PL2536710T3 - Pochodne piperydyny - Google Patents
Pochodne piperydynyInfo
- Publication number
- PL2536710T3 PL2536710T3 PL11702848T PL11702848T PL2536710T3 PL 2536710 T3 PL2536710 T3 PL 2536710T3 PL 11702848 T PL11702848 T PL 11702848T PL 11702848 T PL11702848 T PL 11702848T PL 2536710 T3 PL2536710 T3 PL 2536710T3
- Authority
- PL
- Poland
- Prior art keywords
- piperidine derivatives
- piperidine
- derivatives
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10153843 | 2010-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2536710T3 true PL2536710T3 (pl) | 2017-01-31 |
Family
ID=43757885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11702848T PL2536710T3 (pl) | 2010-02-17 | 2011-02-14 | Pochodne piperydyny |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8486967B2 (pl) |
| EP (1) | EP2536710B1 (pl) |
| JP (1) | JP5559362B2 (pl) |
| KR (1) | KR101472648B1 (pl) |
| CN (1) | CN103025724B (pl) |
| AR (1) | AR080177A1 (pl) |
| BR (1) | BR112012020607A2 (pl) |
| CA (1) | CA2789058A1 (pl) |
| CY (1) | CY1117976T1 (pl) |
| DK (1) | DK2536710T3 (pl) |
| ES (1) | ES2594491T3 (pl) |
| HR (1) | HRP20161232T1 (pl) |
| HU (1) | HUE028178T2 (pl) |
| LT (1) | LT2536710T (pl) |
| MX (1) | MX2012009545A (pl) |
| PL (1) | PL2536710T3 (pl) |
| PT (1) | PT2536710T (pl) |
| RS (1) | RS55243B1 (pl) |
| RU (1) | RU2554353C2 (pl) |
| SI (1) | SI2536710T1 (pl) |
| TW (1) | TW201130818A (pl) |
| WO (1) | WO2011101304A2 (pl) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8703763B2 (en) | 2011-03-02 | 2014-04-22 | Hoffmann-La Roche Inc. | Bridged piperidine derivatives |
| EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
| JP6479476B2 (ja) * | 2012-02-21 | 2019-03-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ＳｙｋチロシンキナーゼインヒビターおよびＧＣＮ２セリンキナーゼインヒビターとしての８−置換２−アミノー［１，２，４］トリアゾロ［１，５−Ａ］ピラジン類 |
| JP6472803B2 (ja) * | 2013-09-05 | 2019-02-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾロピリジン化合物、その組成物及び使用方法 |
| WO2015066696A1 (en) * | 2013-11-04 | 2015-05-07 | Forum Pharmaceuticals Inc. | Fused morphlinopyrimidines and methods of use thereof |
| EP3085700B1 (en) * | 2013-12-20 | 2018-10-31 | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China | Novel piperidine carboxamide compound, preparation method, and usage thereof |
| WO2015138689A1 (en) * | 2014-03-13 | 2015-09-17 | Forum Pharmaceuticals Inc. | Fused morpholinopyrimidines and methods of use thereof |
| CN103896875B (zh) * | 2014-04-14 | 2015-10-14 | 仪征市海帆化工有限公司 | 一种5-乙氧基-3-三氯甲基-1,2,4-噻二唑的合成方法 |
| WO2017042114A1 (en) * | 2015-09-09 | 2017-03-16 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| EP3386978B1 (en) * | 2015-12-10 | 2021-01-27 | H. Hoffnabb-La Roche Ag | Bridged piperidine derivatives |
| CN109311878B (zh) * | 2016-06-27 | 2022-05-24 | 豪夫迈·罗氏有限公司 | 作为γ-分泌酶调节剂的三唑并吡啶类化合物 |
| AR109829A1 (es) | 2016-09-29 | 2019-01-30 | Hoffmann La Roche | Derivados de piperidina puenteados |
| EP3523304B1 (en) * | 2016-10-04 | 2021-01-27 | H. Hoffnabb-La Roche Ag | Bicyclic heteroaryl derivatives |
| EP3535266B1 (en) * | 2016-11-01 | 2021-12-29 | F. Hoffmann-La Roche AG | Bicyclic heteroaryl derivatives |
| US11370802B2 (en) * | 2018-01-22 | 2022-06-28 | Hoffmann-La Roche, Inc. | Triazolo-azepine derivatives |
| MX2021002087A (es) * | 2018-09-03 | 2021-04-28 | Hoffmann La Roche | Derivados de heteroarilo biciclicos. |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| AU2019395774B2 (en) | 2018-12-13 | 2024-12-12 | F. Hoffmann-La Roche Ag | 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of Alzheimer's disease |
