101A1 (es) | Metodo para la preparacion de acidos hidroxamicos | |
EA200700550A1 (ru) | Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |