PL2528899T3 - Solwat sorafenibu z dimetylosulfotlenkiem - Google Patents
Solwat sorafenibu z dimetylosulfotlenkiemInfo
- Publication number
- PL2528899T3 PL2528899T3 PL11706017T PL11706017T PL2528899T3 PL 2528899 T3 PL2528899 T3 PL 2528899T3 PL 11706017 T PL11706017 T PL 11706017T PL 11706017 T PL11706017 T PL 11706017T PL 2528899 T3 PL2528899 T3 PL 2528899T3
- Authority
- PL
- Poland
- Prior art keywords
- dimethyl sulphoxide
- sulphoxide solvate
- sorafenib dimethyl
- sorafenib
- solvate
- Prior art date
Links
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 title 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 title 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 title 1
- 239000012453 solvate Substances 0.000 title 1
- 229960003787 sorafenib Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN204DE2010 | 2010-01-29 | ||
| PCT/IB2011/050396 WO2011092663A2 (en) | 2010-01-29 | 2011-01-28 | 4-(4-{3-[4-chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-n2-methylpyridine-2-carboxamide dimethyl sulphoxide solvate |
| EP11706017.8A EP2528899B1 (en) | 2010-01-29 | 2011-01-28 | Sorafenib dimethyl sulphoxide solvate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2528899T3 true PL2528899T3 (pl) | 2015-02-27 |
Family
ID=44243630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11706017T PL2528899T3 (pl) | 2010-01-29 | 2011-01-28 | Solwat sorafenibu z dimetylosulfotlenkiem |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8618305B2 (pl) |
| EP (1) | EP2528899B1 (pl) |
| AU (1) | AU2011210326B2 (pl) |
| CA (1) | CA2788146C (pl) |
| PL (1) | PL2528899T3 (pl) |
| WO (1) | WO2011092663A2 (pl) |
| ZA (1) | ZA201206297B (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9156789B2 (en) | 2012-05-21 | 2015-10-13 | Hetero Research Foundation | Process for sorafenib tosylate polymorph III |
| WO2014138905A1 (en) * | 2013-03-14 | 2014-09-18 | Apotex Technologies Inc. | Forms of sorafenib tosylate and processes for the preparation thereof |
| CN104710354A (zh) * | 2013-12-13 | 2015-06-17 | 江苏豪森药业股份有限公司 | 高纯度索拉非尼的制备方法 |
| CN104761492A (zh) * | 2014-01-03 | 2015-07-08 | 正大天晴药业集团股份有限公司 | 对甲苯磺酸索拉非尼的晶型及其制备方法 |
| CN105181844A (zh) * | 2015-09-11 | 2015-12-23 | 江苏嘉逸医药有限公司 | 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法 |
| CN106841487A (zh) * | 2015-12-04 | 2017-06-13 | 天津药物研究院有限公司 | 一种索拉非尼中杂质的检测方法及其应用 |
| CN105651877A (zh) * | 2015-12-30 | 2016-06-08 | 神威药业集团有限公司 | 一种索拉非尼及其有关物质的检测方法 |
| CN109796400B (zh) * | 2017-11-16 | 2022-07-29 | 四川科伦药物研究院有限公司 | 一种甲苯磺酸索拉菲尼晶型及其制备方法 |
| CN108426964A (zh) * | 2018-06-01 | 2018-08-21 | 青岛农业大学 | 一种液质联用检测水中苯乙酸含量的方法 |
| CN109187831B (zh) * | 2018-09-29 | 2021-08-03 | 云南中烟工业有限责任公司 | 采用gc-ms同时快速测定酒精中9种醇类化合物含量的方法 |
| CN109613135A (zh) * | 2018-12-24 | 2019-04-12 | 苏州市疾病预防控制中心 | 一种血中n-甲基氨甲酰加合物的快速检测方法 |
| CN110243969B (zh) * | 2019-06-28 | 2021-09-03 | 成都中医药大学 | 一种同时测定虎掌南星中7种有机酸的hplc方法 |
| CN110243970B (zh) * | 2019-06-28 | 2021-09-03 | 成都中医药大学 | 一种同时测定半夏中7种有机酸的hplc方法 |
| JP7748786B2 (ja) * | 2020-12-31 | 2025-10-03 | 亜琴 ▲とん▼ | がんを治療するための医薬組成物、その製造方法及び使用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1626714B1 (en) | 2003-05-20 | 2007-07-04 | Bayer Pharmaceuticals Corporation | Diaryl ureas for diseases mediated by pdgfr |
| BRPI0515946A (pt) | 2004-09-29 | 2008-08-12 | Bayer Healthcare Ag | sal de tosilato, sua preparação e uso, bem como composição farmacêutica compreendendo o mesmo |
| KR101263032B1 (ko) | 2004-09-29 | 2013-05-09 | 바이엘 파마 악티엔게젤샤프트 | 4-｛4-［（｛［4-클로로-3-（트리플루오로메틸）페닐］아미노｝카르보닐）아미노］페녹시｝-ｎ-메틸피리딘-2-카르복사미드의 제조 방법 |
| CA2601955C (en) | 2005-03-07 | 2012-07-10 | Bayer Healthcare Ag | Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer |
| JP5178738B2 (ja) * | 2006-12-20 | 2013-04-10 | メルク・シャープ・アンド・ドーム・コーポレーション | 新規なｊｎｋ阻害剤 |
| JP5438680B2 (ja) | 2007-09-10 | 2014-03-12 | シプラ・リミテッド | Ｒａｆキナーゼ阻害剤の製造方法及び該方法に使用する中間体 |
| WO2009054004A2 (en) * | 2007-10-22 | 2009-04-30 | Natco Pharma Limited | Process for the preparation of sorafenib |
| EP2231612A1 (en) | 2008-01-17 | 2010-09-29 | Sicor, Inc. | Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof |
| WO2009106825A1 (en) * | 2008-02-27 | 2009-09-03 | Cipla Limited | Polymorphs of sorafenib and salts thereof |
| US20090253913A1 (en) * | 2008-03-06 | 2009-10-08 | Pierluigi Rossetto | Process for the preparation of sorafenib and salts thereof |
-
2011
- 2011-01-28 US US13/575,057 patent/US8618305B2/en not_active Expired - Fee Related
- 2011-01-28 AU AU2011210326A patent/AU2011210326B2/en not_active Ceased
- 2011-01-28 PL PL11706017T patent/PL2528899T3/pl unknown
- 2011-01-28 CA CA2788146A patent/CA2788146C/en not_active Expired - Fee Related
- 2011-01-28 EP EP11706017.8A patent/EP2528899B1/en not_active Not-in-force
- 2011-01-28 WO PCT/IB2011/050396 patent/WO2011092663A2/en not_active Ceased
-
2012
- 2012-08-21 ZA ZA2012/06297A patent/ZA201206297B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011210326A1 (en) | 2012-08-16 |
| ZA201206297B (en) | 2013-06-26 |
| CA2788146C (en) | 2014-11-25 |
| EP2528899A2 (en) | 2012-12-05 |
| US20130210865A1 (en) | 2013-08-15 |
| EP2528899B1 (en) | 2014-10-15 |
| CA2788146A1 (en) | 2011-08-04 |
| WO2011092663A3 (en) | 2011-12-29 |
| US8618305B2 (en) | 2013-12-31 |
| WO2011092663A2 (en) | 2011-08-04 |
| AU2011210326B2 (en) | 2014-10-09 |
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