BRPI0515944A - processo para a preparação de 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carboni l)amino]fenóxi}n-metilpiridina-2-carboxamida - Google Patents
processo para a preparação de 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carboni l)amino]fenóxi}n-metilpiridina-2-carboxamidaInfo
- Publication number
- BRPI0515944A BRPI0515944A BRPI0515944-0A BRPI0515944A BRPI0515944A BR PI0515944 A BRPI0515944 A BR PI0515944A BR PI0515944 A BRPI0515944 A BR PI0515944A BR PI0515944 A BRPI0515944 A BR PI0515944A
- Authority
- BR
- Brazil
- Prior art keywords
- amino
- chloro
- formula
- methylpyridine
- carboxamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
"PROCESSO PARA A PREPARAçãO DE 4-{4-¢({¢4-CLORO-3-(TRIFLUOROMETIL)FENIL!AMINO!CARBONI L)AMINO!FENóXI!N-METILPIRIDINA-2-CARBOXAMIDA". A presente invenção refere-se a um processo para preparo de 4-{4-¢({¢4-cloro-3-(trifluorometil)fenil!amino}carbonil)amino!fenóxi}-N- metilpiridina-2-carboxamida e seu sal de tosilato. Fórmula I, a qual compreende, em uma primeira etapa, reação do composto da fórmula (V) com isocianato de 4-cloro-3-trifluorometilfenila em um solvente orgânico não-clorado, inerte com relação a isocianatos, através de inicialmente carregamento do composto da fórmula (V) a uma temperatura de 20<198>C a 60<198>C e mistura com isocianato de 4-cloro-3-trifluorometilfenila de um tal modo que a temperatura de reação não exceda 70<198>C para produzir o composto da fórmula (II) e, em uma segunda etapa, mistura do composto da fórmula (II) com ácido p-toluenossulfónico em um solvente polar a uma temperatura de reação de 40<198>C até a temperatura de refluxo do solvente usado.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04023131.8 | 2004-09-29 | ||
| EP04023131 | 2004-09-29 | ||
| PCT/EP2005/010118 WO2006034796A1 (en) | 2004-09-29 | 2005-09-20 | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0515944A true BRPI0515944A (pt) | 2008-08-12 |
| BRPI0515944B1 BRPI0515944B1 (pt) | 2021-11-09 |
Family
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| B25A | Requested transfer of rights approved |
Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) Free format text: TRANSFERIDO POR FUSAO DE: BAYER HEALTHCARE AG |
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| B25D | Requested change of name of applicant approved |
Owner name: BAYER PHARMA AKTIENGESELLSCHAFT (DE) |
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| B25A | Requested transfer of rights approved |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE) |
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| B25A | Requested transfer of rights approved |
Owner name: BAYER HEALTHCARE LLC (US) |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 213/81 Ipc: C07D 213/81 (2006.01), A61P 35/00 (2006.01) |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/09/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |