CY1116126T1 - Διαδικασια για την παρασκευη 4-{4-[({[4-χλωρο-3-(τριφθορομεθυλ)φαινυλ]αμινο}καρβονυλ)αmινο]φαινοξυ}ν-μεθυλπυριδιν-2-καρβοξαμιδιου - Google Patents

Διαδικασια για την παρασκευη 4-{4-[({[4-χλωρο-3-(τριφθορομεθυλ)φαινυλ]αμινο}καρβονυλ)αmινο]φαινοξυ}ν-μεθυλπυριδιν-2-καρβοξαμιδιου

Info

Publication number
CY1116126T1
CY1116126T1 CY20151100268T CY151100268T CY1116126T1 CY 1116126 T1 CY1116126 T1 CY 1116126T1 CY 20151100268 T CY20151100268 T CY 20151100268T CY 151100268 T CY151100268 T CY 151100268T CY 1116126 T1 CY1116126 T1 CY 1116126T1
Authority
CY
Cyprus
Prior art keywords
amino
chloro
formula
compound
phenoxy
Prior art date
Application number
CY20151100268T
Other languages
English (en)
Inventor
Michael Lögers
Reinhold Gehring
Oliver Kuhn
Mike Matthäus
Klaus Mohrs
Matthias Müller-Gliemann
Jürgen Stiehl
Mathias Berwe
Jana Lenz
Werner Heilmann
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116126(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of CY1116126T1 publication Critical patent/CY1116126T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Developing Agents For Electrophotography (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μία διαδικασία για την παρασκευή 4-{4-[({[4-χλωρο-3-(τριφθορομεθυλ)-φαινυλ]αμινο}καρβονυλ)αμινο]φαινοξυ}-N-μεθυλ πυριδιν-2-καρβοξαμίδιου και του τοσυλικού άλατος του. Τύπου (I), που περιέχει, σε ένα πρώτο βήμα, την αντίδραση της ένωσης του Τύπου (V) με ισοκυανικό 4-χλωρο-3-τριφθορομεθυλφαινύλιο σε έναν μη χλωριωμένο οργανικό διαλύτη, αδρανή προς τα ισοκυανικά, τοποθετώντας αρχικά την ένωση του Τύπου (V) σε θερμοκρασία από 20°C ως 60°C και προσμιγνύοντας με ισοκυανικό 4-χλωρο-3-τριφθορομεθυλφαινύλιο με τέτοιο τρόπο ώστε η θερμοκρασία αντίδρασης να μην υπερβαίνει τους 70°C για να δώσει την ένωση του τύπου (II) και, σε ένα δεύτερο βήμα, την πρόσμιξη της ένωσης του τύπου (II) με p-τολουολοσουλφονικό οξύ σε έναν πολικό διαλύτη σε θερμοκρασία αντίδρασης από 40°C ως την θερμοκρασία αναρροής του διαλύτη που χρησιμοποιείται.
CY20151100268T 2004-09-29 2015-03-17 Διαδικασια για την παρασκευη 4-{4-[({[4-χλωρο-3-(τριφθορομεθυλ)φαινυλ]αμινο}καρβονυλ)αmινο]φαινοξυ}ν-μεθυλπυριδιν-2-καρβοξαμιδιου CY1116126T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04023131 2004-09-29
EP05794785.5A EP1797037B1 (en) 2004-09-29 2005-09-20 Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyoxy}n-methylpyridine-2-carboxamide

Publications (1)

Publication Number Publication Date
CY1116126T1 true CY1116126T1 (el) 2017-02-08

Family

ID=35457568

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100268T CY1116126T1 (el) 2004-09-29 2015-03-17 Διαδικασια για την παρασκευη 4-{4-[({[4-χλωρο-3-(τριφθορομεθυλ)φαινυλ]αμινο}καρβονυλ)αmινο]φαινοξυ}ν-μεθυλπυριδιν-2-καρβοξαμιδιου

Country Status (35)

Country Link
US (1) US8124782B2 (el)
EP (1) EP1797037B1 (el)
JP (2) JP2008514657A (el)
KR (1) KR101263032B1 (el)
CN (1) CN101052619B (el)
AR (1) AR053973A1 (el)
AU (1) AU2005289099B2 (el)
BR (1) BRPI0515944B1 (el)
CA (1) CA2581835C (el)
CU (1) CU23754B7 (el)
CY (1) CY1116126T1 (el)
DK (1) DK1797037T3 (el)
DO (1) DOP2005000183A (el)
EC (1) ECSP077357A (el)
ES (1) ES2532377T3 (el)
GT (1) GT200500269A (el)
HK (1) HK1113484A1 (el)
HN (1) HN2005000768A (el)
HR (1) HRP20150295T1 (el)
IL (1) IL182046A0 (el)
MA (1) MA28883B1 (el)
MY (1) MY149873A (el)
NO (1) NO339647B1 (el)
NZ (1) NZ554119A (el)
PE (5) PE20091587A1 (el)
PL (1) PL1797037T3 (el)
PT (1) PT1797037E (el)
SG (1) SG155997A1 (el)
SI (1) SI1797037T1 (el)
SV (1) SV2006002243A (el)
TW (1) TWI382973B (el)
UA (1) UA90691C2 (el)
UY (1) UY29143A1 (el)
WO (1) WO2006034796A1 (el)
ZA (1) ZA200702511B (el)

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CN110204483B (zh) * 2014-12-01 2021-06-29 石药集团中奇制药技术（石家庄）有限公司 一种甲苯磺酸索拉非尼新晶型及其制备方法
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Also Published As

Publication number Publication date
MA28883B1 (fr) 2007-09-03
HK1113484A1 (en) 2008-10-03
JP2013067625A (ja) 2013-04-18
UY29143A1 (es) 2006-04-28
CA2581835C (en) 2012-12-18
HRP20150295T1 (hr) 2015-05-22
SI1797037T1 (sl) 2015-06-30
CN101052619A (zh) 2007-10-10
PE20091585A1 (es) 2009-10-31
NO339647B1 (no) 2017-01-16
MY149873A (en) 2013-10-31
PE20091584A1 (es) 2009-10-28
ZA200702511B (en) 2008-07-30
CU20070069A7 (es) 2010-11-27
HN2005000768A (es) 2010-09-17
NO20072173L (no) 2007-06-14
PL1797037T3 (pl) 2015-07-31
CN101052619B (zh) 2012-02-22
KR101263032B1 (ko) 2013-05-09
ES2532377T3 (es) 2015-03-26
WO2006034796A1 (en) 2006-04-06
PE20091587A1 (es) 2009-11-05
AU2005289099B2 (en) 2012-07-19
DK1797037T3 (en) 2015-03-30
GT200500269A (es) 2006-05-11
US8124782B2 (en) 2012-02-28
US20080262236A1 (en) 2008-10-23
TWI382973B (zh) 2013-01-21
CA2581835A1 (en) 2006-04-06
PT1797037E (pt) 2015-03-17
DOP2005000183A (es) 2006-03-31
JP2008514657A (ja) 2008-05-08
EP1797037A1 (en) 2007-06-20
NZ554119A (en) 2010-07-30
ECSP077357A (es) 2007-04-26
EP1797037B1 (en) 2014-12-17
JP5583190B2 (ja) 2014-09-03
PE20060825A1 (es) 2006-10-20
TW200626551A (en) 2006-08-01
UA90691C2 (en) 2010-05-25
AU2005289099A1 (en) 2006-04-06
KR20070058676A (ko) 2007-06-08
BRPI0515944A (pt) 2008-08-12
AR053973A1 (es) 2007-05-30
PE20091586A1 (es) 2009-10-31
BRPI0515944B1 (pt) 2021-11-09
SV2006002243A (es) 2006-10-13
IL182046A0 (en) 2007-07-24
SG155997A1 (en) 2009-10-29
CU23754B7 (es) 2012-01-31

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