PL2528899T3 - Solwat sorafenibu z dimetylosulfotlenkiem - Google Patents
Solwat sorafenibu z dimetylosulfotlenkiemInfo
- Publication number
- PL2528899T3 PL2528899T3 PL11706017T PL11706017T PL2528899T3 PL 2528899 T3 PL2528899 T3 PL 2528899T3 PL 11706017 T PL11706017 T PL 11706017T PL 11706017 T PL11706017 T PL 11706017T PL 2528899 T3 PL2528899 T3 PL 2528899T3
- Authority
- PL
- Poland
- Prior art keywords
- dimethyl sulphoxide
- sulphoxide solvate
- sorafenib dimethyl
- sorafenib
- solvate
- Prior art date
Links
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 title 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 title 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 title 1
- 239000012453 solvate Substances 0.000 title 1
- 229960003787 sorafenib Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN204DE2010 | 2010-01-29 | ||
| EP11706017.8A EP2528899B1 (en) | 2010-01-29 | 2011-01-28 | Sorafenib dimethyl sulphoxide solvate |
| PCT/IB2011/050396 WO2011092663A2 (en) | 2010-01-29 | 2011-01-28 | 4-(4-{3-[4-chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-n2-methylpyridine-2-carboxamide dimethyl sulphoxide solvate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2528899T3 true PL2528899T3 (pl) | 2015-02-27 |
Family
ID=44243630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11706017T PL2528899T3 (pl) | 2010-01-29 | 2011-01-28 | Solwat sorafenibu z dimetylosulfotlenkiem |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8618305B2 (pl) |
| EP (1) | EP2528899B1 (pl) |
| AU (1) | AU2011210326B2 (pl) |
| CA (1) | CA2788146C (pl) |
| PL (1) | PL2528899T3 (pl) |
| WO (1) | WO2011092663A2 (pl) |
| ZA (1) | ZA201206297B (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013175506A2 (en) * | 2012-05-21 | 2013-11-28 | Hetero Research Foundation | Process for sorafenib tosylate polymorph iii |
| WO2014138905A1 (en) * | 2013-03-14 | 2014-09-18 | Apotex Technologies Inc. | Forms of sorafenib tosylate and processes for the preparation thereof |
| CN104710354A (zh) * | 2013-12-13 | 2015-06-17 | 江苏豪森药业股份有限公司 | 高纯度索拉非尼的制备方法 |
| CN104761492A (zh) * | 2014-01-03 | 2015-07-08 | 正大天晴药业集团股份有限公司 | 对甲苯磺酸索拉非尼的晶型及其制备方法 |
| CN105181844A (zh) * | 2015-09-11 | 2015-12-23 | 江苏嘉逸医药有限公司 | 一种高效液相色谱法测定甲苯磺酸索拉非尼含量和有关物质的方法 |
| CN106841487A (zh) * | 2015-12-04 | 2017-06-13 | 天津药物研究院有限公司 | 一种索拉非尼中杂质的检测方法及其应用 |
| CN105651877A (zh) * | 2015-12-30 | 2016-06-08 | 神威药业集团有限公司 | 一种索拉非尼及其有关物质的检测方法 |
| CN109796400B (zh) * | 2017-11-16 | 2022-07-29 | 四川科伦药物研究院有限公司 | 一种甲苯磺酸索拉菲尼晶型及其制备方法 |
| CN108426964A (zh) * | 2018-06-01 | 2018-08-21 | 青岛农业大学 | 一种液质联用检测水中苯乙酸含量的方法 |
| CN109187831B (zh) * | 2018-09-29 | 2021-08-03 | 云南中烟工业有限责任公司 | 采用gc-ms同时快速测定酒精中9种醇类化合物含量的方法 |
| CN109613135A (zh) * | 2018-12-24 | 2019-04-12 | 苏州市疾病预防控制中心 | 一种血中n-甲基氨甲酰加合物的快速检测方法 |
| CN110243970B (zh) * | 2019-06-28 | 2021-09-03 | 成都中医药大学 | 一种同时测定半夏中7种有机酸的hplc方法 |
| CN110243969B (zh) * | 2019-06-28 | 2021-09-03 | 成都中医药大学 | 一种同时测定虎掌南星中7种有机酸的hplc方法 |
| CN118948825A (zh) * | 2020-12-31 | 2024-11-15 | 沈阳糖化药物研究有限公司 | 一种用于治疗癌症的药物组合物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| NZ554119A (en) | 2004-09-29 | 2010-07-30 | Bayer Schering Pharma Ag | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide |
| KR101381454B1 (ko) | 2004-09-29 | 2014-04-04 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 열역학적으로 안정한 형태의 ｂａｙ 43-9006 토실레이트 |
| KR101335932B1 (ko) | 2005-03-07 | 2013-12-04 | 바이엘 헬스케어 엘엘씨 | 암의 치료를 위한 오메가-카르복시아릴 치환된 디페닐우레아를 포함하는 제약 조성물 |
| CN101611007A (zh) * | 2006-12-20 | 2009-12-23 | 先灵公司 | 新颖的jnk抑制剂 |
| CA2698795C (en) | 2007-09-10 | 2016-04-19 | Cipla Limited | Process for the preparation of a raf kinase inhibitor and intermediates for use in the process |
| WO2009054004A2 (en) | 2007-10-22 | 2009-04-30 | Natco Pharma Limited | Process for the preparation of sorafenib |
| WO2009092070A1 (en) * | 2008-01-17 | 2009-07-23 | Sicor Inc. | Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof |
| WO2009106825A1 (en) | 2008-02-27 | 2009-09-03 | Cipla Limited | Polymorphs of sorafenib and salts thereof |
| EP2142507A1 (en) | 2008-03-06 | 2010-01-13 | Sicor, Inc. | Process for the preparation of sorafenib and salts thereof |
-
2011
- 2011-01-28 PL PL11706017T patent/PL2528899T3/pl unknown
- 2011-01-28 AU AU2011210326A patent/AU2011210326B2/en not_active Ceased
- 2011-01-28 CA CA2788146A patent/CA2788146C/en not_active Expired - Fee Related
- 2011-01-28 US US13/575,057 patent/US8618305B2/en not_active Expired - Fee Related
- 2011-01-28 EP EP11706017.8A patent/EP2528899B1/en not_active Not-in-force
- 2011-01-28 WO PCT/IB2011/050396 patent/WO2011092663A2/en not_active Ceased
-
2012
- 2012-08-21 ZA ZA2012/06297A patent/ZA201206297B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011092663A2 (en) | 2011-08-04 |
| CA2788146A1 (en) | 2011-08-04 |
| AU2011210326B2 (en) | 2014-10-09 |
| WO2011092663A3 (en) | 2011-12-29 |
| EP2528899B1 (en) | 2014-10-15 |
| CA2788146C (en) | 2014-11-25 |
| US20130210865A1 (en) | 2013-08-15 |
| ZA201206297B (en) | 2013-06-26 |
| EP2528899A2 (en) | 2012-12-05 |
| US8618305B2 (en) | 2013-12-31 |
| AU2011210326A1 (en) | 2012-08-16 |
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