CN1216046A - 3-[(1,2,3,4-四氢异喹啉-2-基)甲基]-8-氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用 - Google Patents

3-[(1,2,3,4-四氢异喹啉-2-基)甲基]-8-氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用 Download PDF

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Publication number
CN1216046A
CN1216046A CN97193750A CN97193750A CN1216046A CN 1216046 A CN1216046 A CN 1216046A CN 97193750 A CN97193750 A CN 97193750A CN 97193750 A CN97193750 A CN 97193750A CN 1216046 A CN1216046 A CN 1216046A
Authority
CN
China
Prior art keywords
compound
och
general formula
azabicyclo
octane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97193750A
Other languages
English (en)
Chinese (zh)
Inventor
M·瑟维林
B·马拉鲍特
P·乔治
J·P·梅尔莱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYNTHETIC LABORATORY CORP
Synthelabo SA
Original Assignee
SYNTHETIC LABORATORY CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SYNTHETIC LABORATORY CORP filed Critical SYNTHETIC LABORATORY CORP
Publication of CN1216046A publication Critical patent/CN1216046A/zh
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN97193750A 1996-04-12 1997-04-10 3-[(1,2,3,4-四氢异喹啉-2-基)甲基]-8-氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用 Pending CN1216046A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/04565 1996-04-12
FR9604565A FR2747386B1 (fr) 1996-04-12 1996-04-12 Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CN1216046A true CN1216046A (zh) 1999-05-05

Family

ID=9491132

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193750A Pending CN1216046A (zh) 1996-04-12 1997-04-10 3-[(1,2,3,4-四氢异喹啉-2-基)甲基]-8-氮杂双环[3.2.1]辛烷衍生物,其制备方法以及在疾病治疗中的应用

Country Status (22)

Country Link
EP (1) EP0892800A1 (enrdf_load_stackoverflow)
JP (1) JP2000512620A (enrdf_load_stackoverflow)
KR (1) KR20000005392A (enrdf_load_stackoverflow)
CN (1) CN1216046A (enrdf_load_stackoverflow)
AR (1) AR008587A1 (enrdf_load_stackoverflow)
AU (1) AU2640997A (enrdf_load_stackoverflow)
BG (1) BG102779A (enrdf_load_stackoverflow)
BR (1) BR9708654A (enrdf_load_stackoverflow)
CA (1) CA2251335A1 (enrdf_load_stackoverflow)
CO (1) CO4900067A1 (enrdf_load_stackoverflow)
CZ (1) CZ326898A3 (enrdf_load_stackoverflow)
EE (1) EE9800396A (enrdf_load_stackoverflow)
FR (1) FR2747386B1 (enrdf_load_stackoverflow)
IL (1) IL126473A0 (enrdf_load_stackoverflow)
NO (1) NO984736L (enrdf_load_stackoverflow)
NZ (1) NZ332257A (enrdf_load_stackoverflow)
PL (1) PL329243A1 (enrdf_load_stackoverflow)
SK (1) SK141598A3 (enrdf_load_stackoverflow)
TR (1) TR199801839T2 (enrdf_load_stackoverflow)
TW (1) TW407158B (enrdf_load_stackoverflow)
WO (1) WO1997038998A1 (enrdf_load_stackoverflow)
ZA (1) ZA973124B (enrdf_load_stackoverflow)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2303851A1 (en) * 2008-06-27 2011-04-06 H. Lundbeck A/S Novel phenolic and catecholic amines and prodrugs thereof
WO2018021447A1 (ja) 2016-07-28 2018-02-01 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物
JPWO2019146739A1 (ja) 2018-01-26 2021-01-07 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する縮環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
FR2661178B1 (fr) * 1990-04-24 1993-03-12 Synthelabo Derives de [(tetrahydro-1,2,3,4 isoquinoleinyl-2)methyl]-4 piperidinecarboxylates-1 d'alkyle, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
JP2000512620A (ja) 2000-09-26
TW407158B (en) 2000-10-01
CA2251335A1 (en) 1997-10-23
AU2640997A (en) 1997-11-07
EE9800396A (et) 1999-06-15
BG102779A (en) 1999-09-30
EP0892800A1 (fr) 1999-01-27
AR008587A1 (es) 2000-02-09
NZ332257A (en) 1999-03-29
BR9708654A (pt) 1999-08-03
PL329243A1 (en) 1999-03-15
ZA973124B (en) 1997-11-05
WO1997038998A1 (fr) 1997-10-23
NO984736D0 (no) 1998-10-09
NO984736L (no) 1998-11-23
TR199801839T2 (enrdf_load_stackoverflow) 1998-12-21
CO4900067A1 (es) 2000-03-27
KR20000005392A (ko) 2000-01-25
FR2747386A1 (fr) 1997-10-17
IL126473A0 (en) 1999-08-17
SK141598A3 (en) 1999-03-12
FR2747386B1 (fr) 1998-05-15
CZ326898A3 (cs) 1999-01-13

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