CN104710354A - 高纯度索拉非尼的制备方法 - Google Patents
高纯度索拉非尼的制备方法 Download PDFInfo
- Publication number
- CN104710354A CN104710354A CN201310690301.7A CN201310690301A CN104710354A CN 104710354 A CN104710354 A CN 104710354A CN 201310690301 A CN201310690301 A CN 201310690301A CN 104710354 A CN104710354 A CN 104710354A
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- CN
- China
- Prior art keywords
- methylene dichloride
- thf
- tetrahydrofuran
- reaction
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310690301.7A CN104710354A (zh) | 2013-12-13 | 2013-12-13 | 高纯度索拉非尼的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310690301.7A CN104710354A (zh) | 2013-12-13 | 2013-12-13 | 高纯度索拉非尼的制备方法 |
Publications (1)
Publication Number | Publication Date |
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CN104710354A true CN104710354A (zh) | 2015-06-17 |
Family
ID=53410144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310690301.7A Pending CN104710354A (zh) | 2013-12-13 | 2013-12-13 | 高纯度索拉非尼的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN104710354A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109422676A (zh) * | 2017-09-01 | 2019-03-05 | 广州白云山医药集团股份有限公司白云山制药总厂 | 索拉非尼晶型及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101052619A (zh) * | 2004-09-29 | 2007-10-10 | 拜耳医药保健股份公司 | 制备4-{4-[({[4-氯-3-(三氟甲基)苯基]氨基}羰基)氨基]苯氧基}-n-甲基吡啶-2-甲酰胺的方法 |
WO2011092663A2 (en) * | 2010-01-29 | 2011-08-04 | Ranbaxy Laboratories Limited | 4-(4-{3-[4-chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-n2-methylpyridine-2-carboxamide dimethyl sulphoxide solvate |
WO2013175483A1 (en) * | 2012-05-23 | 2013-11-28 | Shilpa Medicare Limited | Process for preparing crystalline sorafenib tosylate |
-
2013
- 2013-12-13 CN CN201310690301.7A patent/CN104710354A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101052619A (zh) * | 2004-09-29 | 2007-10-10 | 拜耳医药保健股份公司 | 制备4-{4-[({[4-氯-3-(三氟甲基)苯基]氨基}羰基)氨基]苯氧基}-n-甲基吡啶-2-甲酰胺的方法 |
WO2011092663A2 (en) * | 2010-01-29 | 2011-08-04 | Ranbaxy Laboratories Limited | 4-(4-{3-[4-chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-n2-methylpyridine-2-carboxamide dimethyl sulphoxide solvate |
WO2013175483A1 (en) * | 2012-05-23 | 2013-11-28 | Shilpa Medicare Limited | Process for preparing crystalline sorafenib tosylate |
Non-Patent Citations (5)
Title |
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DONALD BANKSTON,等: "A Scaleable Synthesis of BAY 43-9006: A Potent Raf Kinase Inhibitor for the Treatment of Cancer", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 * |
SCARPITTA, FRANCESCA,等: "Synthesis of protein kinase inhibitors", 《CHEMICKE LISTY 》 * |
吴思晋,等: "索拉非尼的合成工艺改进", 《齐鲁药事》 * |
孙超: "索拉非尼的合成工艺研究", 《黑龙江大学硕士学位论文》 * |
陈静,等: "抗肿瘤药物索拉非尼合成工艺的改进", 《烟台大学学报(自然科学与工程版)》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109422676A (zh) * | 2017-09-01 | 2019-03-05 | 广州白云山医药集团股份有限公司白云山制药总厂 | 索拉非尼晶型及其制备方法 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
CB02 | Change of applicant information |
Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. |
|
COR | Change of bibliographic data | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB02 | Change of applicant information |
Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: Jiangsu best Pharmaceutical Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: Jiangsu best Pharmaceutical Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
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COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160324 Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150617 |
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RJ01 | Rejection of invention patent application after publication |