| JP7644009B2 (ja) | 2018-12-21 | 2025-03-11 | オゲダ エス．エー． | ３－メチル－１，２，４－チアジアゾール－５－カルボヒドラジドまたはそのメチル－ｄ３重水素化形態の合成 |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| WO2021030537A1 (en) | 2019-08-14 | 2021-02-18 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| CR20220170A (es) | 2019-10-11 | 2022-10-10 | Incyte Corp | Aminas bicíclicas como inhibidoras de la cdk2 |
| TW202204350A (zh) | 2020-05-06 | 2022-02-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| WO2023009708A1 (en) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Heteroaryloxy triazolo- and imidazo-azines as jak2 inhibitors |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| WO2026146201A1 (en) * | 2025-01-03 | 2026-07-09 | AlzeCure Pharma AB | New compounds and uses |
| CN122079868A (zh) * | 2026-04-22 | 2026-05-26 | 沈阳药科大学 | N-烷氧羰基-4-氨基-4-烷基哌啶的合成方法 |
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-
2011
- 2011-02-09 US US13/023,563 patent/US8486967B2/en not_active Expired - Fee Related
- 2011-02-14 PL PL11702848T patent/PL2536710T3/pl unknown
- 2011-02-14 PT PT117028480T patent/PT2536710T/pt unknown
- 2011-02-14 BR BR112012020607A patent/BR112012020607A2/pt active Search and Examination
- 2011-02-14 KR KR1020127024041A patent/KR101472648B1/ko not_active Expired - Fee Related
- 2011-02-14 ES ES11702848.0T patent/ES2594491T3/es active Active
- 2011-02-14 TW TW100104827A patent/TW201130818A/zh unknown
- 2011-02-14 SI SI201130971A patent/SI2536710T1/sl unknown
- 2011-02-14 JP JP2012553275A patent/JP5559362B2/ja not_active Expired - Fee Related
- 2011-02-14 CA CA2789058A patent/CA2789058A1/en not_active Abandoned
- 2011-02-14 EP EP11702848.0A patent/EP2536710B1/en not_active Not-in-force
- 2011-02-14 RS RS20160847A patent/RS55243B1/sr unknown
- 2011-02-14 DK DK11702848.0T patent/DK2536710T3/en active
- 2011-02-14 RU RU2012137956/04A patent/RU2554353C2/ru not_active IP Right Cessation
- 2011-02-14 WO PCT/EP2011/052101 patent/WO2011101304A2/en not_active Ceased
- 2011-02-14 MX MX2012009545A patent/MX2012009545A/es active IP Right Grant
- 2011-02-14 CN CN201180010086.0A patent/CN103025724B/zh not_active Expired - Fee Related
- 2011-02-14 LT LTEP11702848.0T patent/LT2536710T/lt unknown
- 2011-02-14 HU HUE11702848A patent/HUE028178T2/en unknown
- 2011-02-14 HR HRP20161232TT patent/HRP20161232T1/hr unknown
- 2011-02-15 AR ARP110100450A patent/AR080177A1/es unknown
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2016
- 2016-09-07 CY CY20161100890T patent/CY1117976T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011101304A2 (en) | 2011-08-25 |
| JP2013519701A (ja) | 2013-05-30 |
| US20110201605A1 (en) | 2011-08-18 |
| EP2536710A2 (en) | 2012-12-26 |
| RU2012137956A (ru) | 2014-03-27 |
| JP5559362B2 (ja) | 2014-07-23 |
| ES2594491T3 (es) | 2016-12-20 |
| EP2536710B1 (en) | 2016-07-13 |
| MX2012009545A (es) | 2012-09-12 |
| HUE028178T2 (en) | 2016-12-28 |
| LT2536710T (lt) | 2016-09-26 |
| TW201130818A (en) | 2011-09-16 |
| RS55243B1 (sr) | 2017-02-28 |
| US8486967B2 (en) | 2013-07-16 |
| KR101472648B1 (ko) | 2014-12-15 |
| RU2554353C2 (ru) | 2015-06-27 |
| HK1179958A1 (en) | 2013-10-11 |
| KR20120124489A (ko) | 2012-11-13 |
| PT2536710T (pt) | 2016-09-27 |
| CN103025724A (zh) | 2013-04-03 |
| AR080177A1 (es) | 2012-03-21 |
| DK2536710T3 (en) | 2016-08-22 |
| BR112012020607A2 (pt) | 2016-07-19 |
| CA2789058A1 (en) | 2011-08-25 |
| CN103025724B (zh) | 2015-02-11 |
| WO2011101304A3 (en) | 2011-10-20 |
| SI2536710T1 (sl) | 2016-11-30 |
| CY1117976T1 (el) | 2017-05-17 |
| HRP20161232T1 (hr) | 2016-11-04 |
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