CN1219530A - 一种精制长链二元酸的方法 - Google Patents
一种精制长链二元酸的方法 Download PDFInfo
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- CN1219530A CN1219530A CN97121846A CN97121846A CN1219530A CN 1219530 A CN1219530 A CN 1219530A CN 97121846 A CN97121846 A CN 97121846A CN 97121846 A CN97121846 A CN 97121846A CN 1219530 A CN1219530 A CN 1219530A
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- acid
- salting
- dicarboxylate
- water
- filtration
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- 239000002253 acid Substances 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000007670 refining Methods 0.000 title claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 238000005185 salting out Methods 0.000 claims abstract description 17
- 239000000049 pigment Substances 0.000 claims abstract description 15
- 238000002425 crystallisation Methods 0.000 claims abstract description 14
- 230000008025 crystallization Effects 0.000 claims abstract description 14
- 239000012535 impurity Substances 0.000 claims abstract description 14
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 7
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 7
- 239000003513 alkali Substances 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 239000000047 product Substances 0.000 claims description 28
- 150000007520 diprotic acids Chemical class 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 238000000855 fermentation Methods 0.000 abstract description 5
- 230000004151 fermentation Effects 0.000 abstract description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 10
- -1 diprotic acid sodium salt Chemical class 0.000 description 10
- 239000012065 filter cake Substances 0.000 description 8
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000012452 mother liquor Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 150000001335 aliphatic alkanes Chemical class 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- IIYFAKIEWZDVMP-UHFFFAOYSA-N linear paraffin C13 Natural products CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 3
- 239000002932 luster Substances 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- BGHCVCJVXZWKCC-UHFFFAOYSA-N tetradecane Chemical compound CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000222178 Candida tropicalis Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 229920006351 engineering plastic Polymers 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
DC13纯度 | DC13中残留nC13 | 色泽 | 产品收率 |
99.1m% | 未检出 | 白色 | 90.2m% |
产品纯度 | 产品含nC13+nC14 | 产品收率 | 外观色泽 |
97.2m% | 未检出 | 91.3m% | 白色 |
DC13纯度 | 产品含nC13 | 产品收率 | 色泽 |
96.1m% | 未检出 | 91.2m% | 白色 |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN971218463A CN1064951C (zh) | 1997-12-08 | 1997-12-08 | 一种精制长链二元酸的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN971218463A CN1064951C (zh) | 1997-12-08 | 1997-12-08 | 一种精制长链二元酸的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1219530A true CN1219530A (zh) | 1999-06-16 |
CN1064951C CN1064951C (zh) | 2001-04-25 |
Family
ID=5176493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN971218463A Expired - Lifetime CN1064951C (zh) | 1997-12-08 | 1997-12-08 | 一种精制长链二元酸的方法 |
Country Status (1)
Country | Link |
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CN (1) | CN1064951C (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102190572A (zh) * | 2010-02-05 | 2011-09-21 | 上海凯赛生物技术研发中心有限公司 | 长链二元酸的分离纯化方法 |
DE102012105128A1 (de) | 2011-09-30 | 2013-04-04 | Institute Of Microbiology Chinese Academy Of Sciences | Verfahren zur Darstellung langkettiger Dicarbonsäuren und deren Herstellung |
CN103497100A (zh) * | 2013-09-23 | 2014-01-08 | 中国石油化工股份有限公司 | 长链二元酸水相双阶段提纯方法 |
US8729298B2 (en) | 2011-03-28 | 2014-05-20 | Cathay Industrial Biotech Ltd. | Method for separation and purification of long-chain diacids |
CN104844440A (zh) * | 2014-02-17 | 2015-08-19 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的精制方法 |
CN104844441A (zh) * | 2014-02-17 | 2015-08-19 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的提纯方法 |
CN106699802A (zh) * | 2016-12-21 | 2017-05-24 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀钙中间体的纯化方法 |
CN108017535A (zh) * | 2016-11-01 | 2018-05-11 | 中国石油化工股份有限公司 | 一种从发酵液中提取长链二元酸的方法 |
CN114181073A (zh) * | 2017-12-28 | 2022-03-15 | 凯赛(金乡)生物材料有限公司 | 一种长链二元酸氧化脱色工艺 |
CN114524722A (zh) * | 2020-10-31 | 2022-05-24 | 中国石油化工股份有限公司 | 一种提取长链二元酸的方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101698859B (zh) * | 2009-09-11 | 2012-07-18 | 淄博广通化工有限责任公司 | 正十六烷二元酸生产方法 |
CN102795984B (zh) * | 2012-08-28 | 2015-03-25 | 淄博广通化工有限责任公司 | 长碳链混合二元酸的生产方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5626193A (en) * | 1979-08-09 | 1981-03-13 | Nippon Mining Co Ltd | Removal of microbial cell from fermentation broth of long-chain dicarboxylic acid |
JPS5626194A (en) * | 1979-08-09 | 1981-03-13 | Nippon Mining Co Ltd | Purification of long-chain dicarboxylic acid produced by fermentation |
CN1029842C (zh) * | 1991-09-11 | 1995-09-27 | 中国石油化工总公司抚顺石油化工研究院 | 一种精制长链二元酸的方法 |
CN1147106A (zh) * | 1995-09-07 | 1997-04-09 | 秦之勇 | 计算机重码汉字的字母键选字输入法 |
-
1997
- 1997-12-08 CN CN971218463A patent/CN1064951C/zh not_active Expired - Lifetime
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102190572A (zh) * | 2010-02-05 | 2011-09-21 | 上海凯赛生物技术研发中心有限公司 | 长链二元酸的分离纯化方法 |
US8729298B2 (en) | 2011-03-28 | 2014-05-20 | Cathay Industrial Biotech Ltd. | Method for separation and purification of long-chain diacids |
DE102012105128A1 (de) | 2011-09-30 | 2013-04-04 | Institute Of Microbiology Chinese Academy Of Sciences | Verfahren zur Darstellung langkettiger Dicarbonsäuren und deren Herstellung |
DE102012105128B4 (de) | 2011-09-30 | 2023-05-17 | Institute Of Microbiology, Chinese Academy Of Sciences | Verfahren zur Darstellung langkettiger Dicarbonsäuren |
CN103497100A (zh) * | 2013-09-23 | 2014-01-08 | 中国石油化工股份有限公司 | 长链二元酸水相双阶段提纯方法 |
CN110256238A (zh) * | 2014-02-17 | 2019-09-20 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的精制方法 |
CN104844440A (zh) * | 2014-02-17 | 2015-08-19 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的精制方法 |
CN104844441A (zh) * | 2014-02-17 | 2015-08-19 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的提纯方法 |
CN110256238B (zh) * | 2014-02-17 | 2021-09-28 | 上海凯赛生物技术股份有限公司 | 一种长链混合二元酸的精制方法 |
CN104844440B (zh) * | 2014-02-17 | 2019-05-31 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的精制方法 |
CN104844441B (zh) * | 2014-02-17 | 2019-05-31 | 上海凯赛生物技术研发中心有限公司 | 一种长链混合二元酸的提纯方法 |
CN108017535B (zh) * | 2016-11-01 | 2020-09-11 | 中国石油化工股份有限公司 | 一种从发酵液中提取长链二元酸的方法 |
CN108017535A (zh) * | 2016-11-01 | 2018-05-11 | 中国石油化工股份有限公司 | 一种从发酵液中提取长链二元酸的方法 |
CN106699802B (zh) * | 2016-12-21 | 2019-01-25 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀钙中间体的纯化方法 |
CN106699802A (zh) * | 2016-12-21 | 2017-05-24 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀钙中间体的纯化方法 |
CN114181073A (zh) * | 2017-12-28 | 2022-03-15 | 凯赛(金乡)生物材料有限公司 | 一种长链二元酸氧化脱色工艺 |
CN114524722A (zh) * | 2020-10-31 | 2022-05-24 | 中国石油化工股份有限公司 | 一种提取长链二元酸的方法 |
Also Published As
Publication number | Publication date |
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CN1064951C (zh) | 2001-04-25 |
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GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: CHINA PETROLEUM AND CHEMICAL CORPORATION FUSHUN P Free format text: FORMER OWNER: CHINA PETROLEUM + CHEMICAL CORPORATION, FUSHUN PETROL-CHEMICAL INSTITUTE Effective date: 20071207 |
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Owner name: CHINA PETROLEUM & CHEMICAL CORPORATION, FUSHUN PET Free format text: FORMER NAME OR ADDRESS: FUSHUN PETROCHEMICAL INSTITUTE., CHINA PETROCHEMICAL CORP. |
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CP01 | Change in the name or title of a patent holder |
Address after: The eastern section of Dandong road Fushun City Wanghua District of Liaoning Province, No. 31 Patentee after: Fushun Petrochemical Inst., China Petrochemical Corp. Address before: The eastern section of Dandong road Fushun City Wanghua District of Liaoning Province, No. 31 Patentee before: SINOPEC DALIAN(FUSHUN)RESEARCH INSTTUTE OF PETROLEUM AND PETROCHEMICALS |
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TR01 | Transfer of patent right |
Effective date of registration: 20071207 Address after: The eastern section of Dandong road Fushun City Wanghua District of Liaoning Province, No. 31 Patentee after: FUSHUN RESEARCH INSTITUTE OF PETROLEUM AND PETROCHEMICALS, SINOPEC Corp. Address before: The eastern section of Dandong road Fushun City Wanghua District of Liaoning Province, No. 31 Patentee before: Fushun Petrochemical Inst., China Petrochemical Corp. |
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CX01 | Expiry of patent term |
Granted publication date: 20010425 |
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CX01 | Expiry of patent term |